-
1
-
-
0033386744
-
Glutathione and N-acetylcysteine conjugates of α-methyldopamine produce serotonergic neurotoxicity: Possible role in methylenedioxyamphetamine- mediated neurotoxicity
-
Bai F, Lau SS, and Monks TJ (1999) Glutathione and N-acetylcysteine conjugates of α-methyldopamine produce serotonergic neurotoxicity: possible role in methylenedioxyamphetamine-mediated neurotoxicity. Chem Res Toxicol 12:1150-1157.
-
(1999)
Chem Res Toxicol
, vol.12
, pp. 1150-1157
-
-
Bai, F.1
Lau, S.S.2
Monks, T.J.3
-
2
-
-
0026662216
-
Biochemical and toxicological properties of the oxidation products of catecholamines
-
Bindoli A, Rigobello MP, and Deeble DJ (1992) Biochemical and toxicological properties of the oxidation products of catecholamines. Free Radic Biol Med 13:391-405.
-
(1992)
Free Radic Biol Med
, vol.13
, pp. 391-405
-
-
Bindoli, A.1
Rigobello, M.P.2
Deeble, D.J.3
-
3
-
-
0034068228
-
Role of quinones in toxicology
-
Bolton JL, Trush MA, Penning TM, Dryhurst G, and Monks TJ (2000) Role of quinones in toxicology. Chem Res Toxicol 13:135-160.
-
(2000)
Chem Res Toxicol
, vol.13
, pp. 135-160
-
-
Bolton, J.L.1
Trush, M.A.2
Penning, T.M.3
Dryhurst, G.4
Monks, T.J.5
-
5
-
-
1442278713
-
Hepatotoxicity of 3,4-methylenedioxyamphetamine and α- methyldopamine in isolated rat hepatocytes: Formation of glutathione conjugates
-
Carvalho M, Milhazes N, Remião F, Borges F, Fernandes E, Monks T, Amado F, Carvalho F, and Bastos ML (2004a) Hepatotoxicity of 3,4-methylenedioxyamphetamine and α-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates. Arch Toxicol 78:16-24.
-
(2004)
Arch Toxicol
, vol.78
, pp. 16-24
-
-
Carvalho, M.1
Milhazes, N.2
Remião, F.3
Borges, F.4
Fernandes, E.5
Monks, T.6
Amado, F.7
Carvalho, F.8
Bastos, M.L.9
-
6
-
-
2942714874
-
The toxicity of N-methyl-α-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine
-
Carvalho M, Remião F, Milhazes N, Borges F, Fernandes E, Carvalho F, and Bastos ML (2004b) The toxicity of N-methyl-α-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine. Toxicology 200:193-203.
-
(2004)
Toxicology
, vol.200
, pp. 193-203
-
-
Carvalho, M.1
Remião, F.2
Milhazes, N.3
Borges, F.4
Fernandes, E.5
Carvalho, F.6
Bastos, M.L.7
-
7
-
-
2442639021
-
Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro
-
Carvalho M, Remião F, Milhazes N, Borges F, Fernandes E, Monteiro MC, Gonçalves MJ, Seabra V, Amado F, Carvalho F, and Bastos ML (2004c) Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro. Chem Res Toxicol 17:623-632.
-
(2004)
Chem Res Toxicol
, vol.17
, pp. 623-632
-
-
Carvalho, M.1
Remião, F.2
Milhazes, N.3
Borges, F.4
Fernandes, E.5
Monteiro, M.C.6
Gonçalves, M.J.7
Seabra, V.8
Amado, F.9
Carvalho, F.10
Bastos, M.L.11
-
8
-
-
0029916656
-
Disposition of methylenodioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion
-
Chu T, Kumagai Y, DiStefano EW, and Cho AK (1996) Disposition of methylenodioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion. Biochem Pharmacol 51:789-796.
-
(1996)
Biochem Pharmacol
, vol.51
, pp. 789-796
-
-
Chu, T.1
Kumagai, Y.2
DiStefano, E.W.3
Cho, A.K.4
-
9
-
-
0030986255
-
In vivo evidence for free radical involvement in 5-HT following administration of MDMA ("ecstasy") and p-chloroamphetamine but not the degeneration following fenfluramine
-
Colado MI, O'Shea E, Granados R, Murray TK, and Green AR (1997) In vivo evidence for free radical involvement in 5-HT following administration of MDMA ("ecstasy") and p-chloroamphetamine but not the degeneration following fenfluramine. Br J Pharmacol 121:889-900.
-
(1997)
Br J Pharmacol
, vol.121
, pp. 889-900
-
-
Colado, M.I.1
O'Shea, E.2
Granados, R.3
Murray, T.K.4
Green, A.R.5
-
10
-
-
0023255308
-
Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain
-
Commins DL, Vosmer G, Virus RM, Woolverton WL, Schuster CR, and Seiden LS (1987) Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain. J Pharmacol Exp Ther 241:338-345.
-
(1987)
J Pharmacol Exp Ther
, vol.241
, pp. 338-345
-
-
Commins, D.L.1
Vosmer, G.2
Virus, R.M.3
Woolverton, W.L.4
Schuster, C.R.5
Seiden, L.S.6
-
11
-
-
0035084704
-
3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose
-
Esteban B, O'Shea E, Camarero J, Sanchez V, Green AR, and Colado MI (2001) 3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose. Psychopharmacology 154:251-260.
-
(2001)
Psychopharmacology
, vol.154
, pp. 251-260
-
-
Esteban, B.1
O'Shea, E.2
Camarero, J.3
Sanchez, V.4
Green, A.R.5
Colado, M.I.6
-
12
-
-
0041530022
-
Tissue concentrations of MDMA and its metabolite MDA in three fatal cases of overdose
-
García-Repetto R, Moreno E, Soriano T, Jurado C, Gimenez MP, and Menendez M (2003) Tissue concentrations of MDMA and its metabolite MDA in three fatal cases of overdose. Forensic Sci Int 135:110-114.
-
(2003)
Forensic Sci Int
, vol.135
, pp. 110-114
-
-
García-Repetto, R.1
Moreno, E.2
Soriano, T.3
Jurado, C.4
Gimenez, M.P.5
Menendez, M.6
-
13
-
-
0041466261
-
The pharmacology and clinical pharmacology of 3,4- methylenedioxymethamphetamine (MDMA, "Ecstasy")
-
Green AR, Mechan AO, Elliot JM, O'Shea E, and Colado MI (2003) The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"). Pharmacol Rev 55:463-508.
-
(2003)
Pharmacol Rev
, vol.55
, pp. 463-508
-
-
Green, A.R.1
Mechan, A.O.2
Elliot, J.M.3
O'Shea, E.4
Colado, M.I.5
-
14
-
-
0026754574
-
Reactive oxygen species and the central nervous system
-
Halliwell B (1992) Reactive oxygen species and the central nervous system. J Neurochem 59:1609-1623.
-
(1992)
J Neurochem
, vol.59
, pp. 1609-1623
-
-
Halliwell, B.1
-
15
-
-
0026684873
-
Ecstasy and the dance of death
-
Henry JA (1992) Ecstasy and the dance of death. Br Med J 305:5-6.
-
(1992)
Br Med J
, vol.305
, pp. 5-6
-
-
Henry, J.A.1
-
16
-
-
0025121255
-
Metabolism of methylenedioxymethamphetamine: Formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct
-
Hiramatsu M, Kumagai Y, Unger SE, and Cho AK (1990) Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct. J Pharmacol Exp Ther 254:521-527.
-
(1990)
J Pharmacol Exp Ther
, vol.254
, pp. 521-527
-
-
Hiramatsu, M.1
Kumagai, Y.2
Unger, S.E.3
Cho, A.K.4
-
17
-
-
15744365687
-
Serotonergic neurotoxic metabolites of ecstasy identified in rat brain
-
Jones DC, Duvauchelle C, Ikegami A, Olsen CM, Lau SS, de la Torre R, and Monks TJ (2005) Serotonergic neurotoxic metabolites of ecstasy identified in rat brain. J Pharmacol Exp Ther 313:422-431.
-
(2005)
J Pharmacol Exp Ther
, vol.313
, pp. 422-431
-
-
Jones, D.C.1
Duvauchelle, C.2
Ikegami, A.3
Olsen, C.M.4
Lau, S.S.5
De La Torre, R.6
Monks, T.J.7
-
18
-
-
0025303448
-
Evidence for carrier mediated transport of glutathione across the blood-brain barrier in the rat
-
Kannan R, Kuhlenkamp JF, Jeandidier E, Trinh H, Ookhtens M, and Kaplowitz N (1990) Evidence for carrier mediated transport of glutathione across the blood-brain barrier in the rat. J Clin Investig 85:2009-2013.
-
(1990)
J Clin Investig
, vol.85
, pp. 2009-2013
-
-
Kannan, R.1
Kuhlenkamp, J.F.2
Jeandidier, E.3
Trinh, H.4
Ookhtens, M.5
Kaplowitz, N.6
-
19
-
-
0031741895
-
Immunochemical detection of quinol-thioether-derived covalent protein adducts
-
Kleiner HE, Rivera MI, Pumford NR, Monks TJ, and Lau SS (1998) Immunochemical detection of quinol-thioether-derived covalent protein adducts. Chem Res Toxicol 11:1283-1290.
-
(1998)
Chem Res Toxicol
, vol.11
, pp. 1283-1290
-
-
Kleiner, H.E.1
Rivera, M.I.2
Pumford, N.R.3
Monks, T.J.4
Lau, S.S.5
-
20
-
-
0025756894
-
Hydroxyl radical mediated demethylenation of (methylenedioxy)-phenyl compounds
-
Kumagai Y, Lin LY, Schmitz DA, and Cho AK (1991) Hydroxyl radical mediated demethylenation of (methylenedioxy)-phenyl compounds. Chem Res Toxicol 4:330-334.
-
(1991)
Chem Res Toxicol
, vol.4
, pp. 330-334
-
-
Kumagai, Y.1
Lin, L.Y.2
Schmitz, D.A.3
Cho, A.K.4
-
21
-
-
0034010045
-
Role of nitric oxide in the ethylcholine aziridinium (AF64A) model of delayed apoptotic neurodegeneration in vivo and in vitro
-
Lautenschlager M, Onufriev MV, Gulyaeva NV, Harms C, Freyer D, Sehmsdorf US, Ruscher K, Moiseeva YV, Arnswald A, et al. (2000) Role of nitric oxide in the ethylcholine aziridinium (AF64A) model of delayed apoptotic neurodegeneration in vivo and in vitro. Neuroscience 97:383-393.
-
(2000)
Neuroscience
, vol.97
, pp. 383-393
-
-
Lautenschlager, M.1
Onufriev, M.V.2
Gulyaeva, N.V.3
Harms, C.4
Freyer, D.5
Sehmsdorf, U.S.6
Ruscher, K.7
Moiseeva, Y.V.8
Arnswald, A.9
-
22
-
-
0024214871
-
In vivo and in vitro metabolism of 3,4-(methylenedioxy) methamphetamine in the rat: Identification of metabolites using an ion trap detector
-
Lim HK and Foltz RL (1988) In vivo and in vitro metabolism of 3,4-(methylenedioxy) methamphetamine in the rat: identification of metabolites using an ion trap detector. Chem Res Toxicol 1:370-378.
-
(1988)
Chem Res Toxicol
, vol.1
, pp. 370-378
-
-
Lim, H.K.1
Foltz, R.L.2
-
23
-
-
0028997389
-
Metabolism of 5-(GSyl)-α-methyldopamine following intracerebroventricular administration to male Sprague-Dawley rats
-
Miller RT, Lau SS, and Monks TJ (1995) Metabolism of 5-(GSyl)-α- methyldopamine following intracerebroventricular administration to male Sprague-Dawley rats. Chem Res Toxicol 8:634-641.
-
(1995)
Chem Res Toxicol
, vol.8
, pp. 634-641
-
-
Miller, R.T.1
Lau, S.S.2
Monks, T.J.3
-
24
-
-
0029884986
-
Effect of 5-(GSyl)-α-methyldopamine on dopamine, serotonin and norepinephrine concentrations following intracerebroventricular administration to male Sprague-Dawley rats
-
Miller RT, Lau SS, and Monks TJ (1996) Effect of 5-(GSyl)-α- methyldopamine on dopamine, serotonin and norepinephrine concentrations following intracerebroventricular administration to male Sprague-Dawley rats. Chem Res Toxicol 9:457-465.
-
(1996)
Chem Res Toxicol
, vol.9
, pp. 457-465
-
-
Miller, R.T.1
Lau, S.S.2
Monks, T.J.3
-
25
-
-
0030951385
-
2,5-Bis-(GSyl)-α-methyldopamine, a putative metabolite of (±)-3,4-methylenedioxyamphetamine, decreases brain serotonin concentrations
-
Miller RT, Lau SS, and Monks TJ (1997) 2,5-Bis-(GSyl)-α- methyldopamine, a putative metabolite of (±)-3,4- methylenedioxyamphetamine, decreases brain serotonin concentrations. Eur J Pharmacol 323:173-180.
-
(1997)
Eur J Pharmacol
, vol.323
, pp. 173-180
-
-
Miller, R.T.1
Lau, S.S.2
Monks, T.J.3
-
26
-
-
4143053372
-
The role of metabolism in 3,4-methylenodioxyamphetamine 3,4-methylenodioxymethamphetamine (Ecstasy) toxicity
-
Monks TJ, Jones DC, Bai F, and Lau SS (2004) The role of metabolism in 3,4-methylenodioxyamphetamine 3,4-methylenodioxymethamphetamine (Ecstasy) toxicity. Ther Drug Monit 26:132-136.
-
(2004)
Ther Drug Monit
, vol.26
, pp. 132-136
-
-
Monks, T.J.1
Jones, D.C.2
Bai, F.3
Lau, S.S.4
-
27
-
-
0026598872
-
Lack of serotonin neurotoxicity after intraraphe microinjection of (+)-3,4-methylenedioxymethamphetamine (MDMA)
-
Paris JM and Cunningham KA (1992) Lack of serotonin neurotoxicity after intraraphe microinjection of (+)-3,4-methylenedioxymethamphetamine (MDMA). Brain Res Bull 28:115-119.
-
(1992)
Brain Res Bull
, vol.28
, pp. 115-119
-
-
Paris, J.M.1
Cunningham, K.A.2
-
28
-
-
0036119214
-
Recreational Ecstasy/MDMA, the serotonin syndrome and serotonergic neurotoxicity
-
Parrott AC (2002) Recreational Ecstasy/MDMA, the serotonin syndrome and serotonergic neurotoxicity. Pharmacol Biochem Behav 71:837-844.
-
(2002)
Pharmacol Biochem Behav
, vol.71
, pp. 837-844
-
-
Parrott, A.C.1
-
29
-
-
12444321929
-
Chronic tolerance to recreational MDMA (3,4- methylenedioxymethamphetamine) or Ecstasy
-
Parrott AC (2005) Chronic tolerance to recreational MDMA (3,4-methylenedioxymethamphetamine) or Ecstasy. J Psychopharmacol 19:71-83.
-
(2005)
J Psychopharmacol
, vol.19
, pp. 71-83
-
-
Parrott, A.C.1
-
30
-
-
0035998297
-
Cu2+-induced isoproterenol oxidation into isoprenochrome in adult rat calcium-tolerant cardiomyocytes
-
Remião F, Carvalho M, Carmo H, Carvalho FD, and Bastos ML (2002) Cu2+-induced isoproterenol oxidation into isoprenochrome in adult rat calcium-tolerant cardiomyocytes. Chem Res Toxicol 15:861-869.
-
(2002)
Chem Res Toxicol
, vol.15
, pp. 861-869
-
-
Remião, F.1
Carvalho, M.2
Carmo, H.3
Carvalho, F.D.4
Bastos, M.L.5
-
31
-
-
0033623773
-
(±)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: Studies in animals
-
Ricaurte GA, Yuan J, and McCann UD (2000) (±)3,4- Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: studies in animals. Neuropsychobiology 42:5-10.
-
(2000)
Neuropsychobiology
, vol.42
, pp. 5-10
-
-
Ricaurte, G.A.1
Yuan, J.2
McCann, U.D.3
-
32
-
-
0037651111
-
Demonstration and localization of neuronal degeneration in the rat forebrain following a single exposure to MDMA
-
Schmued LC (2003) Demonstration and localization of neuronal degeneration in the rat forebrain following a single exposure to MDMA. Brain Res 974:127-133.
-
(2003)
Brain Res
, vol.974
, pp. 127-133
-
-
Schmued, L.C.1
-
33
-
-
0034812738
-
3,4-Dihydroxymetamphetamine (HHMA). A major in vivo 3,4- methylenedioxymethamphetamine (MDMA) metabolite in humans
-
Segura M, Ortuno J, Farre M, McLure JA, Pujadas M, Pizarro N, Llebaria A, Joglar J, Roset PN, Segura J, and de La Torre R (2001) 3,4- Dihydroxymetamphetamine (HHMA). A major in vivo 3,4- methylenedioxymethamphetamine (MDMA) metabolite in humans. Chem Res Toxicol 14:1203-1208.
-
(2001)
Chem Res Toxicol
, vol.14
, pp. 1203-1208
-
-
Segura, M.1
Ortuno, J.2
Farre, M.3
McLure, J.A.4
Pujadas, M.5
Pizarro, N.6
Llebaria, A.7
Joglar, J.8
Roset, P.N.9
Segura, J.10
De La Torre, R.11
-
34
-
-
0031017564
-
The abused drug MDMA (Ecstasy) induces programmed death of human serotonergic cells
-
Simantov R and Tauber M (1997) The abused drug MDMA (Ecstasy) induces programmed death of human serotonergic cells. FASEB J 11:141-146.
-
(1997)
FASEB J
, vol.11
, pp. 141-146
-
-
Simantov, R.1
Tauber, M.2
-
35
-
-
0029078456
-
The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits
-
Sprague JE and Nichols DE (1995) The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits. J Pharmacol Exp Ther 273:667-673.
-
(1995)
J Pharmacol Exp Ther
, vol.273
, pp. 667-673
-
-
Sprague, J.E.1
Nichols, D.E.2
-
36
-
-
0032968347
-
Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons
-
Stumm G, Schlegel J, Schafer T, Wurz C, Mennel HD, Krieg JC, and Vedder H (1999) Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons. FASEB J 13:1065-1072.
-
(1999)
FASEB J
, vol.13
, pp. 1065-1072
-
-
Stumm, G.1
Schlegel, J.2
Schafer, T.3
Wurz, C.4
Mennel, H.D.5
Krieg, J.C.6
Vedder, H.7
-
37
-
-
0033103959
-
N-tert-Butyl-alpha-phenylnitrone protects against 3,4- methylenedioxymethamphetamine-induced depletion of serotonin in rats
-
Yeh SY (1999) N-tert-Butyl-alpha-phenylnitrone protects against 3,4-methylenedioxymethamphetamine-induced depletion of serotonin in rats. Synapse 31:169-177.
-
(1999)
Synapse
, vol.31
, pp. 169-177
-
-
Yeh, S.Y.1
-
38
-
-
0028215392
-
Effects of L-cysteine on the oxidation chemistry of dopamine: New reaction pathways of potential relevance to idiopathic Parkinson's disease
-
Zhang F and Dryhurst G (1994) Effects of L-cysteine on the oxidation chemistry of dopamine: new reaction pathways of potential relevance to idiopathic Parkinson's disease. J Med Chem 37:1084-1098.
-
(1994)
J Med Chem
, vol.37
, pp. 1084-1098
-
-
Zhang, F.1
Dryhurst, G.2
|