Lipid metabolites as metabolic messengers in inter-organ communication

Trends in Endocrinology and Metabolism

Volumn 25, Issue 7, 2014, Pages 356-363

  Liu, Sihao ^a,b   Alexander, Ryan K ^a   Lee, Chih Hao ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

BAIBA; Lipid metabolites; Lipogenesis; Metabolic flexibility; PPARs; Tregs

Indexed keywords

4 AMINOBUTYRIC ACID; ICOSANOID; LIPID; SHORT CHAIN FATTY ACID; SPHINGOLIPID; GLUCOSE;

ADIPOSE TISSUE; DIET; ENERGY METABOLISM; HUMAN; IMMUNOCOMPETENT CELL; INTERORGAN COMMUNICATION; INTESTINE; LIPID METABOLISM; LIPOGENESIS; LIVER; MEDIATOR; METABOLIC REGULATION; METABOLITE; METABOLOMICS; MOLECULAR INTERACTION; MUSCLE TISSUE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; METABOLISM; PHYSIOLOGY; REGULATORY T LYMPHOCYTE;

ANIMALS; ENERGY METABOLISM; GLUCOSE; HUMANS; LIPID METABOLISM; T-LYMPHOCYTES, REGULATORY;

EID: 84903483525     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2014.05.002     Document Type: Review

References (71)

1. Vernochet C., Kahn C.R. Mitochondria, obesity and aging. Aging 2012, 4:859-860.
2. Gregor M.F., Hotamisligil G.S. Inflammatory mechanisms in obesity. Annu. Rev. Immunol. 2011, 29:415-445.
3. Samuel V.T., Shulman G.I. Mechanisms for insulin resistance: common threads and missing links. Cell 2012, 148:852-871.
4. Glass C.K., Olefsky J.M. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab. 2012, 15:635-645.
5. Galgani J.E., et al. Metabolic flexibility and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 2008, 295:E1009-E1017.
6. Nussey S., Whitehead S. Endocrinology: An Integrated Approach 2001, BIOS Scientific Publishers.
7. Bruss M.D., et al. Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates. Am. J. Physiol. Endocrinol. Metab. 2010, 298:E108-E116.
8. Pedersen B.K., Febbraio M.A. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat. Rev. Endocrinol. 2012, 8:457-465.
9. Randle P.J., et al. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963, 1:785-789.
10. Parks E.J., Hellerstein M.K. Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms. Am. J. Clin. Nutr. 2000, 71:412-433.
11. Abu-Elheiga L., et al. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:12011-12016.
12. Chirala S.S., et al. Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:6358-6363.
13. Brown M.S., Goldstein J.L. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab. 2008, 7:95-96.
14. Sun Z., Lazar M.A. Dissociating fatty liver and diabetes. Trends Endocrinol. Metab. 2013, 24:4-12.
15. Ahmadian M., et al. PPARgamma signaling and metabolism: the good, the bad and the future. Nat. Med. 2013, 19:557-566.
16. Herman M.A., et al. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature 2012, 484:333-338.
17. Abel E.D., et al. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 2001, 409:729-733.
18. Maeda K., et al. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. 2005, 1:107-119.
19. Wu C., et al. Enhancing hepatic glycolysis reduces obesity: differential effects on lipogenesis depend on site of glycolytic modulation. Cell Metab. 2005, 2:131-140.
20. Miyazaki M., et al. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab. 2007, 6:484-496.
21. Cao H., et al. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 2008, 134:933-944.
22. Chakravarthy M.V., et al. 'New' hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab. 2005, 1:309-322.
23. Chakravarthy M.V., et al. Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell 2009, 138:476-488.
24. Liu S., et al. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature 2013, 502:550-554.
25. Liu S., et al. Role of peroxisome proliferator-activated receptor δ/β in hepatic metabolic regulation. J. Biol. Chem. 2011, 286:1237-1247.
26. Cao H. Adipocytokines in obesity and metabolic disease. J. Endocrinol. 2014, 220:T47-T59.
27. Jacobi D., et al. Adipose tissue signaling by nuclear receptors in metabolic complications of obesity. Adipocyte 2012, 1:4-12.
28. Holzer R.G., et al. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 2011, 147:173-184.
29. Harizi H., et al. Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology. Trends Mol. Med. 2008, 14:461-469.
30. Ricciotti E., FitzGerald G.A. Prostaglandins and inflammation. Arterioscler. Thromb. Vasc. Biol. 2011, 31:986-1000.
31. Okunishi K., Peters-Golden M. Leukotrienes and airway inflammation. Biochim. Biophys. Acta 2011, 1810:1096-1102.
32. Sadik C.D., Luster A.D. Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation. J. Leukoc. Biol. 2012, 91:207-215.
33. Levy B.D., et al. Lipid mediator class switching during acute inflammation: signals in resolution. Nat. Immunol. 2001, 2:612-619.
34. Schwab J.M., Serhan C.N. Lipoxins and new lipid mediators in the resolution of inflammation. Curr. Opin. Pharmacol. 2006, 6:414-420.
35. Claria J., et al. Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat. J. Immunol. 2012, 189:2597-2605.
36. Medzhitov R. Origin and physiological roles of inflammation. Nature 2008, 454:428-435.
37. Roberts L.D., et al. Beta-aminoisobutyric acid induces browning of white fat and hepatic beta-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 2014, 19:96-108.
38. Coll A.P., et al. The hormonal control of food intake. Cell 2007, 129:251-262.
39. Cota D., et al. Hypothalamic mTOR signaling regulates food intake. Science 2006, 312:927-930.
40. Wolfgang M.J., et al. Regulation of hypothalamic malonyl-CoA by central glucose and leptin. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:19285-19290.
41. Fu J., et al. Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. J. Biol. Chem. 2007, 282:1518-1528.
42. Schwartz G.J., et al. The lipid messenger OEA links dietary fat intake to satiety. Cell Metab. 2008, 8:281-288.
43. Fu J., et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 2003, 425:90-93.
44. Gaetani S., et al. The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin. J. Neurosci. 2010, 30:8096-8101.
45. Gillum M.P., et al. N-acylphosphatidylethanolamine, a gut-derived circulating factor induced by fat ingestion, inhibits food intake. Cell 2008, 135:813-824.
46. Morris S., et al. Characterization of fatty acid clearance in premature neonates during intralipid infusion. Pediatr. Res. 1998, 43:245-249.
47. Ridaura V.K., et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 2013, 341:1241214.
48. Koeth R.A., et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat. Med. 2013, 19:576-585.
49. Parks B.W., et al. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab. 2013, 17:141-152.
50. Henao-Mejia J., et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012, 482:179-185.
51. Smith P.M., et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 2013, 341:569-573.
52. Iida N., et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science 2013, 342:967-970.
53. Viaud S., et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 2013, 342:971-976.
54. Mukherji A., et al. Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs. Cell 2013, 153:812-827.
55. An D., et al. Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell 2014, 156:123-133.
56. Arpaia N., et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 2013, 504:451-455.
57. Furusawa Y., et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 2013, 504:446-450.
58. Cipolletta D., et al. PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 2012, 486:549-553.
59. Ji Y., et al. Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity. J. Biol. Chem. 2012, 287:13561-13571.
60. Osborn O., Olefsky J.M. The cellular and signaling networks linking the immune system and metabolism in disease. Nat. Med. 2012, 18:363-374.
61. Kennedy E.P., Weiss S.B. The function of cytidine coenzymes in the biosynthesis of phospholipides. J. Biol. Chem. 1956, 222:193-214.
62. Wright M.M., McMaster C.R. PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1). Lipids 2002, 37:663-672.
63. Lands W.E. Metabolism of glycerolipids. 2. The enzymatic acylation of lysolecithin. J. Biol. Chem. 1960, 235:2233-2237.
64. Zhao Y., et al. Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. 2008, 283:8258-8265.
65. Kind T., et al. LipidBlast in silico tandem mass spectrometry database for lipid identification. Nat. Methods 2013, 10:755-758.
66. Brown M., et al. Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets. Bioinformatics 2011, 27:1108-1112.
67. 13CMS: global tracking of isotopic labels in untargeted metabolomics. Anal. Chem. 2014, 86:1632-1639.
68. Xia J., et al. MetaboAnalyst 2.0 - a comprehensive server for metabolomic data analysis. Nucleic Acids Res. 2012, 40:W127-W133.
69. Bostrom P., et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012, 481:463-468.
70. Yi P., et al. Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell 2013, 153:747-758.
71. Lee C.H., et al. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology 2003, 144:2201-2207.