TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium

Journal of Virology

Volumn 87, Issue 11, 2013, Pages 6150-6160

  Bertram, Stephanie ^a,b   Dijkman, Ronald ^c   Habjan, Matthias ^c,e   Heurich, Adeline ^b   Gierer, Stefanie ^b   Glowacka, Ilona ^a   Welsch, Kathrin ^b   Winkler, Michael ^b   Schneider, Heike ^a   Hofmann Winkler, Heike ^b   Volker Thiel, ^c,d   Pöhlmann, Stefan ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b GERMAN PRIMATE CENTER   (Germany)

^c Institute of Immunobiology   (Switzerland)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN; CATHEPSIN L; MICROSOMAL AMINOPEPTIDASE; PROTEIN HAT; PROTEIN TMPRSS2; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CORONAVIRUS; CORONAVIRUS 229E; CORONAVIRUS INFECTION; EPITHELIUM CELL; HOST CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFECTION SENSITIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; VIRUS ACTIVATION; VIRUS ENTRY;

CATHEPSINS; CELL LINE; CORONAVIRUS 229E, HUMAN; CORONAVIRUS INFECTIONS; GENE EXPRESSION; HISTONE ACETYLTRANSFERASES; HUMANS; RESPIRATORY MUCOSA; SERINE ENDOPEPTIDASES; VIRUS INTERNALIZATION;

EID: 84878210363     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.03372-12     Document Type: Article

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