25-Hydroxycholesterol induces mitochondria-dependent apoptosis via activation of glycogen synthase kinase-3β in PC12 cells

Free Radical Research

Volumn 42, Issue 6, 2008, Pages 544-553

  Choi, Y K ^a   Kim, Y S ^a   Choi, I Y ^b   Kim, S W ^c   Kim, W K ^b  

^a Seoul National University   (South Korea)

^b Korea University College of Medicine   (South Korea)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

25 Hydroxycholesterol; Caspase; GSK 3 ; JNK

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; 25 HYDROXYCHOLESTEROL; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 9; CYTOCHROME C; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NONHUMAN; PHEOCHROMOCYTOMA CELL; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTHRACENES; APOPTOSIS; CASPASE 3; CASPASE 9; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOGEN SYNTHASE KINASE 3; HYDROXYCHOLESTEROLS; MAP KINASE KINASE 4; MITOCHONDRIA; MODELS, BIOLOGICAL; PC12 CELLS; RATS; SIGNAL TRANSDUCTION;

EID: 46649102457     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760802146062     Document Type: Article

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