Keto amphetamine toxicity-focus on the redox reactivity of the cathinone designer drug mephedrone

Toxicological Sciences

Volumn 141, Issue 1, 2014, Pages 120-131

  den Hollander, Bjørnar ^a   Sundström, Mira ^b   Pelander, Anna ^b   Ojanperä, Ilkka ^b   Mervaala, Eero ^a   Korpi, Esa Risto ^a   Kankuri, Esko ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cathinones; Mephedrone; Methamphetamine; Neurotoxicity; Protein adducts; Reducing agent; Respiratory chain; keto amphetamine

Indexed keywords

4' METHYLMETHCATHINONE; LACTATE DEHYDROGENASE; METHAMPHETAMINE; 2-(4-IODOPHENYL)-3-(4-NITROPHENYL)-5-(2,4-DISULFOPHENYL)-2H-TETRAZOLIUM; ALKALOID; AMINO ACID; CATHINONE; DESIGNER DRUG; TETRAZOLIUM;

ANIMAL CELL; ARTICLE; CYTOTOXICITY; ELECTRON TRANSPORT; ENZYME RELEASE; IN VITRO STUDY; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PH; RESPIRATORY CHAIN; RESPIROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; WST-1 ASSAY; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; C57BL MOUSE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION; OXYGEN CONSUMPTION; SMEGMAMORPHA; TUMOR CELL LINE;

ALKALOIDS; AMINO ACIDS; ANIMALS; BRAIN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DESIGNER DRUGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; METHAMPHETAMINE; MICE, INBRED C57BL; MITOCHONDRIA; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; SMEGMAMORPHA; TETRAZOLIUM SALTS;

EID: 84913615340     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu108     Document Type: Article

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