Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity

Molecular Neurodegeneration

Volumn 10, Issue 1, 2015, Pages

  Xiang, Wei ^a   Menges, Stefanie ^b   Schlachetzki, Johannes C M ^b   Meixner, Holger ^b   Hoffmann, Anna Carin ^a   Schlötzer Schrehardt, Ursula ^b   Becker, Cord Michael ^a   Winkler, Jürgen ^b   Klucken, Jochen ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

4 hydroxy 2 nonenal; Alpha synuclein; H50Q mutation; Histidine 50; Parkinson's disease; Posttranslational modification

Indexed keywords

4 HYDROXYNONENAL; ALPHA SYNUCLEIN; HISTIDINE; HYDROGEN PEROXIDE; PROTEIN AGGREGATE;

ARTICLE; CELL DAMAGE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MUTATION; OLIGOMERIZATION; PARKINSON DISEASE; PATHOGENESIS; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; CELL CULTURE; CYTOLOGY; GENETICS; METABOLISM; NERVE CELL; PHYSIOLOGY;

ALPHA-SYNUCLEIN; CELL DEATH; CELLS, CULTURED; HISTIDINE; HUMANS; MUTATION; NEURONS; PARKINSON DISEASE; PROTEIN AGGREGATES; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84961506813     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-015-0004-0     Document Type: Article

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