25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

Nature Communications

Volumn 7, Issue , 2016, Pages

  Jang, Jiho ^a   Park, Sangjun ^a   Jin Hur, Hye ^a   Cho, Hyun Ju ^a   Hwang, Inhwa ^a   Pyo Kang, Yun ^b   Im, Isak ^a   Lee, Hyunji ^a   Lee, Eunju ^a   Yang, Wonsuk ^a   Kang, Hoon Chul ^c   Won Kwon, Sung ^b   Yu, Je Wook ^a   Kim, Dong Wook ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYCHOLESTEROL; CRYOPYRIN; INTERLEUKIN 1BETA; LIVER X RECEPTOR; REACTIVE OXYGEN METABOLITE; 25-HYDROXYCHOLESTEROL; ABC TRANSPORTER D1; ABCD1 PROTEIN, HUMAN; CHOLESTEROL 25-HYDROXYLASE; CHOLESTEROL DERIVATIVE; INFLAMMASOME; NLRP3 PROTEIN, HUMAN; STEROID MONOOXYGENASE;

BRAIN; CELLS AND CELL COMPONENTS; ENZYME; ENZYME ACTIVITY; FATTY ACID; MUTATION; NERVOUS SYSTEM DISORDER; ORGANIC COMPOUND; PROTEIN; REACTIVE OXYGEN SPECIES; RODENT;

ADRENOLEUKODYSTROPHY; ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; CORPUS CALLOSUM; CYTOKINE PRODUCTION; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OLIGODENDROGLIA; PATHOGENESIS; POTASSIUM TRANSPORT; UPREGULATION; X CHROMOSOME LINKED DISORDER; AGONISTS; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DEFICIENCY; DRUG EFFECT; GENETICS; INFLAMMATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PRIMARY CELL CULTURE; STEREOTACTIC PROCEDURE; WHITE MATTER;

ADRENOLEUKODYSTROPHY; ANIMALS; ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY D, MEMBER 1; CORPUS CALLOSUM; FIBROBLASTS; GENE EXPRESSION; HYDROXYCHOLESTEROLS; INDUCED PLURIPOTENT STEM CELLS; INFLAMMASOMES; INFLAMMATION; INJECTIONS, INTRAVENTRICULAR; LIVER X RECEPTORS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; OLIGODENDROGLIA; PRIMARY CELL CULTURE; REACTIVE OXYGEN SPECIES; STEREOTAXIC TECHNIQUES; STEROID HYDROXYLASES; WHITE MATTER;

EID: 84992200597     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13129     Document Type: Article

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