Neuronal changes and oxidative stress in adolescent rats after repeated exposure to mephedrone

Toxicology and Applied Pharmacology

Volumn 286, Issue 1, 2015, Pages 27-35

  López Arnau, Raúl ^a   Martínez Clemente, José ^a   Rodrigo, Teresa ^a   Pubill, David ^a   Camarasa, Jorge ^a   Escubedo, Elena ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Frontal cortex; Hippocampus; Mephedrone; Neurotoxicity; Rat; Striatum

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 4' METHYLMETHCATHINONE; CATALASE; CYCLOSPORIN A; DOPAMINE RECEPTOR; GLUTATHIONE PEROXIDASE; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; SEROTONIN; SEROTONIN 2A RECEPTOR; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; TRYPTOPHAN HYDROXYLASE 2; TYROSINE 3 MONOOXYGENASE; DESIGNER DRUG; DOPAMINE TRANSPORTER; METHAMPHETAMINE; SEROTONIN TRANSPORTER; STREET DRUG; TPH1 PROTEIN, RAT; TPH2 PROTEIN, RAT; TRYPTOPHAN HYDROXYLASE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORE TEMPERATURE; CORPUS STRIATUM; DOWN REGULATION; DRUG EXPOSURE; ENVIRONMENTAL TEMPERATURE; FRONTAL CORTEX; HIPPOCAMPUS; HYPOTHERMIA; LIPID PEROXIDATION; MALE; MEMORY; MORRIS WATER MAZE TEST; NONHUMAN; OXIDATIVE STRESS; RAT; REFERENCE MEMORY; SPATIAL LEARNING; THERMOREGULATION; WEIGHT GAIN; ANALOGS AND DERIVATIVES; ANIMAL; BODY TEMPERATURE; DRUG EFFECTS; FRONTAL LOBE; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; BODY TEMPERATURE; BODY WEIGHT; CATALASE; CORPUS STRIATUM; DESIGNER DRUGS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FRONTAL LOBE; GLUTATHIONE PEROXIDASE; HIPPOCAMPUS; MALE; MEMORY; METHAMPHETAMINE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; RATS, SPRAGUE-DAWLEY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SPATIAL LEARNING; STREET DRUGS; SUPEROXIDE DISMUTASE; TRYPTOPHAN HYDROXYLASE;

EID: 84939218027     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.03.015     Document Type: Article

References (53)

1. Açikgöz O., Gönenç S., Kayatekin B.M., Uysal N., Pekçetin C., Semin I., Güre A. Methamphetamine causes lipid peroxidation and an increase in superoxide dismutase activity in the rat striatum. Brain Res. 1998, 813:200-202.
2. Aksu I., Topcu A., Camsari U.M., Acikgoz O. Effect of acute and chronic exercise on oxidant-antioxidant equilibrium in rat hippocampus, prefrontal cortex and striatum. Neurosci. Lett. 2009, 452:281-285.
3. Amstad P., Moret R., Cerutti P. Glutathione peroxidase compensates for the hypersensitivity of Cu, Zn-superoxide dismutase overproducers to oxidant stress. J. Biol. Chem. 1994, 269:1606-1609.
4. Baumann M.H., Clark R.D., Rothman R.B. Locomotor stimulation produced by 3,4-methylenedioxymethamphetamine (MDMA) is correlated with dialysate levels of serotonin and dopamine in rat brain. Pharmacol. Biochem. Behav. 2008, 90:208-217.
5. Baumann M.H., Ayestas M.A., Partilla J.S., Sink J.R., Shulgin A.T., Daley P.F., Brandt S.D., Rothman R.B., Ruoho A.E., Cozzi N.V. The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue. Neuropsychopharmacology 2012, 37:1192-1203.
6. Brigelius-Flohé R. Tissue-specific functions of individual glutathione peroxidases. Free Radic. Biol. Med. 1999, 27:951-965.
7. Brunt T.M., Poortman A., Niesink R.J.M., van den Brink W. Instability of the ecstasy market and a new kid on the block: mephedrone. J. Psychopharmacol. 2011, 25:1543-1547.
8. Burger M.E., Fachinetto R., Zeni G., Rocha J.B.T. Ebselen attenuates haloperidol-induced orofacial dyskinesia and oxidative stress in rat brain. Pharmacol. Biochem. Behav. 2005, 81:608-615.
9. Cadet J.L., Brannock C. Free radicals and the pathobiology of brain dopamine systems. Neurochem. Int. 1998, 32:117-131.
10. Cadet J.L., Ladenheim B., Baum I., Carlson E., Epstein C. CuZn-superoxide dismutase (CuZnSOD) transgenic mice show resistance to the lethal effects of methylenedioxyamphetamine (MDA) and of methylenedioxymethamphetamine (MDMA). Brain Res. 1994, 655:259-262.
11. Cadet J.L., McCoy M.T., Cai N.S., Krasnova I.N., Ladenheim B., Beauvais G., Wilson N., Wood W., Becker K.G., Hodges A.B. Methamphetamine preconditioning alters midbrain transcriptional responses to methamphetamine-induced injury in the rat striatum. PLoS ONE 2009, 4:e7812.
12. Cameron K., Kolanos R., Verkariya R., De Felice L., Glennon R.A. Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of "bath salts", produce opposite effects at the human dopamine transporter. Psychopharmacol. (Berl.) 2013, 227:493-499.
13. Chiou W.L., Robbie G., Chung S.M., Wu T.C., Ma C. Correlation of plasma clearance of 54 extensively metabolized drugs between humans and rats: mean allometric coefficient of 0.66. Pharm. Res. 1998, 15:1474-1479.
14. Chipana C., García-Ratés S., Camarasa J., Pubill D., Escubedo E. Different oxidative profile and nicotinic receptor interaction of amphetamine and 3,4-methylenedioxy-methamphetamine. Neurochem. Int. 2008, 52:401-410.
15. Commins D.L., Vosmer G., Virus R.M., Woolverton W.L., Schuster C.R., Seiden L.S. Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain. J. Pharmacol. Exp. Ther. 1987, 241:338-345.
16. Da Silva D.D., Silva E., Carmo H. Combination effects of amphetamines under hyperthermia-the role played by oxidative stress. J. Appl. Toxicol. 2014, 34:637-650.
17. Den Hollander B., Rozov S., Linden A.-M., Uusi-Oukari M., Ojanperä I., Korpi E.R. Long-term cognitive and neurochemical effects of "bath salt" designer drugs methylone and mephedrone. Pharmacol. Biochem. Behav. 2013, 103:501-509.
18. Escubedo E., Chipana C., Pérez-Sánchez M., Camarasa J., Pubill D. Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors. J. Pharmacol. Exp. Ther. 2005, 315:658-667.
19. Fleckenstein A.E., Gibb J.W., Hanson G.R. Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity. Eur. J. Pharmacol. 2000, 406:1-13.
20. Freeman T.P., Morgan C.J., Vaughn-Jones J., Hussain N., Karimi K., Curran H.V. Cognitive and subjective effects of mephedrone and factors influencing use of a 'new legal high'. Addiction 2012, 107:792-800.
21. Hadlock G.C., Webb K.M., McFadden L.M., Chu P.W., Ellis J.D., Allen S.C., Andrenyak D.M., Vieira-Brock P.L., German C.L., Conrad K.M., Hoonakker A.J., Gibb J.W., Wilkins D.G., Hanson G.R., Fleckenstein A.E. 4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse. J. Pharmacol. Exp. Ther. 2011, 339:530-536.
22. Halliwell B. Antioxidants in human health and disease. Annu. Rev. Nutr. 1996, 16:33-50.
23. Halliwell B., Gutteridge J.M. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch. Biochem. Biophys. 1986, 246:501-514.
24. Haughey H.M., Fleckenstein A.E., Metzger R.R., Hanson G.R. The effects of methamphetamine on serotonin transporter activity: role of dopamine and hyperthermia. J. Neurochem. 2000, 75:1608-1617.
25. Hirata H., Ladenheim B., Carlson E., Epstein C., Cadet J.L. Autoradiographic evidence for methamphetamine-induced striatal dopaminergic loss in mouse brain: attenuation in CuZn-superoxide dismutase transgenic mice. Brain Res. 1996, 714:95-103.
26. Imam S.Z., el-Yazal J., Newport G.D., Itzhak Y., Cadet J.L., Slikker W., Ali S.F. Methamphetamine-induced dopaminergic neurotoxicity: role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalysts. Ann. N. Y. Acad. Sci. 2001, 939:366-380.
27. Imam S.Z., Newport G.D., Itzhak Y., Cadet J.L., Islam F., Slikker W., Ali S.F. Peroxynitrite plays a role in methamphetamine-induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper-zinc superoxide dismutase. J. Neurochem. 2001, 76:745-749.
28. Jayanthi S., Ladenheim B., Andrews A.M., Cadet J.L. Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (Ecstasy). Neuroscience 1999, 91:1379-1387.
29. Kehr J., Ichinose F., Yoshitake S., Goiny M., Sievertsson T., Nyberg F., Yoshitake T. Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats. Br. J. Pharmacol. 2011, 164:1949-1958.
30. Kelly J.P. Cathinone derivatives: a review of their chemistry, pharmacology and toxicology. Drug Test Anal. 2011, 3:439-453.
31. López-Arnau R., Martínez-Clemente J., Pubill D., Escubedo E., Camarasa J. Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methylone. Br. J. Pharmacol. 2012, 167:407-420.
32. Malberg J.E., Seiden L.S. Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat. J. Neurosci. 1998, 18:5086-5094.
33. Martínez-Clemente J., Escubedo E., Pubill D., Camarasa J. Interaction of mephedrone with dopamine and serotonin targets in rats. Eur. Neuropsychopharmacol. 2012, 22:231-236.
34. Martínez-Clemente J., López-Arnau R., Carbó M., Pubill D., Camarasa J., Escubedo E. Mephedrone pharmacokinetics after intravenous and oral administration in rats: relation to pharmacodynamics. Psychopharmacology (Berl.) 2013, 229:295-306.
35. Martínez-Clemente J., López-Arnau R., Abad S., Pubill D., Escubedo E., Camarasa J. Dose and time-dependent selective neurotoxicity induced by mephedrone in mice. PLoS ONE 2014, 9:e99002.
36. Metzger R.R., Haughey H.M., Wilkins D.G., Gibb J.W., Hanson G.R., Fleckenstein A.E. Methamphetamine-induced rapid decrease in dopamine transporter function: role of dopamine and hyperthermia. J. Pharmacol. Exp. Ther. 2000, 295:1077-1085.
37. Miller M.L., Creehan K.M., Angrish D., Barlow D.J., Houseknecht K.L., Dickerson T.J., Taffe M.A. Changes in ambient temperature differentially alter the thermoregulatory, cardiac and locomotor stimulant effects of 4-methylmethcathinone (mephedrone). Drug Alcohol Depend. 2013, 127:248-253.
38. Mizuno Y., Ohta K. Regional distributions of thiobarbituric acid-reactive products, activities of enzymes regulating the metabolism of oxygen free radicals, and some of the related enzymes in adult and aged rat brains. J. Neurochem. 1986, 46:1344-1352.
39. Motbey C.P., Karanges E., Li K.M., Wilkinson S., Winstock A.R., Ramsay J., Hicks C., Kendig M.D., Wyatt N., Callaghan P.D., McGregor I.S. Mephedrone in adolescent rats: residual memory impairment and acute but not lasting 5-HT depletion. PLoS ONE 2012, 7:e45473.
40. Orio L., O'Shea E., Sanchez V., Pradillo J.M., Escobedo I., Camarero J., Moro M.A., Green A.R., Colado M.I. 3,4-Methylenedioxymethamphetamine increases interleukin-1beta levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5-HT depletion. J. Neurochem. 2004, 89:1445-1453.
41. Palomero J., Galán A.I., Muñoz M.E., Tuñón M.J., González-Gallego J., Jiménez R. Effects of aging on the susceptibility to the toxic effects of cyclosporin A in rats. Changes in liver glutathione and antioxidant enzymes. Free Radic. Biol. Med. 2001, 30:836-845.
42. Prosser J.M., Nelson L.S. The toxicology of bath salts: a review of synthetic cathinones. J. Med. Toxicol. 2012, 8:33-42.
43. Pubill D., Canudas A.M., Pallàs M., Camins A., Camarasa J., Escubedo E. Different glial response to methamphetamine- and methylenedioxymethamphetamine-induced neurotoxicity. Naunyn Schmiedeberg's Arch. Pharmacol. 2003, 367:490-499.
44. Reddy S.K., Husain K., Schlorff E.C., Scott R.B., Somani S.M. Dose response of ethanol ingestion on antioxidant defense system in rat brain subcellular fractions. Neurotoxicology 1999, 20:977-987.
45. Sagara Y., Dargusch R., Klier F.G., Schubert D., Behl C. Increased antioxidant enzyme activity in amyloid beta protein-resistant cells. J. Neurosci. 1996, 16:497-505.
46. Schifano F., Albanese A., Fergus S., Stair J.L., Deluca P., Corazza O., Davey Z., Corkery J., Siemann H., Scherbaum N., Farre M., Torrens M., Demetrovics Z., Ghodse A.H., Psychonaut Web Mapping, ReDNet Research Groups Mephedrone (4-methylmethcathinone; "meow meow"): chemical, pharmacological and clinical issues. Psychopharmacol. (Berl.) 2011, 214:593-602.
47. Shortall S.E., Green A.R., Swift K.M., Fone K.C., King M.V. Differential effects of cathinone compounds and MDMA on body temperature in the rat, and pharmacological characterization of mephedrone-induced hypothermia. Br. J. Pharmacol. 2013, 168:966-977.
48. Vardakou I., Pistos C., Spiliopoulou C. Drugs for youth via Internet and the example of mephedrone. Toxicol. Lett. 2011, 201:191-195.
49. Vidal-Infer A., Roger-Sánchez C., Daza-Losada M., Aguilar M.A., Miñarro J., Rodríguez-Arias M. Role of the dopaminergic system in the acquisition, expression and reinstatement of MDMA-induced conditioned place preference in adolescent mice. PLoS ONE 2012, 7:e43107.
50. Volkow N.D., Fowler J.S., Wang G.-J., Swanson J.M. Dopamine in drug abuse and addiction: results from imaging studies and treatment implications. Mol. Psychiatry 2004, 9:557-569.
51. Winstock A., Mitcheson L., Ramsey J., Davies S., Puchnarewicz M., Marsden J. Mephedrone: use, subjective effects and health risks. Addict. Abingdon Engl. 2011, 106:1991-1996.
52. Xia Y., Dawson V.L., Dawson T.M., Snyder S.H., Zweier J.L. Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:6770-6774.
53. Yamamoto B.K., Zhu W. The effects of methamphetamine on the production of free radicals and oxidative stress. J. Pharmacol. Exp. Ther. 1998, 287:107-114.