Elastase-mediated activation of the severe acute respiratory syndrome coronavirus spike protein at discrete sites within the S2 domain

Journal of Biological Chemistry

Volumn 285, Issue 30, 2010, Pages 22758-22763

  Belouzard, Sandrine ^a   Madu, Ikenna ^a   Whittaker, Gary R ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLEAVAGE SITES; ELASTASE; FUSION PEPTIDES; FUSION PROTEINS; HOST CELLS; MEMBRANE FUSION; PROTEOLYTIC CLEAVAGE; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS; SPIKE PROTEIN; VIRAL PATHOGENESIS;

CELL MEMBRANES; GLYCOSYLATION;

PROTEINS;

ALANINE; ELASTASE; HYBRID PROTEIN; THREONINE; VIRUS SPIKE PROTEIN;

ARTICLE; CELL FUSION; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; SARS CORONAVIRUS; VERO CELL; VIRUS CELL INTERACTION; VIRUS PATHOGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATTLE; CELL FUSION; CERCOPITHECUS AETHIOPS; HUMANS; MEMBRANE GLYCOPROTEINS; MUTAGENESIS; MUTATION; PANCREATIC ELASTASE; PROTEIN STRUCTURE, TERTIARY; SARS VIRUS; TRYPSIN; VERO CELLS; VIRAL ENVELOPE PROTEINS;

SARS CORONAVIRUS;

EID: 77954915034     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.103275     Document Type: Article

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