Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner

Cell Metabolism

Volumn 24, Issue 2, 2016, Pages 295-310

  Kawano, Yoshinaga ^a   Nakae, Jun ^a   Watanabe, Nobuyuki ^b   Kikuchi, Tetsuhiro ^a   Tateya, Sanshiro ^c   Tamori, Yoshikazu ^c,d   Kaneko, Mari ^e   Abe, Takaya ^e   Onodera, Masafumi ^b   Itoh, Hiroshi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^c KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d Department of Internal Medicine   (Japan)

^e RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CCR2; INFLAMMASOME; INTESTINAL EPITHELIAL CELL SPECIFIC TAMOXIFEN INDUCIBLE CCL2; UNCLASSIFIED DRUG; INSULIN; MONOCYTE CHEMOTACTIC PROTEIN 1;

ADIPOSE TISSUE; ANIMAL CELL; ARTICLE; BODY WEIGHT; CHRONIC INFLAMMATION; COLON; CONTROLLED STUDY; GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; LIPID DIET; MACROPHAGE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; DRUG EFFECTS; EPITHELIUM CELL; GENE DELETION; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PERMEABILITY;

ADIPOSE TISSUE; ANIMALS; CHEMOKINE CCL2; COLON; DIET, HIGH-FAT; EPITHELIAL CELLS; GASTROINTESTINAL MICROBIOME; GENE DELETION; INFLAMMASOMES; INFLAMMATION; INSULIN; INSULIN RESISTANCE; MACROPHAGES; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SPECIFICITY; PERMEABILITY; RECEPTORS, CCR2;

EID: 84991048144     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.07.009     Document Type: Article

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