Novel quercetin derivative TEF induces ER stress and mitochondria-mediated apoptosis in human colon cancer HCT-116 cells

Biomedicine and Pharmacotherapy

Volumn 84, Issue , 2016, Pages 789-799

  Khan, Imran ^a   Paul, Souren ^a   Jakhar, Rekha ^a   Bhardwaj, Monika ^a   Han, Jaehong ^b   Kang, Sun Chul ^a  

^a Daegu University   (South Korea)

^b Chung Ang University   (South Korea)

Author keywords

Apoptosis; Mitochondria; Quercetin; TEF

Indexed keywords

5,3' DIHYDROXY 3,7,4' TRIETHOXYFLAVONE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; CALCIUM ION; CALNEXIN; CASPASE 3; CASPASE 9; CYTOCHROME C; DNA; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OXALIPLATIN; PROTEIN BCL 2; PROTEIN IRE1; PROTEIN IRE1 ALPHA; QUERCETIN; QUERCETIN DERIVATIVE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; SILANE DERIVATIVE; TRIETHOXYFLUOROSILANE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SENSITIZATION; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; HCT116 CELL LINE; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CHEMISTRY; COLONIC NEOPLASMS; DOSE RESPONSE; DRUG EFFECTS; HCT 116 CELL LINE; METABOLISM; PHYSIOLOGY;

APOPTOSIS; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; HCT116 CELLS; HUMANS; MITOCHONDRIA; OXIDATIVE STRESS; QUERCETIN; REACTIVE OXYGEN SPECIES; SILANES;

EID: 84990929274     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.09.094     Document Type: Article

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