-
1
-
-
77950362382
-
The inflammasomes
-
Schroder, K. & Tschopp, J. The inflammasomes. Cell 140, 821-832 (2010).
-
(2010)
Cell
, vol.140
, pp. 821-832
-
-
Schroder, K.1
Tschopp, J.2
-
2
-
-
84858677223
-
Sensing and reacting to microbes through the inflammasomes
-
Franchi, L., Munoz-Planillo, R. & Nunez, G. Sensing and reacting to microbes through the inflammasomes. Nat Immunol 13, 325-332 (2012).
-
(2012)
Nat Immunol
, vol.13
, pp. 325-332
-
-
Franchi, L.1
Munoz-Planillo, R.2
Nunez, G.3
-
3
-
-
84894196760
-
Inflammasomes and metabolic disease
-
Henao-Mejia, J., Elinav, E., Thaiss, C. A. & Flavell, R. A. Inflammasomes and metabolic disease. Annu Rev Physiol 76, 57-78 (2014).
-
(2014)
Annu Rev Physiol
, vol.76
, pp. 57-78
-
-
Henao-Mejia, J.1
Elinav, E.2
Thaiss, C.A.3
Flavell, R.A.4
-
4
-
-
84858630049
-
A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation?
-
Wen, H., Ting, J. P. & O'Neill, L. A. A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation? Nat Immunol 13, 352-357 (2012).
-
(2012)
Nat Immunol
, vol.13
, pp. 352-357
-
-
Wen, H.1
Ting, J.P.2
O'Neill, L.A.3
-
5
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
Zhou, R., Yazdi, A. S., Menu, P. & Tschopp, J. A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221-225 (2011).
-
(2011)
Nature
, vol.469
, pp. 221-225
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
6
-
-
84924585055
-
Mitochondria: Diversity in the regulation of the NLRP3 inflammasome
-
Gurung, P., Lukens, J. R. & Kanneganti, T. D. Mitochondria: diversity in the regulation of the NLRP3 inflammasome. Trends Mol Med, doi: 10. 1016/j. molmed. 2014. 11. 008. (2014).
-
(2014)
Trends Mol Med
-
-
Gurung, P.1
Lukens, J.R.2
Kanneganti, T.D.3
-
7
-
-
79951642032
-
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
-
Nakahira, K. et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 12, 222-230 (2011).
-
(2011)
Nat Immunol
, vol.12
, pp. 222-230
-
-
Nakahira, K.1
-
8
-
-
84885437002
-
The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity
-
Park, S. et al. The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity. J Immunol 191, 4358-4366 (2013).
-
(2013)
J Immunol
, vol.191
, pp. 4358-4366
-
-
Park, S.1
-
9
-
-
84876237736
-
The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation
-
Subramanian, N., Natarajan, K., Clatworthy, M. R., Wang, Z. & Germain, R. N. The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell 153, 348-361 (2013).
-
(2013)
Cell
, vol.153
, pp. 348-361
-
-
Subramanian, N.1
Natarajan, K.2
Clatworthy, M.R.3
Wang, Z.4
Germain, R.N.5
-
10
-
-
84887086945
-
Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection
-
Ichinohe, T., Yamazaki, T., Koshiba, T. & Yanagi, Y. Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection. Proc Natl Acad Sci USA 110, 17963-17968 (2013).
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 17963-17968
-
-
Ichinohe, T.1
Yamazaki, T.2
Koshiba, T.3
Yanagi, Y.4
-
11
-
-
77955351652
-
New insights into the role of mitochondria in aging: Mitochondrial dynamics and more
-
Seo, A. Y., Joseph, A. M., Dutta, D., Hwang, J. C., Aris, J. P. & Leeuwenburgh, C. New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci 123, 2533-2542 (2010).
-
(2010)
J Cell Sci
, vol.123
, pp. 2533-2542
-
-
Seo, A.Y.1
Joseph, A.M.2
Dutta, D.3
Hwang, J.C.4
Aris, J.P.5
Leeuwenburgh, C.6
-
12
-
-
67650868959
-
Mitochondrial dynamics in mammalian health and disease
-
Liesa, M., Palacin, M. & Zorzano, A. Mitochondrial dynamics in mammalian health and disease. Physiol Rev 89, 799-845 (2009).
-
(2009)
Physiol Rev
, vol.89
, pp. 799-845
-
-
Liesa, M.1
Palacin, M.2
Zorzano, A.3
-
13
-
-
70350468688
-
Mitofusin 2 inhibits mitochondrial antiviral signaling
-
Yasukawa, K. et al. Mitofusin 2 inhibits mitochondrial antiviral signaling. Sci Signal 2, ra47 (2009).
-
(2009)
Sci Signal
, vol.2
, pp. ra47
-
-
Yasukawa, K.1
-
14
-
-
75949098312
-
Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway
-
Castanier, C., Garcin, D., Vazquez, A. & Arnoult, D. Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway. EMBO Rep 11, 133-138 (2010).
-
(2010)
EMBO Rep
, vol.11
, pp. 133-138
-
-
Castanier, C.1
Garcin, D.2
Vazquez, A.3
Arnoult, D.4
-
15
-
-
77957666242
-
Virus-infection or 5? Ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1
-
Onoguchi, K. et al. Virus-infection or 5? ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1. PLoS Pathog 6, e1001012 (2010).
-
(2010)
PLoS Pathog
, vol.6
, pp. e1001012
-
-
Onoguchi, K.1
-
16
-
-
5444236916
-
Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1
-
Varadi, A., Johnson-Cadwell, L. I., Cirulli, V., Yoon, Y., Allan, V. J. & Rutter, G. A. Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1. J Cell Sci 117, 4389-4400 (2004).
-
(2004)
J Cell Sci
, vol.117
, pp. 4389-4400
-
-
Varadi, A.1
Johnson-Cadwell, L.I.2
Cirulli, V.3
Yoon, Y.4
Allan, V.J.5
Rutter, G.A.6
-
17
-
-
48749085779
-
Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients
-
Wang, X., Su, B., Fujioka, H. & Zhu, X. Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients. Am J Pathol 173, 470-482 (2008).
-
(2008)
Am J Pathol
, vol.173
, pp. 470-482
-
-
Wang, X.1
Su, B.2
Fujioka, H.3
Zhu, X.4
-
18
-
-
34548031870
-
The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
-
Fernandes-Alnemri, T. et al. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ 14, 1590-1604 (2007).
-
(2007)
Cell Death Differ
, vol.14
, pp. 1590-1604
-
-
Fernandes-Alnemri, T.1
-
19
-
-
64849097220
-
Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain
-
Bryan, N. B., Dorfleutner, A., Rojanasakul, Y. & Stehlik, C. Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain. J Immunol 182, 3173-3182 (2009).
-
(2009)
J Immunol
, vol.182
, pp. 3173-3182
-
-
Bryan, N.B.1
Dorfleutner, A.2
Rojanasakul, Y.3
Stehlik, C.4
-
20
-
-
84936847396
-
Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4
-
Hwang, I. et al. Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4. Immunol Cell Biol 93, 591-599 (2015).
-
(2015)
Immunol Cell Biol
, vol.93
, pp. 591-599
-
-
Hwang, I.1
-
21
-
-
0035487808
-
The role of dynamin-related protein 1 a mediator of mitochondrial fission, in apoptosis
-
Frank, S. et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell 1, 515-525 (2001).
-
(2001)
Dev Cell
, vol.1
, pp. 515-525
-
-
Frank, S.1
-
22
-
-
84876048788
-
Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation
-
Din, S. et al. Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation. Proc Natl Acad Sci USA 110, 5969-5974 (2013).
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 5969-5974
-
-
Din, S.1
-
23
-
-
84862909353
-
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways
-
Wang, Z., Jiang, H., Chen, S., Du, F. & Wang, X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148, 228-243 (2012).
-
(2012)
Cell
, vol.148
, pp. 228-243
-
-
Wang, Z.1
Jiang, H.2
Chen, S.3
Du, F.4
Wang, X.5
-
24
-
-
84896802122
-
Necroptosis induced by RIPK3 requires MLKL but not Drp1
-
Moujalled, D. M., Cook, W. D., Murphy, J. M. & Vaux, D. L. Necroptosis induced by RIPK3 requires MLKL but not Drp1. Cell Death Dis 5, e1086 (2014).
-
(2014)
Cell Death Dis
, vol.5
, pp. e1086
-
-
Moujalled, D.M.1
Cook, W.D.2
Murphy, J.M.3
Vaux, D.L.4
-
25
-
-
84882280029
-
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
-
Sagulenko, V. et al. AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death Differ 20, 1149-1160 (2013).
-
(2013)
Cell Death Differ
, vol.20
, pp. 1149-1160
-
-
Sagulenko, V.1
-
26
-
-
84906852294
-
Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming
-
Allam, R. et al. Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO Rep 15, 982-990 (2014).
-
(2014)
EMBO Rep
, vol.15
, pp. 982-990
-
-
Allam, R.1
-
27
-
-
68249087424
-
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice
-
Ishihara, N. et al. Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol 11, 958-966 (2009).
-
(2009)
Nat Cell Biol
, vol.11
, pp. 958-966
-
-
Ishihara, N.1
-
28
-
-
84867770402
-
Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation
-
Juliana, C., Fernandes-Alnemri, T., Kang, S., Farias, A., Qin, F. & Alnemri, E. S. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem 287, 36617-36622 (2012).
-
(2012)
J Biol Chem
, vol.287
, pp. 36617-36622
-
-
Juliana, C.1
Fernandes-Alnemri, T.2
Kang, S.3
Farias, A.4
Qin, F.5
Alnemri, E.S.6
-
29
-
-
84911192502
-
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
-
Wang, X. et al. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol 15, 1126-1133 (2014).
-
(2014)
Nat Immunol
, vol.15
, pp. 1126-1133
-
-
Wang, X.1
-
30
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
Narendra, D., Tanaka, A., Suen, D. F. & Youle, R. J. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183, 795-803 (2008).
-
(2008)
J Cell Biol
, vol.183
, pp. 795-803
-
-
Narendra, D.1
Tanaka, A.2
Suen, D.F.3
Youle, R.J.4
-
31
-
-
84878237993
-
Activation and regulation of the inflammasomes
-
Latz, E., Xiao, T. S. & Stutz, A. Activation and regulation of the inflammasomes. Nat Rev Immunol 13, 397-411 (2013).
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 397-411
-
-
Latz, E.1
Xiao, T.S.2
Stutz, A.3
-
32
-
-
84908544666
-
Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy
-
Yu, J. et al. Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. Proc Natl Acad Sci USA 111, 15514-15519 (2014).
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 15514-15519
-
-
Yu, J.1
-
33
-
-
84898635026
-
Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function
-
Ghonime, M. G. et al. Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function. J Immunol 192, 3881-3888 (2014).
-
(2014)
J Immunol
, vol.192
, pp. 3881-3888
-
-
Ghonime, M.G.1
-
34
-
-
70449591270
-
A new paradigm for MAPK: Structural interactions of hERK1 with mitochondria in HeLa cells
-
Galli, S. et al. A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells. PLoS One 4, e7541 (2009).
-
(2009)
PLoS One
, vol.4
, pp. e7541
-
-
Galli, S.1
-
35
-
-
79955714439
-
New algorithm to determine true colocalization in combination with image restoration and time-lapse confocal microscopy to MAP kinases in mitochondria
-
Villalta, J. I. et al. New algorithm to determine true colocalization in combination with image restoration and time-lapse confocal microscopy to MAP kinases in mitochondria. PLoS One 6, e19031 (2011).
-
(2011)
PLoS One
, vol.6
, pp. e19031
-
-
Villalta, J.I.1
-
36
-
-
84910141948
-
Mitochondrial dynamics and inheritance during cell division, development and disease
-
Mishra, P. & Chan, D. C. Mitochondrial dynamics and inheritance during cell division, development and disease. Nat Rev Mol Cell Biol 15, 634-646 (2014).
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, pp. 634-646
-
-
Mishra, P.1
Chan, D.C.2
-
37
-
-
34247525092
-
A lethal defect of mitochondrial and peroxisomal fission
-
Waterham, H. R., Koster, J., van Roermund, C. W., Mooyer, P. A., Wanders, R. J. & Leonard, J. V. A lethal defect of mitochondrial and peroxisomal fission. N Engl J Med 356, 1736-1741 (2007).
-
(2007)
N Engl J Med
, vol.356
, pp. 1736-1741
-
-
Waterham, H.R.1
Koster, J.2
Van Roermund, C.W.3
Mooyer, P.A.4
Wanders, R.J.5
Leonard, J.V.6
-
38
-
-
84865352799
-
Tau promotes neurodegeneration via DRP1 mislocalization in vivo
-
DuBoff, B., Gotz, J. & Feany, M. B. Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron 75, 618-632 (2012).
-
(2012)
Neuron
, vol.75
, pp. 618-632
-
-
DuBoff, B.1
Gotz, J.2
Feany, M.B.3
-
39
-
-
84903269246
-
Innate immune activation in neurodegenerative disease
-
Heneka, M. T., Kummer, M. P. & Latz, E. Innate immune activation in neurodegenerative disease. Nat Rev Immunol 14, 463-477 (2014).
-
(2014)
Nat Rev Immunol
, vol.14
, pp. 463-477
-
-
Heneka, M.T.1
Kummer, M.P.2
Latz, E.3
-
40
-
-
79957597757
-
Mitochondria in innate immune responses
-
West, A. P., Shadel, G. S. & Ghosh, S. Mitochondria in innate immune responses. Nat Rev Immunol 11, 389-402 (2011).
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 389-402
-
-
West, A.P.1
Shadel, G.S.2
Ghosh, S.3
-
41
-
-
77951263260
-
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
-
Fernandes-Alnemri, T. et al. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol 11, 385-393 (2010).
-
(2010)
Nat Immunol
, vol.11
, pp. 385-393
-
-
Fernandes-Alnemri, T.1
-
42
-
-
63649145255
-
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
-
Fernandes-Alnemri, T., Yu, J. W., Datta, P., Wu, J. & Alnemri, E. S. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458, 509-513 (2009).
-
(2009)
Nature
, vol.458
, pp. 509-513
-
-
Fernandes-Alnemri, T.1
Yu, J.W.2
Datta, P.3
Wu, J.4
Alnemri, E.S.5
-
43
-
-
35348934890
-
Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants
-
Yu, J. W. et al. Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Mol Cell 28, 214-227 (2007).
-
(2007)
Mol Cell
, vol.28
, pp. 214-227
-
-
Yu, J.W.1
|