Effect of reduced maternal protein intake in pregnancy in the rat on the fatty acid composition of brain, liver, plasma, heart and lung phospholipids of the offspring after weaning

British Journal of Nutrition

Volumn 90, Issue 2, 2003, Pages 345-352

  Burdge, Graham C ^a   Delange, Emmanuelle ^a   Dubois, Ludivine ^a   Dunn, Rebecca L ^a   Hanson, Mark A ^a   Jackson, Alan A ^a   Calder, Philip C ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Low protein diet; Phospholipids; Polyunsaturated fatty acids; Rats

Indexed keywords

ARACHIDONIC ACID; DIACYLGLYCEROL; DOCOSAHEXAENOIC ACID; FATTY ACID; LIPID; MONOUNSATURATED FATTY ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPASE; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CELL MEMBRANE; DELIVERY; DIETARY INTAKE; ENZYME ACTIVITY; FATTY ACID ANALYSIS; FEEDING; FEMALE; FETUS; FETUS DEVELOPMENT; FOOD COMPOSITION; HEART; LIVER; LUNG; MALE; MATERNAL NUTRITION; MATING; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PLASMA; PREGNANCY; PROGENY; RAT; SIGNAL TRANSDUCTION; TISSUE; WEANING;

ANIMALS; BRAIN; CELL MEMBRANE; DIETARY PROTEINS; FATTY ACIDS; FATTY ACIDS, MONOUNSATURATED; FATTY ACIDS, UNSATURATED; FEMALE; LINOLEIC ACID; LIVER; LUNG; MYOCARDIUM; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHOLIPIDS; PREGNANCY; RATS; RATS, WISTAR; WEANING;

ANIMALIA;

EID: 0042563136     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN2003909     Document Type: Article

References (44)

1. Bourre JM, Francois M, Youyou A, et al. (1989) The effects of dietary alpha-linolenic acid on the comparison of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. J Nutr 119, 1880-1892.
2. Burdge GC, Dunn RL, Wootton SA & Jackson AA (2002) Effect of reduced dietary protein intake on hepatic and plasma essential fatty acid concentrations in the adult female rat: Effect of pregnancy and consequences for accumulation of arachidonic and docosahexaeonic acids in fetal liver and brain. Br J Nutr 88, 379-387.
3. Burdge GC, Hunt AN & Postle AD (1994) Mechanisms of hepatic phosphatidylcholine synthesis in adult rat: Effects of pregnancy. Biochem J 303, 941-947.
4. Burdge GC, Kelly FJ & Postle A (1993a) Mechanisms of hepatic phosphatidylcholine synthesis in the developing guinea pig: Contributions of acyl remodelling and of N-methylation of phosphatidylethanolamine. Biochem J 290, 67-73.
5. Burdge GC, Kelly FJ & Postle AD (1993b) Synthesis of phosphatidylcholine in guinea-pig fetal lung involves acyl remodelling and differential turnover of individual molecular species. Biochim Biophys Acta 1166, 251-257.
6. Burdge GC & Postle AD (1995) Phospholipid molecular species composition of developing fetal guinea pig brain. Lipids 30, 719-724.
7. Burdge GC, Wright P, Jones AE & Wootton SA (2000) A method for separation of phosphatidylcholine, triacylglycerol, non-esterified fatty acids and cholesterol esters from plasma by solid phase extraction. Br J Nutr 84, 781-787.
8. Calder PC (2001) Polyunsaturated fatty acids, inflammation and immunity. Lipids 36, 1007-1024.
9. Connor WE & Neuringer M (1988) The effects of n-3 fatty acid deficiency and repletion upon fatty acid composition and function of the brain and retina. Prog Clin Biol Res 282, 275-294.
10. Connor WE, Neuringer M & Lin DS (1990) Dietary effects on brain fatty acid composition: The reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes and plasma of rhesus monkeys. J Lipid Res 31, 237-247.
11. De Thomas ME, Mercuri O & Serres C (1983) Effect of cross-fostering rats at birth on the normal supply of essential fatty acids during protein deficiency. J Nutr 113, 314-319.
12. Folch J, Lees M & Sloane-Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226, 497-509.
13. Heung YM & Postle AD (1995) The molecular selectivity of phospholipase D in HL60 granulocytes. FEBS Lett 364, 250-254.
14. Innis SM (1991) Essential fatty acids in growth and development. Prog Lipid Res 30, 39-103.
15. Jackson AA, Phillips G, McClelland I & Jahoor F (2001) Synthesis of hepatic secretary proteins in normal adults consuming a diet marginally adequate in protein. Am J Physiol 281, G1179-G1187.
16. Kishimoto Y, Davies WE & Radin NS (1965) Developing rat brain: Changes in cholesterol, galactolipids, and the individual fatty acids of gangliosides and glycerophosphotidates. J Lipid Res 6, 532-536.
17. Koletzko B & Braun M (1991) Arachidonic acid and early human growth: Is there a relation? Ann Nutr Metab 35, 128-131.
18. Langley SC & Jackson AA (1994) Increased systolic blood pressure in adult rats induced by foetal exposure to maternal low protein diet. Clin Sci 86, 217-222.
19. Langley-Evans SC & Nwagwu M (1998) Impaired growth and increased glucocorticoid-sensitive enzyme activities in tissues for rat fetuses exposed to maternal low protein diets. Life Sci 63, 605-615.
20. Langley-Evans SC, Whelham SJ, Sherman RC & Jackson AA (1996) Weanling rats exposed to maternal low-protein diets during discrete periods of gestation exhibit differing severity of hypertension. Clin Sci 91, 607-615.
21. Leaf AA, Leighfield MJ, Costeloe KL & Crawford MA (1992) Long chain polyunsaturated fatty acids and fetal growth. Early Hum Dev 30, 183-191.
22. Leat WMF, Curtis R, Millicham NJ & Cox RW (1986) Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. Ann Nutr Metab 30, 166-174.
23. Lin DS, Connor WE, Anderson GJ & Neuringer M (1990) Effects of dietary n-3 fatty acids on the phospholipid molecular species of monkey brain. J Neurochem, 55, 1200-1207.
24. Litman BJ & Mitchell DC (1996) A role for phospholipid polyunsaturation in modulating membrane protein function. Lipids 31, Suppl., S193-S197.
25. Mitchell DC, Straume M & Litman BJ (1992) Role of sn-1 saturated, sn-2 polyunsaturated phospholipids in control of membrane receptor conformational equilibrium: Effects of cholesterol and acyl chain unsaturation on the metarhodopsin Iφ metarhodopsin II equilibrium. Biochemistry 31, 662-670.
26. Neuringer M, Anderson GJ & Connor WE (1988) The essentiality of n-3 fatty acids for the development and function of the retina and brain. Annu Rev Nutr 8, 517-541.
27. Neuringer M, Connor WE, Lin DS, Barstad L & Luck S (1986) Biochemical and functional effects of prenatal and postnatal omega-3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc Natl Acad Sci USA 83, 4021-4025.
28. Neuringer M, Connor WE, Van Petten C & Barstad L (1984) Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. J Clin Invest 73, 272-276.
29. Ozanne SE, Martinsz ND, Petry CJ, Loizou CL & Hales CN (1998) Maternal low protein diet in rats programmes fatty acids desaturase activities in the offspring. Diabetologica 41, 1337-1342.
30. Pawlosky RJ, Denkins Y, Ward G & Salem N (1997) Retinal and brain accretion of long-chain polyunsaturated fatty acids in developing felines: The effects of corn oil-based maternal diets. Am J Nutr 65, 465-472.
31. Peluffo RO & Brenner RR (1974) Influence of dietary protein on 6- and 9- desaturation of fatty acids in rats of different ages and in different seasons. J Nutr 104, 894-900.
32. Reeves PG, Nielsen FH & Fahey GC (1993) AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet. J Nutr 123, 1939-1951.
33. Reisbick S, Neuringer M, Hasnain R & Connor WE (1990) Polydipsia in rhesus monkeys deficient in omega-3 fatty acids. Physiol Behav 47, 315-323.
34. Reisbick S, Neuringer M, Hasnain R & Connor WE (1994) Home cage behavior of rhesus monkeys with long-term deficiency of omega-3 fatty acids. Physiol Behav 55, 231-239.
35. Ristic V, Petrovic G & Ristic M (1985) Effect of a low protein diet on the serum and liver lipid content of rats. Acta Med Iugosl 39, 117-123.
36. Salem N Jr. & Niebylski CD (1995) The nervous system has an absolute molecular species requirement for proper function. Mol Membr Biol 12, 131-134.
37. Sanchez-Pinera P, Micol V, Corbalan-Garcia S & Gomez-Fernandez JC (1999) A comprehensive study of the activation of protein kinase C alpha by different diacylglycerol isomers. Biochem J 337, 387-395.
38. Sinclair AJ & Crawford MA (1972) The accumulation of arachidonate and docosahexaenoate in the developing rat brain. J Neurochem 19, 1753-1758.
39. Smit EN, Dijkstra JM, Schnater TA, Seerat E, Muskiet FAJ & Boersma ER (1997) Effects of malnutrition on the erythrocyte fatty acid composition and plasma vitamin E levels of Pakistani children. Acta Paediatrica 86, 690-695.
40. Smit EN, Woltil HA, Boersma ER & Muskiet FAJ (1999) Low erythrocyte docosahexaenoic acid in malnourised, often breast-fed, Pakistani infants. A matter of concern? Eur J Pediatr 158, 525.
41. Sprecher H (2000) Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochim Biophys Acta 1486, 219-231.
42. Su HM, Keswick LA & Brenna JT (1996) Increasing dietary linolenic acid in young rats increases and then decreases docosahexaenoic acid in retina but not brain. Lipids 31, 1289-1298.
43. Tijburg LB, Samborski RW & Vance DE (1991) Evidence that remodeling of the fatty acids of phosphatidylcholine is regulated in isolated rat hepatocytes and involves both the sn-1 and sn-2 positions. Biochim Biophys Acta 1085, 184-190.
44. Weisinger HS, Armitage JA, Sinclair AJ, Vingrys AJ, Burns PL & Weisinger RS (2001) Perinatal omega-3 fatty acid deficiency affects blood pressure later in life. Nat Med 7, 258-259.