"A randomized, double-blind study of the effects of omega-3 fatty acids (Omegaven™) on outcome after major liver resection"

BMC Gastroenterology

Volumn 15, Issue 1, 2015, Pages

  Linecker, Michael ^a   Limani, Perparim ^a   Botea, Florin ^b   Popescu, Irinel ^b   Alikhanov, Ruslan ^c   Efanov, Michail ^c   Kim, Pavel ^c   Khatkov, Igor ^c   Raptis, Dimitri Aristotele ^a   Tschuor, Christoph ^a   Beck Schimmer, Beatrice ^a   Bonvini, John ^a   Wirsching, Andrea ^a   Kron, Philipp ^a   Slankamenac, Ksenija ^a   Humar, Bostjan ^a   Graf, Rolf ^a   Petrowsky, Henrik ^a   Clavien, Pierre Alain ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b FUNDENI CLINICAL INSTITUTE   (Romania)

^c Central Research Institute of Gastroenterology   (Russian Federation)

Author keywords

Clavien Dindo complication score; Comprehensive Complication Index (CCI); Major liver surgery; Omega3 polyunsaturated fatty acids (n3 PUFA); Omegaven

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FATTY ACID; ICOSANOID; OMEGAVEN; PLACEBO; FISH OIL; OMEGA 3 FATTY ACID;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEASIBILITY STUDY; FEMALE; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; HUMAN TISSUE; INTENSIVE CARE UNIT; LIVER FUNCTION TEST; LIVER INJURY; LIVER PROTECTION; LIVER RESECTION; MAJOR CLINICAL STUDY; MORBIDITY; MORTALITY; MULTICENTER STUDY; PATIENT COMPLIANCE; PHASE 3 CLINICAL TRIAL; POSTOPERATIVE PERIOD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TREATMENT OUTCOME; ADVERSE EFFECTS; BLOOD; CLINICAL TRIAL; ISCHEMIC PRECONDITIONING; LENGTH OF STAY; METABOLISM; METHODOLOGY; PROCEDURES; REPERFUSION INJURY;

ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; DOUBLE-BLIND METHOD; EICOSANOIDS; FATTY ACIDS; FATTY ACIDS, OMEGA-3; FISH OILS; HEPATECTOMY; HUMANS; INTENSIVE CARE UNITS; ISCHEMIC PRECONDITIONING; LENGTH OF STAY; LIVER FUNCTION TESTS; PROSPECTIVE STUDIES; REPERFUSION INJURY; RESEARCH DESIGN;

EID: 84939173471     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/s12876-015-0331-1     Document Type: Article

References (11)

1. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205-13.
2. Slankamenac K, Graf R, Barkun J, Puhan MA, Clavien PA. The comprehensive complication index: a novel continuous scale to measure surgical morbidity. Ann Surg. 2013;258(1):1-7.
3. Burr GO, Burr MM. Nutrition classics from The Journal of Biological Chemistry 82:345-67, 1929. A new deficiency disease produced by the rigid exclusion of fat from the diet. Nutr Rev. 1973;31(8):248-9.
4. Dyerberg J, Bang HO, Stoffersen E, Moncada S, Vane JR. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet. 1978;2(8081):117-9.
5. El-Badry AM, Moritz W, Contaldo C, Tian Y, Graf R, Clavien PA. Prevention of reperfusion injury and microcirculatory failure in macrosteatotic mouse liver by omega-3 fatty acids. Hepatology. 2007;45(4):855-63.
6. Marsman HA, de Graaf W, Heger M, van Golen RF, Ten Kate FJ, Bennink R, et al. Hepatic regeneration and functional recovery following partial liver resection in an experimental model of hepatic steatosis treated with omega-3 fatty acids. Br J Surg. 2013;100(5):674-83.
7. Raptis DA, Limani P, Jang JH, Ungethüm U, Tschuor C, Graf R, et al. GPR120 on Kupffer cells mediates hepatoprotective effects of omega3-fatty acids. J Hepatol. 2014;60(3):625-32.
8. El-Badry AM, Jang JH, Elsherbiny A, Contaldo C, Tian Y, Raptis DA, et al. Chemical composition of hepatic lipids mediates reperfusion injury of the macrosteatotic mouse liver through thromboxane A(2). J Hepatol. 2011;55(6):1291-9.
9. Clavien PA, Oberkofler CE, Raptis DA, Lehmann K, Rickenbacher A, El-Badry AM. What is critical for liver surgery and partial liver transplantation: size or quality? Hepatology. 2010;52(2):715-29.
10. Schuchardt JP, Schneider I, Willenberg I, Yang J, Hammock BD, Hahn A, et al. Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA. Prostaglandins Other Lipid Mediat. 2014;109-111:23-31.
11. Schulz KF, Altman DG, Moher D, CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c332.