Detection of new psychoactive substance use among emergency room patients: Results from the Swedish STRIDA project

Forensic Science International

Volumn 243, Issue , 2014, Pages 23-29

  Helander, Anders ^a   Bäckberg, Matilda ^b   Hultén, Peter ^b   Al Saffar, Yasir ^a   Beck, Olof ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Swedish Poisons Information Centre   (Sweden)

Author keywords

Cannabinoids; Cathinones; NPS; Phenethylamines; Spice; Substance use disorder detection

Indexed keywords

4' METHYLMETHCATHINONE; AMPHETAMINE; CANNABINOID RECEPTOR AGONIST; CANNABIS; CATHINONE; DESIGNER DRUG; METHYLONE; PHENETHYLAMINE DERIVATIVE; PIPERAZINE DERIVATIVE; PSYCHOTROPIC AGENT; ALCOHOL; CENTRAL DEPRESSANT AGENT; NARCOTIC AGENT;

ARTICLE; DISEASE SEVERITY; DRUG INTOXICATION; EMERGENCY PATIENT; EMERGENCY WARD; HEALTH HAZARD; HUMAN; INTENSIVE CARE UNIT; LABORATORY TEST; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; POISONING SEVERITY SCORE; PRIORITY JOURNAL; SCORING SYSTEM; SUBSTANCE ABUSE; SWEDEN; SYMPTOMATOLOGY; ADOLESCENT; ADULT; BLOOD; CHEMISTRY; EMERGENCY HEALTH SERVICE; FEMALE; FORENSIC TOXICOLOGY; MALE; MIDDLE AGED; SUBSTANCE-RELATED DISORDERS; URINE; YOUNG ADULT;

ADOLESCENT; ADULT; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DESIGNER DRUGS; EMERGENCY SERVICE, HOSPITAL; ETHANOL; FEMALE; FORENSIC TOXICOLOGY; HUMANS; MALE; MIDDLE AGED; NARCOTICS; PSYCHOTROPIC DRUGS; SUBSTANCE-RELATED DISORDERS; SWEDEN; YOUNG ADULT;

EID: 84899480453     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2014.02.022     Document Type: Article

References (29)

1. United Nations Office on Drugs and Crime The Challenge of New Psychoactive Substances 2013, United Nations Office on Drugs and Crime, https://www.unodc.org/documents/scientific/NPS_Report.pdf.
2. Forman R.F., Marlowe D.B., McLellan A.T. The Internet as a source of drugs of abuse. Curr. Psychiatry Rep. 2006, 8:377-382.
3. Cottencin O., Rolland B., Karila L. New designer drugs (synthetic cannabinoids and synthetic cathinones): review of literature. Curr. Pharm. Des. 2013, 10.2174/13816128113199990622.
4. Gibbons S. 'Legal highs'-novel and emerging psychoactive drugs: a chemical overview for the toxicologist. Clin. Toxicol. (Phila.) 2012, 50:15-24.
5. Marriott K.S., Huffman J.W. Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor. Curr. Top. Med. Chem. 2008, 8:187-204.
6. Hill S.L., Thomas S.H. Clinical toxicology of newer recreational drugs. Clin. Toxicol. (Phila.) 2011, 49:705-719.
7. Prosser J.M., Nelson L.S. The toxicology of bath salts: a review of synthetic cathinones. J. Med. Toxicol. 2012, 8:33-42.
8. Seely K.A., Lapoint J., Moran J.H., Fattore L. Spice drugs are more than harmless herbal blends: a review of the pharmacology and toxicology of synthetic cannabinoids. Prog. Neuropsychopharmacol. Biol. Psychiatry 2012, 39:234-243.
9. Johnson L.A., Johnson R.L., Portier R.B. Current legal highs. J. Emerg. Med. 2013, 44:1108-1115.
10. European Monitoring Centre for Drugs and Drug Addiction 2012 Annual Report on the State of the Drugs Problem in Europe 2012, European Monitoring Centre for Drugs and Drug Addiction, http://www.emcdda.europa.eu/publications/annual-report/2012.
11. United Nations Office on Drugs and Crime UNODC Early Warning Advisory on New Psychoactive Substances (NPS) 2013, United Nations Office on Drugs and Crime, https://www.unodc.org/NPS.
12. Al-Saffar Y., Stephanson N.N., Beck O. Multicomponent LC-MS/MS screening method for detection of new psychoactive drugs, legal highs, in urine-experience from the Swedish population. J. Chromatogr. B 2013, 930:112-120.
13. Bell C., George C., Kicman A.T., Traynor A. Development of a rapid LC-MS/MS method for direct urinalysis of designer drugs. Drug Test. Anal. 2011, 3:496-504.
14. Björnstad K., Beck O., Helander A. A multi-component LC-MS/MS method for detection of ten plant-derived psychoactive substances in urine. J. Chromatogr. B 2009, 877:1162-1168.
15. Wohlfarth A., Weinmann W., Dresen S. LC-MS/MS screening method for designer amphetamines, tryptamines, and piperazines in serum. Anal. Bioanal. Chem. 2010, 396:2403-2414.
16. Helander A., Beck O., Hägerkvist R., Hulten P. Identification of novel psychoactive drug use in Sweden based on laboratory analysis-initial experiences from the STRIDA project. Scand. J. Clin. Lab. Invest. 2013, 73:400-406.
17. Persson H.E., Sjöberg G.K., Haines J.A., Pronczuk de Garbino J. Poisoning severity score. Grading of acute poisoning. J. Toxicol. Clin. Toxicol. 1998, 36:205-213.
18. Fattore L., Fratta W., Beyond T.H.C. The new generation of cannabinoid designer drugs. Front. Behav. Neurosci. 2011, 5:60.
19. The Swedish Council for Information on Alcohol and Other Drugs, Drug use among school children in 2012. CAN report 133, http://can.se/PageFiles/4621/skolelevers_drogvanor_2012.pdf?epslanguage=sv [in Swedish].
20. Wood K.E. Exposure to bath salts and synthetic tetrahydrocannabinol from 2009 to 2012 in the United States. J. Pediatr. 2013, 163:213-216.
21. Baron M., Elie M., Elie L. An analysis of legal highs: do they contain what it says on the tin?. Drug Test. Anal. 2011, 3:576-581.
22. Davies S., Wood D.M., Smith G., Button J., Ramsey J., Archer R., et al. Purchasing 'legal highs' on the internet-is there consistency in what you get. QJM 2010, 103:489-493.
23. Corkery J.M., Elliott S., Schifano F., Corazza O., Ghodse A.H. 2-DPMP (desoxypipradrol, 2-benzhydrylpiperidine, 2-phenylmethylpiperidine) and D2PM (diphenyl-2-pyrrolidin-2-yl-methanol, diphenylprolinol): a preliminary review. Prog. Neuropsychopharmacol. Biol. Psychiatry 2012, 39:253-258.
24. Kjellgren A., Soussan C. Heaven and hell-a phenomenological study of recreational use of 4-HO-MET in Sweden. J. Psychoact. Drugs 2011, 43:211-219.
25. Täljemark J., Johansson B.A. Drug-induced acute psychosis in an adolescent first-time user of 4-HO-MET. Eur. Child Adolesc. Psychiatry 2012, 21:527-528.
26. Wood D.M., Dargan P.I. Use and acute toxicity associated with the novel psychoactive substances diphenylprolinol (D2PM) and desoxypipradrol (2-DPMP). Clin. Toxicol. (Phila.) 2012, 50:727-732.
27. Loeffler G., Craig C. Methoxetamine misuse and toxicity. J. Stud. Alcohol Drugs 2013, 74:816-817.
28. Brents L.K., Prather P.L. The K2/Spice Phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products. Drug Metab. Rev. 2013, 10.3109/03602532.2013.839700.
29. Lindeman E., Hulten P., Ström S., Enlund M., Al-Saffar Y., Helander A. Increased abuse of the Internet drug MDPV in Västmanland. Severe cases of poisoning have given health care major problems. Läkartidningen 2012, 109:1954-1957. [in Swedish].