Impact of diet-induced obesity on intestinal stem cells: Hyperproliferation but impaired intrinsic function that requires insulin/IGF1

Endocrinology (United States)

Volumn 155, Issue 9, 2014, Pages 3302-3314

  Mah, Amanda T ^a   Landeghem, Laurianne Van ^b   Gavin, Hannah E ^c   Magness, Scott T ^b   Lund, P Kay ^b  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c The University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOGRANIN A; CYCLIN D1; EDOXUDINE; GLUCOSE; HORMONE; INSULIN; MATRIGEL; SOMATOMEDIN C; TRANSCRIPTION FACTOR SOX9;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL COUNT; CELL CYCLE S PHASE; CELL EXPANSION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DIET INDUCED OBESITY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GOBLET CELL; HISTOPATHOLOGY; HORMONE BLOOD LEVEL; HYPERINSULINEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INTESTINAL STEM CELL; INTESTINE EPITHELIUM CELL; LIPID DIET; MALE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; ANIMAL; CYTOLOGY; GENETICS; HUMAN; INTESTINE; METABOLISM; MOUSE; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; STEM CELL; TRANSGENIC MOUSE;

ANIMALS; CELL PROLIFERATION; DIET, HIGH-FAT; FEMALE; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; INTESTINES; MALE; MICE; MICE, TRANSGENIC; OBESITY; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 84907060528     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-1112     Document Type: Article

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