Characterization of hepatotoxicity mechanisms triggered by designer cathinone drugs (β-keto amphetamines)

Toxicological Sciences

Volumn 153, Issue 1, 2016, Pages 89-102

  Valente, Maria João ^a   Araújo, Ana Margarida ^a   Bastos, Maria de Lourdes ^a   Fernandes, Eduarda ^a   Carvalho, Félix ^a   Guedes de Pinho, Paula ^a   Carvalho, Márcia ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b CEBIMED   (Portugal)

Author keywords

Apoptosis; Hepatotoxicity; Oxidative stress; Synthetic cathinones; keto amphetamines

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 3,4 METHYLENEDIOXYPROVALERONE; 4 METHYLETHCATHINONE; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; AMPHETAMINE DERIVATIVE; ASCORBIC ACID; BETA KETO AMPHETAMINE DERIVATIVE; CASPASE; CASPASE INHIBITOR; CATHINONE; DESIGNER DRUG; GLUTATHIONE; GLUTATHIONE DISULFIDE; METHYLONE; PENTEDRONE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ALKALOID; ANTIOXIDANT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; IN VITRO STUDY; LIVER CELL; LIVER TOXICITY; MALE; MITOCHONDRION; MOLECULAR BIOLOGY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN EXPRESSION; RAT; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; DRUG EFFECTS; LIVER; WISTAR RAT;

ALKALOIDS; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELLS, CULTURED; DESIGNER DRUGS; LIVER; MALE; MODELS, BIOLOGICAL; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 84991030801     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw105     Document Type: Article

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