Proteolytic activation of the spike protein at a novel RRRR/S motif is implicated in furin-dependent entry, syncytium formation, and infectivity of coronavirus infectious bronchitis virus in cultured cells

Journal of Virology

Volumn 83, Issue 17, 2009, Pages 8744-8758

  Yamada, Yoshiyuki ^a   Ding, Xiang Liu ^a,b  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

FURIN; SERINE PROTEINASE; VIRUS PROTEIN; MEMBRANE PROTEIN; SPIKE GLYCOPROTEIN, CORONAVIRUS; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; AVIAN INFECTIOUS BRONCHITIS VIRUS; MUTATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; SYNCYTIUM; VERO CELL; VIRUS ENTRY; VIRUS INFECTION; AMINO ACID SUBSTITUTION; ANIMAL; CELL FUSION; CERCOPITHECUS; GIANT CELL; METABOLISM; PHYSIOLOGY; PROTEIN MOTIF; VIROLOGY;

AVIAN INFECTIOUS BRONCHITIS VIRUS; CORONAVIRUS;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; CELL FUSION; CERCOPITHECUS AETHIOPS; FURIN; GIANT CELLS; INFECTIOUS BRONCHITIS VIRUS; MEMBRANE GLYCOPROTEINS; MUTAGENESIS, SITE-DIRECTED; VERO CELLS; VIRAL ENVELOPE PROTEINS; VIRUS INTERNALIZATION;

EID: 69249215352     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00613-09     Document Type: Article

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