Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation

Journal of Biological Chemistry

Volumn 290, Issue 45, 2015, Pages 27425-27437

  Won, Ji Hee ^a   Park, Sangjun ^a   Hong, Sujeong ^a   Son, Seunghwan ^a   Yu, Je Wook ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHAINS; ELECTRON TRANSPORT PROPERTIES; FLAVONOIDS;

DEGENERATIVE DISEASE; HIGH GRADES; HYPERPOLARIZATION; INFLAMMASOME; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL ELECTRON TRANSPORT CHAIN;

CHEMICAL ACTIVATION;

ADENOSINE TRIPHOSPHATE; ALUMINUM POTASSIUM SULFATE; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOCHONDRIAL DNA; NIGERICIN; PEPTIDES AND PROTEINS; POTASSIUM; PROTEIN ASC; REACTIVE OXYGEN METABOLITE; ROTENONE; UNCLASSIFIED DRUG; CARRIER PROTEIN; MULTIENZYME COMPLEX; NLRP3 PROTEIN, MOUSE; UNCOUPLING PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOSOL; DEUBIQUITINATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; HYPERPOLARIZATION; MITOCHONDRIAL ENERGY TRANSFER; MOUSE; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN MODIFICATION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; ELECTRON TRANSPORT; GENETICS; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARRIER PROTEINS; CASPASE 1; CELLS, CULTURED; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; INFLAMMASOMES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; REACTIVE OXYGEN SPECIES; ROTENONE; UNCOUPLING AGENTS;

EID: 84946771274     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.667063     Document Type: Article

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