The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity

Human Molecular Genetics

Volumn 23, Issue 25, 2014, Pages 6732-6745

  Chutna, Oldriska ^a   Gonçalves, Susana ^a   Villar Piqué, Anna ^b   Guerreiro, Patrícia ^a,b   Marijanovic, Zrinka ^a   Mendes, Tiago ^a   Ramalho, José ^c   Emmanouilidou, Evangelia ^d   Ventura, Salvador ^e   Klucken, Jochen ^f   Barral, Duarte C ^c   Giorgini, Flaviano ^g   Vekrellis, Kostas ^d   Outeiro, Tiago F ^a,b,h  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^c NOVA MEDICAL SCHOOL   (Portugal)

^d BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^f UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^g UNIVERSITY OF LEICESTER   (United Kingdom)

^h INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; HYBRID PROTEIN; PROTEIN AGGREGATE; PROTEIN BINDING; RAB PROTEIN; RAB11 PROTEIN; SMALL INTERFERING RNA;

ANTAGONISTS AND INHIBITORS; CELL INCLUSION; CHEMISTRY; CYTOLOGY; EXOSOME; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; NERVE CELL; PLASMID; SECRETION (PROCESS); SIGNAL TRANSDUCTION; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ALPHA-SYNUCLEIN; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; EXOSOMES; GENE EXPRESSION REGULATION; HUMANS; INCLUSION BODIES; NEURONS; PLASMIDS; PROTEIN AGGREGATES; PROTEIN BINDING; RAB GTP-BINDING PROTEINS; RECOMBINANT FUSION PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 85005916286     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu391     Document Type: Article

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