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Volumn 10, Issue MAR, 2016, Pages

Environmental enrichment, age, and Pparα interact to regulate proliferation in neurogenic niches

Author keywords

Aging; Environment; Hippocampus; Neurogenesis; Ppar ; Subventricular zone

Indexed keywords

BROXURIDINE; DOUBLECORTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

EID: 84964318278     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2016.00089     Document Type: Article
Times cited : (17)

References (69)
  • 1
    • 73349120950 scopus 로고    scopus 로고
    • Age-dependent alteration in hippocampal neurogenesis correlates with learning performance of macaque monkeys
    • Aizawa, K., Ageyama, N., Yokoyama, C., and Hisatsune, T. (2009). Age-dependent alteration in hippocampal neurogenesis correlates with learning performance of macaque monkeys. Exp. Anim. 58, 403-407. doi: 10.1538/expanim.58.403
    • (2009) Exp. Anim , vol.58 , pp. 403-407
    • Aizawa, K.1    Ageyama, N.2    Yokoyama, C.3    Hisatsune, T.4
  • 3
    • 84888083879 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptors (PPAR)-alpha, beta/delta and gamma triad in regulation of reactive oxygen species signaling in brain
    • Aleshin, S., and Reiser, G. (2013). Role of the peroxisome proliferator-activated receptors (PPAR)-alpha, beta/delta and gamma triad in regulation of reactive oxygen species signaling in brain. Biol. Chem. 394, 1553-1570. doi: 10.1515/hsz-2013-0215
    • (2013) Biol. Chem , vol.394 , pp. 1553-1570
    • Aleshin, S.1    Reiser, G.2
  • 4
    • 1542268981 scopus 로고    scopus 로고
    • For the long run: maintaining germinal niches in the adult brain
    • Alvarez-Buylla, A., and Lim, D. A. (2004). For the long run: maintaining germinal niches in the adult brain. Neuron 41, 683-686. doi: 10.1016/S0896-6273(04)00111-4
    • (2004) Neuron , vol.41 , pp. 683-686
    • Alvarez-Buylla, A.1    Lim, D.A.2
  • 5
    • 84941730988 scopus 로고    scopus 로고
    • Signaling mechanisms mediating the regulation of synaptic plasticity and memory by estradiol
    • Arevalo, M. A., Azcoitia, I., Gonzalez-Burgos, I., and Garcia-Segura, L. M. (2015). Signaling mechanisms mediating the regulation of synaptic plasticity and memory by estradiol. Horm. Behav. 74, 19-27. doi: 10.1016/j.yhbeh.2015.04.016
    • (2015) Horm. Behav , vol.74 , pp. 19-27
    • Arevalo, M.A.1    Azcoitia, I.2    Gonzalez-Burgos, I.3    Garcia-Segura, L.M.4
  • 7
    • 0036735672 scopus 로고    scopus 로고
    • Neuronal replacement from endogenous precursors in the adult brain after stroke
    • Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., and Lindvall, O. (2002). Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 8, 963-970. doi: 10.1038/nm747
    • (2002) Nat. Med , vol.8 , pp. 963-970
    • Arvidsson, A.1    Collin, T.2    Kirik, D.3    Kokaia, Z.4    Lindvall, O.5
  • 8
    • 0036082713 scopus 로고    scopus 로고
    • NMDA receptor activation mediates hydrogen peroxide-induced pathophysiology in rat hippocampal slices
    • Avshalumov, M. V., and Rice, M. E. (2002). NMDA receptor activation mediates hydrogen peroxide-induced pathophysiology in rat hippocampal slices. J. Neurophysiol. 87, 2896-2903. doi: 10.1152/jn.01011.2001
    • (2002) J. Neurophysiol , vol.87 , pp. 2896-2903
    • Avshalumov, M.V.1    Rice, M.E.2
  • 10
    • 35248894807 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha is required for the neurotrophic effect of oleic acid in neurons
    • Bento-Abreu, A., Tabernero, A., and Medina, J. M. (2007). Peroxisome proliferator-activated receptor-alpha is required for the neurotrophic effect of oleic acid in neurons. J. Neurochem. 103, 871-881. doi: 10.1111/j.1471-4159.2007.04807.x
    • (2007) J. Neurochem , vol.103 , pp. 871-881
    • Bento-Abreu, A.1    Tabernero, A.2    Medina, J.M.3
  • 12
    • 0042668324 scopus 로고    scopus 로고
    • Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline
    • Bizon, J. L., and Gallagher, M. (2003). Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline. Eur. J. Neurosci. 18, 215-219. doi: 10.1046/j.1460-9568.2003.02733.x
    • (2003) Eur. J. Neurosci , vol.18 , pp. 215-219
    • Bizon, J.L.1    Gallagher, M.2
  • 13
    • 84892591249 scopus 로고    scopus 로고
    • Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat
    • Blanco-Calvo, E., Rivera, P., Arrabal, S., Vargas, A., Pavón, F. J., Serrano, A., et al. (2014). Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat. Front. Integr. Neurosci. 7:106. doi: 10.3389/fnint.2013.00106
    • (2014) Front. Integr. Neurosci , vol.7 , pp. 106
    • Blanco-Calvo, E.1    Rivera, P.2    Arrabal, S.3    Vargas, A.4    Pavón, F.J.5    Serrano, A.6
  • 14
  • 15
    • 84941007478 scopus 로고    scopus 로고
    • Inflammation without neuronal death triggers striatal neurogenesis comparable to stroke
    • Chapman, K. Z., Ge, R., Monni, E., Tatarishvili, J., Ahlenius, H., Arvidsson, A., et al. (2015). Inflammation without neuronal death triggers striatal neurogenesis comparable to stroke. Neurobiol. Dis. 83, 1-15. doi: 10.1016/j.nbd.2015.08.013
    • (2015) Neurobiol. Dis , vol.83 , pp. 1-15
    • Chapman, K.Z.1    Ge, R.2    Monni, E.3    Tatarishvili, J.4    Ahlenius, H.5    Arvidsson, A.6
  • 16
    • 58149401447 scopus 로고    scopus 로고
    • Emerging roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of neural stem cells proliferation and differentiation
    • Cimini, A., and Ceru, M. P. (2008). Emerging roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of neural stem cells proliferation and differentiation. Stem Cell Rev. 4, 293-303. doi: 10.1007/s12015-008-9024-2
    • (2008) Stem Cell Rev , vol.4 , pp. 293-303
    • Cimini, A.1    Ceru, M.P.2
  • 17
    • 34447516653 scopus 로고    scopus 로고
    • PPARs expression in adult mouse neural stem cells: modulation of PPARs during astroglial differentiaton of NSC
    • Cimini, A., Cristiano, L., Benedetti, E., D'Angelo, B., and Ceru, M. P. (2007). PPARs expression in adult mouse neural stem cells: modulation of PPARs during astroglial differentiaton of NSC. PPAR Res. 2007:48242. doi: 10.1155/2007/48242
    • (2007) PPAR Res , vol.2007 , pp. 48242
    • Cimini, A.1    Cristiano, L.2    Benedetti, E.3    D'Angelo, B.4    Ceru, M.P.5
  • 18
    • 78049467264 scopus 로고    scopus 로고
    • Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans
    • Coras, R., Siebzehnrubl, F. A., Pauli, E., Huttner, H. B., Njunting, M., Kobow, K., et al. (2010). Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans. Brain 133, 3359-3372. doi: 10.1093/brain/awq215
    • (2010) Brain , vol.133 , pp. 3359-3372
    • Coras, R.1    Siebzehnrubl, F.A.2    Pauli, E.3    Huttner, H.B.4    Njunting, M.5    Kobow, K.6
  • 19
    • 13844308524 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs) and related transcription factors in differentiating astrocyte cultures
    • Cristiano, L., Cimini, A., Moreno, S., Ragnelli, A. M., and Paola Ceru, M. (2005). Peroxisome proliferator-activated receptors (PPARs) and related transcription factors in differentiating astrocyte cultures. Neuroscience 131, 577-587. doi: 10.1016/j.neuroscience.2004.11.008
    • (2005) Neuroscience , vol.131 , pp. 577-587
    • Cristiano, L.1    Cimini, A.2    Moreno, S.3    Ragnelli, A.M.4    Paola Ceru, M.5
  • 20
    • 27744581486 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 reduces age-related disorders induced by prenatal stress in female rats
    • Darnaudéry, M., Perez-Martin, M., Bélizaire, G., Maccari, S., and Garcia-Segura, L. M. (2006). Insulin-like growth factor 1 reduces age-related disorders induced by prenatal stress in female rats. Neurobiol. Aging 27, 119-127. doi: 10.1016/j.neurobiolaging.2005.01.008
    • (2006) Neurobiol. Aging , vol.27 , pp. 119-127
    • Darnaudéry, M.1    Perez-Martin, M.2    Bélizaire, G.3    Maccari, S.4    Garcia-Segura, L.M.5
  • 21
    • 0242321829 scopus 로고    scopus 로고
    • The glial identity of neural stem cells
    • Doetsch, F. (2003a). The glial identity of neural stem cells. Nat. Neurosci. 6, 1127-1134. doi: 10.1038/nn1144
    • (2003) Nat. Neurosci , vol.6 , pp. 1127-1134
    • Doetsch, F.1
  • 22
    • 0141785164 scopus 로고    scopus 로고
    • A niche for adult neural stem cells
    • Doetsch, F. (2003b). A niche for adult neural stem cells. Curr. Opin. Genet. Dev. 13, 543-550. doi: 10.1016/j.gde.2003.08.012
    • (2003) Curr. Opin. Genet. Dev , vol.13 , pp. 543-550
    • Doetsch, F.1
  • 23
    • 0033613135 scopus 로고    scopus 로고
    • Regeneration of a germinal layer in the adult mammalian brain
    • Doetsch, F., Garcia-Verdugo, J. M., and Alvarez-Buylla, A. (1999). Regeneration of a germinal layer in the adult mammalian brain. Proc. Natl. Acad. Sci. U.S.A. 96, 11619-11624. doi: 10.1073/pnas.96.20.11619
    • (1999) Proc. Natl. Acad. Sci. U.S.A , vol.96 , pp. 11619-11624
    • Doetsch, F.1    Garcia-Verdugo, J.M.2    Alvarez-Buylla, A.3
  • 24
    • 0344198502 scopus 로고    scopus 로고
    • Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis
    • Drapeau, E., Mayo, W., Aurousseau, C., Le Moal, M., Piazza, P. V., and Abrous, D. N. (2003). Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis. Proc. Natl. Acad. Sci. U.S.A. 100, 14385-14390. doi: 10.1073/pnas.2334169100
    • (2003) Proc. Natl. Acad. Sci. U.S.A , vol.100 , pp. 14385-14390
    • Drapeau, E.1    Mayo, W.2    Aurousseau, C.3    Le Moal, M.4    Piazza, P.V.5    Abrous, D.N.6
  • 25
    • 33846203884 scopus 로고    scopus 로고
    • Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation
    • Fan, Y., Liu, Z., Weinstein, P. R., Fike, J. R., and Liu, J. (2007). Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation. Eur. J. Neurosci. 25, 38-46. doi: 10.1111/j.1460-9568.2006.05269.x
    • (2007) Eur. J. Neurosci , vol.25 , pp. 38-46
    • Fan, Y.1    Liu, Z.2    Weinstein, P.R.3    Fike, J.R.4    Liu, J.5
  • 26
    • 84884699932 scopus 로고    scopus 로고
    • Spinal cord injury induced changes of nuclear receptors PPARalpha and LXRbeta and modulation with oleic acid/albumin treatment
    • Fandel, D., Wasmuht, D., Avila-Martin, G., Taylor, J. S., Galan-Arriero, I., and Mey, J. (2013). Spinal cord injury induced changes of nuclear receptors PPARalpha and LXRbeta and modulation with oleic acid/albumin treatment. Brain Res. 1535, 89-105. doi: 10.1016/j.brainres.2013.08.022
    • (2013) Brain Res , vol.1535 , pp. 89-105
    • Fandel, D.1    Wasmuht, D.2    Avila-Martin, G.3    Taylor, J.S.4    Galan-Arriero, I.5    Mey, J.6
  • 27
    • 84903688936 scopus 로고    scopus 로고
    • Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARalpha) and its lipid ligands
    • Fidaleo, M., Fanelli, F., Ceru, M. P., and Moreno, S. (2014). Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARalpha) and its lipid ligands. Curr. Med. Chem. 21, 2803-2821. doi: 10.2174/0929867321666140303143455
    • (2014) Curr. Med. Chem , vol.21 , pp. 2803-2821
    • Fidaleo, M.1    Fanelli, F.2    Ceru, M.P.3    Moreno, S.4
  • 29
    • 84956808068 scopus 로고    scopus 로고
    • Mice in an enriched environment learn more flexibly because of adult hippocampal neurogenesis
    • Garthe, A., Roeder, I., and Kempermann, G. (2016). Mice in an enriched environment learn more flexibly because of adult hippocampal neurogenesis. Hippocampus 26, 261-271. doi: 10.1002/hipo.22520
    • (2016) Hippocampus , vol.26 , pp. 261-271
    • Garthe, A.1    Roeder, I.2    Kempermann, G.3
  • 30
    • 84897852790 scopus 로고    scopus 로고
    • The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism
    • González-Aparicio, R., Blanco, E., Serrano, A., Pavon, F. J., Parsons, L. H., Maldonado, R., et al. (2014). The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism. Int. J. Neuropsychopharmacol. 17, 455-468. doi: 10.1017/S1461145713001259
    • (2014) Int. J. Neuropsychopharmacol , vol.17 , pp. 455-468
    • González-Aparicio, R.1    Blanco, E.2    Serrano, A.3    Pavon, F.J.4    Parsons, L.H.5    Maldonado, R.6
  • 31
    • 84866280256 scopus 로고    scopus 로고
    • Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal peroxisome proliferator activated receptors (PPARalpha and PPARgamma) gene expression in rats
    • Hajjar, T., Meng, G. Y., Rajion, M. A., Vidyadaran, S., Othman, F., Farjam, A. S., et al. (2012). Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal peroxisome proliferator activated receptors (PPARalpha and PPARgamma) gene expression in rats. BMC Neurosci. 13:109. doi: 10.1186/1471-2202-13-109
    • (2012) BMC Neurosci , vol.13 , pp. 109
    • Hajjar, T.1    Meng, G.Y.2    Rajion, M.A.3    Vidyadaran, S.4    Othman, F.5    Farjam, A.S.6
  • 32
    • 34548494847 scopus 로고    scopus 로고
    • Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders
    • Heneka, M. T., Landreth, G. E., and Hull, M. (2007). Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders. Nat. Clin. Pract. Neurol. 3, 496-504. doi: 10.1038/ncpneuro0586
    • (2007) Nat. Clin. Pract. Neurol , vol.3 , pp. 496-504
    • Heneka, M.T.1    Landreth, G.E.2    Hull, M.3
  • 33
    • 84944346032 scopus 로고    scopus 로고
    • Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment
    • Kondo, H., Kurahashi, M., Mori, D., Iinuma, M., Tamura, Y., Mizutani, K., et al. (2015). Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment. Arch. Oral Biol. 61, 1-7. doi: 10.1016/j.archoralbio.2015.10.006
    • (2015) Arch. Oral Biol , vol.61 , pp. 1-7
    • Kondo, H.1    Kurahashi, M.2    Mori, D.3    Iinuma, M.4    Tamura, Y.5    Mizutani, K.6
  • 34
    • 0029863342 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
    • Kuhn, H. G., Dickinson-Anson, H., and Gage, F. H. (1996). Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16, 2027-2033
    • (1996) J. Neurosci , vol.16 , pp. 2027-2033
    • Kuhn, H.G.1    Dickinson-Anson, H.2    Gage, F.H.3
  • 35
    • 77958537621 scopus 로고    scopus 로고
    • Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment
    • Kuzumaki, N., Ikegami, D., Tamura, R., Hareyama, N., Imai, S., Narita, M., et al. (2011). Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment. Hippocampus 21, 127-132. doi: 10.1002/hipo.20775
    • (2011) Hippocampus , vol.21 , pp. 127-132
    • Kuzumaki, N.1    Ikegami, D.2    Tamura, R.3    Hareyama, N.4    Imai, S.5    Narita, M.6
  • 36
    • 0346868807 scopus 로고    scopus 로고
    • Neurogenesis in the adult brain: new strategies for central nervous system diseases
    • Lie, D. C., Song, H., Colamarino, S. A., Ming, G. L., and Gage, F. H. (2004). Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu. Rev. Pharmacol. Toxicol. 44, 399-421. doi: 10.1146/annurev.pharmtox.44.101802.121631
    • (2004) Annu. Rev. Pharmacol. Toxicol , vol.44 , pp. 399-421
    • Lie, D.C.1    Song, H.2    Colamarino, S.A.3    Ming, G.L.4    Gage, F.H.5
  • 37
    • 84919830696 scopus 로고    scopus 로고
    • Neurogenesis is enhanced by stroke in multiple new stem cell niches along the ventricular system at sites of high BBB permeability
    • Lin, R., Cai, J., Nathan, C., Wei, X., Schleidt, S., Rosenwasser, R., et al. (2015). Neurogenesis is enhanced by stroke in multiple new stem cell niches along the ventricular system at sites of high BBB permeability. Neurobiol. Dis. 74, 229-239. doi: 10.1016/j.nbd.2014.11.016
    • (2015) Neurobiol. Dis , vol.74 , pp. 229-239
    • Lin, R.1    Cai, J.2    Nathan, C.3    Wei, X.4    Schleidt, S.5    Rosenwasser, R.6
  • 38
    • 84952639634 scopus 로고    scopus 로고
    • Classic and novel stem cell niches in brain homeostasis and repair
    • Lin, R., and Iacovitti, L. (2015). Classic and novel stem cell niches in brain homeostasis and repair. Brain Res. 1628(Pt B), 327-342. doi: 10.1016/j.brainres.2015.04.029
    • (2015) Brain Res , vol.1628 , pp. 327-342
    • Lin, R.1    Iacovitti, L.2
  • 39
    • 84920623734 scopus 로고    scopus 로고
    • Neurodevelopmental origin and adult neurogenesis of the neuroendocrine hypothalamus
    • Maggi, R., Zasso, J., and Conti, L. (2014). Neurodevelopmental origin and adult neurogenesis of the neuroendocrine hypothalamus. Front. Cell. Neurosci. 8:440. doi: 10.3389/fncel.2014.00440
    • (2014) Front. Cell. Neurosci , vol.8 , pp. 440
    • Maggi, R.1    Zasso, J.2    Conti, L.3
  • 40
    • 21344464438 scopus 로고    scopus 로고
    • Dynamics of neurogenesis in the dentate gyrus of adult rats
    • McDonald, H. Y., and Wojtowicz, J. M. (2005). Dynamics of neurogenesis in the dentate gyrus of adult rats. Neurosci. Lett. 385, 70-75. doi: 10.1016/j.neulet.2005.05.022
    • (2005) Neurosci. Lett , vol.385 , pp. 70-75
    • McDonald, H.Y.1    Wojtowicz, J.M.2
  • 41
    • 84875323105 scopus 로고    scopus 로고
    • Physiological role of peroxisome proliferator-activated receptors type alpha on dopamine systems
    • Melis, M., Carta, G., Pistis, M., and Banni, S. (2013). Physiological role of peroxisome proliferator-activated receptors type alpha on dopamine systems. CNS Neurol. Disord. Drug Targets 12, 70-77. doi: 10.2174/1871527311312010012
    • (2013) CNS Neurol. Disord. Drug Targets , vol.12 , pp. 70-77
    • Melis, M.1    Carta, G.2    Pistis, M.3    Banni, S.4
  • 42
    • 0037471433 scopus 로고    scopus 로고
    • Hippocampal cell genesis does not correlate with spatial learning ability in aged rats
    • Merrill, D. A., Karim, R., Darraq, M., Chiba, A. A., and Tuszynski, M. H. (2003). Hippocampal cell genesis does not correlate with spatial learning ability in aged rats. J. Comp. Neurol. 459, 201-207. doi: 10.1002/cne.10616
    • (2003) J. Comp. Neurol , vol.459 , pp. 201-207
    • Merrill, D.A.1    Karim, R.2    Darraq, M.3    Chiba, A.A.4    Tuszynski, M.H.5
  • 44
    • 84964363179 scopus 로고    scopus 로고
    • Epigenetic regulation of stemness maintenance in the neurogenic niches
    • Montalban-Loro, R., Domingo-Muelas, A., Bizy, A., and Ferron, S. R. (2015). Epigenetic regulation of stemness maintenance in the neurogenic niches. World J. Stem Cells 7, 700-710. doi: 10.4252/wjsc.v7.i4.700
    • (2015) World J. Stem Cells , vol.7 , pp. 700-710
    • Montalban-Loro, R.1    Domingo-Muelas, A.2    Bizy, A.3    Ferron, S.R.4
  • 45
    • 0345118108 scopus 로고    scopus 로고
    • Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS
    • Moreno, S., Farioli-Vecchioli, S., and Ceru, M. P. (2004). Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS. Neuroscience 123, 131-145. doi: 10.1016/j.neuroscience.2003.08.064
    • (2004) Neuroscience , vol.123 , pp. 131-145
    • Moreno, S.1    Farioli-Vecchioli, S.2    Ceru, M.P.3
  • 46
    • 84937954849 scopus 로고    scopus 로고
    • Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey
    • Ngwenya, L. B., Heyworth, N. C., Shwe, Y., Moore, T. L., and Rosene, D. L. (2015). Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey. Front. Syst. Neurosci. 9:102. doi: 10.3389/fnsys.2015.00102
    • (2015) Front. Syst. Neurosci , vol.9 , pp. 102
    • Ngwenya, L.B.1    Heyworth, N.C.2    Shwe, Y.3    Moore, T.L.4    Rosene, D.L.5
  • 47
    • 84865407887 scopus 로고    scopus 로고
    • Oxidative damage to RNA in aging and neurodegenerative disorders
    • Nunomura, A., Moreira, P. I., Castellani, R. J., Lee, H. G., Zhu, X., Smith, M. A., et al. (2012). Oxidative damage to RNA in aging and neurodegenerative disorders. Neurotoxicol. Res. 22, 231-248. doi: 10.1007/s12640-012-9331-x
    • (2012) Neurotoxicol. Res , vol.22 , pp. 231-248
    • Nunomura, A.1    Moreira, P.I.2    Castellani, R.J.3    Lee, H.G.4    Zhu, X.5    Smith, M.A.6
  • 48
    • 85027199765 scopus 로고    scopus 로고
    • Preventive effects of regular physical exercise against cognitive decline and the risk of dementia with age advancement
    • Paillard, T. (2015). Preventive effects of regular physical exercise against cognitive decline and the risk of dementia with age advancement. Sports Med. Open 1:4. doi: 10.1186/s40798-015-0016-x
    • (2015) Sports Med. Open , vol.1 , pp. 4
    • Paillard, T.1
  • 50
    • 20144365389 scopus 로고    scopus 로고
    • Estradiol and soy extract increase the production of new cells in the dentate gyrus of old rats
    • Pérez-Martín, M., Salazar, V., Castillo, C., Ariznavarreta, C., Azcoitia, I., Garcia-Segura, L. M., et al. (2005). Estradiol and soy extract increase the production of new cells in the dentate gyrus of old rats. Exp. Gerontol. 40, 450-453. doi: 10.1016/j.exger.2005.03.003
    • (2005) Exp. Gerontol , vol.40 , pp. 450-453
    • Pérez-Martín, M.1    Salazar, V.2    Castillo, C.3    Ariznavarreta, C.4    Azcoitia, I.5    Garcia-Segura, L.M.6
  • 51
    • 73449147663 scopus 로고    scopus 로고
    • Effects of the endogenous PPAR-alpha agonist, oleoylethanolamide on MDMA-induced cognitive deficits in mice
    • Plaza-Zabala, A., Berrendero, F., Suarez, J., Bermudez-Silva, F. J., Fernandez-Espejo, E., Serrano, A., et al. (2010). Effects of the endogenous PPAR-alpha agonist, oleoylethanolamide on MDMA-induced cognitive deficits in mice. Synapse 64, 379-389. doi: 10.1002/syn.20733
    • (2010) Synapse , vol.64 , pp. 379-389
    • Plaza-Zabala, A.1    Berrendero, F.2    Suarez, J.3    Bermudez-Silva, F.J.4    Fernandez-Espejo, E.5    Serrano, A.6
  • 52
    • 70349560028 scopus 로고    scopus 로고
    • The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation
    • Ramanan, S., Kooshki, M., Zhao, W., Hsu, F. C., Riddle, D. R., and Robbins, M. E. (2009). The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation. Int. J. Radiat. Oncol. Biol. Phys. 75, 870-877. doi: 10.1016/j.ijrobp.2009.06.059
    • (2009) Int. J. Radiat. Oncol. Biol. Phys , vol.75 , pp. 870-877
    • Ramanan, S.1    Kooshki, M.2    Zhao, W.3    Hsu, F.C.4    Riddle, D.R.5    Robbins, M.E.6
  • 53
    • 84896998313 scopus 로고    scopus 로고
    • Localization of peroxisome proliferator-activated receptor alpha (PPARalpha) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus
    • Rivera, P., Arrabal, S., Vargas, A., Blanco, E., Serrano, A., Pavon, F. J., et al. (2014). Localization of peroxisome proliferator-activated receptor alpha (PPARalpha) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus. Front. Neuroanat. 8:12. doi: 10.3389/fnana.2014.00012
    • (2014) Front. Neuroanat , vol.8 , pp. 12
    • Rivera, P.1    Arrabal, S.2    Vargas, A.3    Blanco, E.4    Serrano, A.5    Pavon, F.J.6
  • 54
    • 84939789111 scopus 로고    scopus 로고
    • Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context
    • Rivera, P., Bindila, L., Pastor, A., Perez-Martin, M., Pavon, F. J., Serrano, A., et al. (2015a). Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context. Front. Cell. Neurosci. 9:98. doi: 10.3389/fncel.2015.00098
    • (2015) Front. Cell. Neurosci , vol.9 , pp. 98
    • Rivera, P.1    Bindila, L.2    Pastor, A.3    Perez-Martin, M.4    Pavon, F.J.5    Serrano, A.6
  • 55
    • 84944446757 scopus 로고    scopus 로고
    • Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain
    • Rivera, P., Blanco, E., Bindila, L., Alen, F., Vargas, A., Rubio, L., et al. (2015b). Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain. Front. Cell. Neurosci. 9:379. doi: 10.3389/fncel.2015.00379
    • (2015) Front. Cell. Neurosci , vol.9 , pp. 379
    • Rivera, P.1    Blanco, E.2    Bindila, L.3    Alen, F.4    Vargas, A.5    Rubio, L.6
  • 56
    • 79955525578 scopus 로고    scopus 로고
    • Obesity-dependent cannabinoid modulation of proliferation in adult neurogenic regions
    • Rivera, P., Romero-Zerbo, Y., Pavon, F. J., Serrano, A., Lopez-Avalos, M. D., Cifuentes, M., et al. (2011). Obesity-dependent cannabinoid modulation of proliferation in adult neurogenic regions. Eur. J. Neurosci. 33, 1577-1586. doi: 10.1111/j.1460-9568.2011.07650.x
    • (2011) Eur. J. Neurosci , vol.33 , pp. 1577-1586
    • Rivera, P.1    Romero-Zerbo, Y.2    Pavon, F.J.3    Serrano, A.4    Lopez-Avalos, M.D.5    Cifuentes, M.6
  • 58
    • 84882865862 scopus 로고    scopus 로고
    • alpha-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors
    • Robins, S. C., Stewart, I., McNay, D. E., Taylor, V., Giachino, C., Goetz, M., et al. (2013). alpha-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors. Nat. Commun. 4:2049. doi: 10.1038/ncomms3049
    • (2013) Nat. Commun , vol.4 , pp. 2049
    • Robins, S.C.1    Stewart, I.2    McNay, D.E.3    Taylor, V.4    Giachino, C.5    Goetz, M.6
  • 59
    • 84883634043 scopus 로고    scopus 로고
    • The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons
    • Romano, A., Cassano, T., Tempesta, B., Cianci, S., Dipasquale, P., Coccurello, R., et al. (2013). The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons. Peptides 49, 21-26. doi: 10.1016/j.peptides.2013.08.006
    • (2013) Peptides , vol.49 , pp. 21-26
    • Romano, A.1    Cassano, T.2    Tempesta, B.3    Cianci, S.4    Dipasquale, P.5    Coccurello, R.6
  • 60
    • 0035851187 scopus 로고    scopus 로고
    • PPARgamma: a nuclear regulator of metabolism, differentiation, and cell growth
    • Rosen, E. D., and Spiegelman, B. M. (2001). PPARgamma: a nuclear regulator of metabolism, differentiation, and cell growth. J. Biol. Chem. 276, 37731-37734. doi: 10.1074/jbc. R100034200
    • (2001) J. Biol. Chem , vol.276 , pp. 37731-37734
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 61
    • 84938749022 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors bind to PPARalpha to upregulate neurotrophin expression in the brain and improve memory in mice
    • Roy, A., Jana, M., Kundu, M., Corbett, G. T., Rangaswamy, S. B., Mishra, R. K., et al. (2015). HMG-CoA reductase inhibitors bind to PPARalpha to upregulate neurotrophin expression in the brain and improve memory in mice. Cell Metab. 22, 253-265. doi: 10.1016/j.cmet.2015.05.022
    • (2015) Cell Metab , vol.22 , pp. 253-265
    • Roy, A.1    Jana, M.2    Kundu, M.3    Corbett, G.T.4    Rangaswamy, S.B.5    Mishra, R.K.6
  • 62
    • 84857983911 scopus 로고    scopus 로고
    • Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-alpha
    • Scuderi, C., Valenza, M., Stecca, C., Esposito, G., Carratu, M. R., and Steardo, L. (2012). Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-alpha. J. Neuroinflammation 9:49. doi: 10.1186/1742-2094-9-21
    • (2012) J. Neuroinflammation , vol.9 , pp. 49
    • Scuderi, C.1    Valenza, M.2    Stecca, C.3    Esposito, G.4    Carratu, M.R.5    Steardo, L.6
  • 63
    • 0038320030 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12, 14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability
    • Smith, S. A., Monteith, G. R., Holman, N. A., Robinson, J. A., May, F. J., and Roberts-Thomson, S. J. (2003). Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12, 14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability. J. Neurosci. Res. 72, 747-755. doi: 10.1002/jnr.10613
    • (2003) J. Neurosci. Res , vol.72 , pp. 747-755
    • Smith, S.A.1    Monteith, G.R.2    Holman, N.A.3    Robinson, J.A.4    May, F.J.5    Roberts-Thomson, S.J.6
  • 64
    • 33745001464 scopus 로고    scopus 로고
    • Persistent production of neurons from adult brain stem cells during recovery after stroke
    • Thored, P., Arvidsson, A., Cacci, E., Ahlenius, H., Kallur, T., Darsalia, V., et al. (2006). Persistent production of neurons from adult brain stem cells during recovery after stroke. Stem Cells 24, 739-747. doi: 10.1634/stemcells.2005-0281
    • (2006) Stem Cells , vol.24 , pp. 739-747
    • Thored, P.1    Arvidsson, A.2    Cacci, E.3    Ahlenius, H.4    Kallur, T.5    Darsalia, V.6
  • 65
    • 25444533023 scopus 로고    scopus 로고
    • Exercise enhances learning and hippocampal neurogenesis in aged mice
    • Van Praag, H., Shubert, T., Zhao, C., and Gage, F. H. (2005). Exercise enhances learning and hippocampal neurogenesis in aged mice. J. Neurosci. 25, 8680-8685. doi: 10.1523/JNEUROSCI.1731-05.2005
    • (2005) J. Neurosci , vol.25 , pp. 8680-8685
    • Van Praag, H.1    Shubert, T.2    Zhao, C.3    Gage, F.H.4
  • 66
    • 84939943395 scopus 로고    scopus 로고
    • Chronic oleoylethanolamide treatment improves spatial cognitive deficits through enhancing hippocampal neurogenesis after transient focal cerebral ischemia
    • Yang, L. C., Guo, H., Zhou, H., Suo, D. Q., Li, W. J., Zhou, Y., et al. (2015). Chronic oleoylethanolamide treatment improves spatial cognitive deficits through enhancing hippocampal neurogenesis after transient focal cerebral ischemia. Biochem. Pharmacol. 94, 270-281. doi: 10.1016/j.bcp.2015.02.012
    • (2015) Biochem. Pharmacol , vol.94 , pp. 270-281
    • Yang, L.C.1    Guo, H.2    Zhou, H.3    Suo, D.Q.4    Li, W.J.5    Zhou, Y.6
  • 67
    • 84937714545 scopus 로고    scopus 로고
    • Environmental Enrichment Attenuated Sevoflurane-Induced Neurotoxicity through the PPAR-gamma Signaling Pathway
    • Zhao, Y., Chen, K., and Shen, X. (2015). Environmental Enrichment Attenuated Sevoflurane-Induced Neurotoxicity through the PPAR-gamma Signaling Pathway. Biomed Res. Int. 2015:107149. doi: 10.1155/2015/107149
    • (2015) Biomed Res. Int , vol.2015
    • Zhao, Y.1    Chen, K.2    Shen, X.3
  • 68
    • 0031691204 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids
    • Zhou, Y. C., and Waxman, D. J. (1998). Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids. Environ. Health Perspect. 106(Suppl. 4), 983-988
    • (1998) Environ. Health Perspect , vol.106 , pp. 983-988
    • Zhou, Y.C.1    Waxman, D.J.2
  • 69
    • 84877654967 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) gamma and PPARalpha agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders?
    • Zolezzi, J. M., Silva-Alvarez, C., Ordenes, D., Godoy, J. A., Carvajal, F. J., Santos, M. J., et al. (2013). Peroxisome proliferator-activated receptor (PPAR) gamma and PPARalpha agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders? PLoS ONE 8:e64019. doi: 10.1371/journal.pone.0064019
    • (2013) PLoS ONE , vol.8
    • Zolezzi, J.M.1    Silva-Alvarez, C.2    Ordenes, D.3    Godoy, J.A.4    Carvajal, F.J.5    Santos, M.J.6


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