Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 42, 2016, Pages E6506-E6515

  Villar Piqué, Anna ^a   Da Fonseca, Tomás Lopes ^a   Sant'Anna, Ricardo ^b,c,d   Szegö, Éva Mónika ^a   Fonseca Ornelas, Luis ^e   Pinho, Raquel ^a   Carija, Anita ^c   Gerhardt, Ellen ^a   Masaracchia, Caterina ^a   Gonzalez, Enrique Abad ^e,f   Rossetti, Giulia ^e,g   Carloni, Paolo ^e   Fernández, Claudio O ^h,i   Foguel, Debora ^b   Milosevic, Ira ^j   Zweckstetter, Markus ^a,e,k   Ventura, Salvador ^c,d   Outeiro, Tiago Fleming ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^e FORSCHUNGSZENTRUM JÜLICH   (Germany)

^f RWTH AACHEN UNIVERSITY   (Germany)

^g Universidad Nacional de Rosario   (Argentina)

^h UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

ⁱ EUROPEAN NEUROSCIENCE INSTITUTE   (Germany)

^j GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^k MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

more..

Author keywords

Copper; H50Q mutation; Inclusions; Protein aggregation; synuclein

Indexed keywords

ALPHA SYNUCLEIN; COPPER ION; GLIAL FIBRILLARY ACIDIC PROTEIN; HEAT SHOCK PROTEIN 90; MICROTUBULE ASSOCIATED PROTEIN 2; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPSIN; SYNAPTOPHYSIN; TAU PROTEIN; COPPER; HISTIDINE; PROTEIN AGGREGATE;

ARTICLE; ASTROCYTE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CELL LOSS; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENVIRONMENTAL FACTOR; HEREDITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECONDARY STRUCTURE; ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL; CELL CULTURE; CELL INCLUSION; CHEMISTRY; ENVIRONMENT; GENETIC PREDISPOSITION; GENETICS; KINETICS; METABOLISM; MUTATION; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; PROTEINOSIS; RAT;

ALPHA-SYNUCLEIN; AMINO ACID SUBSTITUTION; ANIMALS; CELLS, CULTURED; COPPER; ENVIRONMENT; GENETIC PREDISPOSITION TO DISEASE; HISTIDINE; HUMANS; INCLUSION BODIES; KINETICS; MUTATION; NEURONS; PHOSPHORYLATION; PROTEIN AGGREGATES; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN CONFORMATION, ALPHA-HELICAL; RATS;

EID: 84991593758     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1606791113     Document Type: Article

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