메뉴 건너뛰기




Volumn 82, Issue , 2016, Pages 161-170

Quercetin derivatives as novel antihypertensive agents: Synthesis and physiological characterization

Author keywords

Heart; Hypertension; Nitric oxide; Quercetin

Indexed keywords

ACETIC ACID DERIVATIVE; ALPHA 2 ADRENERGIC RECEPTOR; ANTIHYPERTENSIVE AGENT; BETA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; HYDROXYL GROUP; N(G) NITROARGININE METHYL ESTER; QUERCETIN; QUERCETIN DERIVATIVE; BETA 2 ADRENERGIC RECEPTOR; PANCREATIN; PEPSIN A;

EID: 84949033474     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.11.021     Document Type: Article
Times cited : (50)

References (32)
  • 1
    • 0034108013 scopus 로고    scopus 로고
    • Bioavailability and metabolism of the flavonol quercetin in the pig
    • P. Ader, A. Wessmann, and S. Wolffram Bioavailability and metabolism of the flavonol quercetin in the pig Free Radic. Biol. Med. 28 2000 1056 1067
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 1056-1067
    • Ader, P.1    Wessmann, A.2    Wolffram, S.3
  • 3
    • 79954629254 scopus 로고    scopus 로고
    • Distinct signalling mechanisms are involved in the dissimilar myocardial and coronary effects elicited by quercetin and myricetin, two red wine flavonols
    • T. Angelone, T. Pasqua, D. Di Majo, A.M. Quintieri, E. Filice, N. Amodio, B. Tota, M. Giammanco, and M.C. Cerra Distinct signalling mechanisms are involved in the dissimilar myocardial and coronary effects elicited by quercetin and myricetin, two red wine flavonols Nutr. Metab. Cardiovasc. Dis. 21 2011 362 371
    • (2011) Nutr. Metab. Cardiovasc. Dis. , vol.21 , pp. 362-371
    • Angelone, T.1    Pasqua, T.2    Di Majo, D.3    Quintieri, A.M.4    Filice, E.5    Amodio, N.6    Tota, B.7    Giammanco, M.8    Cerra, M.C.9
  • 5
    • 0037049272 scopus 로고    scopus 로고
    • Hemisynthesis of all the O-monomethylated analogues of quercetin including the major metabolites, through selective protection of phenolic functions
    • M. Bouktaib, S. Lebrun, A. Atmanib, and C. Rolando Hemisynthesis of all the O-monomethylated analogues of quercetin including the major metabolites, through selective protection of phenolic functions Tetrahedron 58 2002 10001 10009
    • (2002) Tetrahedron , vol.58 , pp. 10001-10009
    • Bouktaib, M.1    Lebrun, S.2    Atmanib, A.3    Rolando, C.4
  • 6
    • 33747594330 scopus 로고    scopus 로고
    • Cardiac adrenoceptors: Physiological and pathophysiological relevance
    • O.E. Brodde, H. Bruck, and K. Leineweber Cardiac adrenoceptors: physiological and pathophysiological relevance J. Pharmacol. Sci. 100 2006 323 337
    • (2006) J. Pharmacol. Sci. , vol.100 , pp. 323-337
    • Brodde, O.E.1    Bruck, H.2    Leineweber, K.3
  • 7
    • 84877998754 scopus 로고    scopus 로고
    • Bioavailability of quercetin: Problems and promises
    • X. Cai, Z. Fang, J. Dou, A. Yu, and G. Zhai Bioavailability of quercetin: problems and promises Curr. Med. Chem. 20 2013 2572 2582
    • (2013) Curr. Med. Chem. , vol.20 , pp. 2572-2582
    • Cai, X.1    Fang, Z.2    Dou, J.3    Yu, A.4    Zhai, G.5
  • 8
    • 84886946656 scopus 로고    scopus 로고
    • Biological activity of 3-chloro-azetidin-2-one derivatives having interesting antiproliferative activity on human breast cancer cell lines
    • P. Campiglia, and V. Pezzi Biological activity of 3-chloro-azetidin-2-one derivatives having interesting antiproliferative activity on human breast cancer cell lines Bioorg. Med. Chem. Lett. 23 2013 6401 6405
    • (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 6401-6405
    • Campiglia, P.1    Pezzi, V.2
  • 13
    • 0025885064 scopus 로고
    • Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia
    • E.E. Deschner, J. Ruperto, G. Wong, and H.L. Newmark Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia Carcinogenesis 12 1991 1193 1196
    • (1991) Carcinogenesis , vol.12 , pp. 1193-1196
    • Deschner, E.E.1    Ruperto, J.2    Wong, G.3    Newmark, H.L.4
  • 16
    • 0029999052 scopus 로고    scopus 로고
    • Phase I clinical trial of the flavonoid quercetin: Pharmacokinetics and evidence for in vivo tyrosine kinase inhibition
    • D.R. Ferry, A. Smith, J. Malkhandi, D.W. Fyfe, P.G. deTakats, D. Anderson, J. Baker, and D.J. Kerr Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition Clin. Cancer Res. 2 1996 659 668
    • (1996) Clin. Cancer Res. , vol.2 , pp. 659-668
    • Ferry, D.R.1    Smith, A.2    Malkhandi, J.3    Fyfe, D.W.4    DeTakats, P.G.5    Anderson, D.6    Baker, J.7    Kerr, D.J.8
  • 17
    • 0016811010 scopus 로고
    • Disposition of quercetin in man after single oral and intravenous doses
    • R. Gugler, M. Leschik, and H.J. Dengler Disposition of quercetin in man after single oral and intravenous doses Eur. J. Clin. Pharmacol. 9 1975 229 234
    • (1975) Eur. J. Clin. Pharmacol. , vol.9 , pp. 229-234
    • Gugler, R.1    Leschik, M.2    Dengler, H.J.3
  • 18
    • 0031472264 scopus 로고    scopus 로고
    • Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation
    • T. Hayek, B. Fuhrman, J. Vaya, M. Rosenblat, P. Belinky, R. Coleman, A. Elis, and M. Aviram Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation Arterioscler. Thromb. Vasc. Biol. 17 1997 2744 2752
    • (1997) Arterioscler. Thromb. Vasc. Biol. , vol.17 , pp. 2744-2752
    • Hayek, T.1    Fuhrman, B.2    Vaya, J.3    Rosenblat, M.4    Belinky, P.5    Coleman, R.6    Elis, A.7    Aviram, M.8
  • 19
    • 0035538409 scopus 로고    scopus 로고
    • Antioxidants in fruits and vegetables - The millennium's health
    • C. Kaur, and H.C. Kapoor Antioxidants in fruits and vegetables - the millennium's health Int. J. Food Sci. Technol. 36 2001 703 725
    • (2001) Int. J. Food Sci. Technol. , vol.36 , pp. 703-725
    • Kaur, C.1    Kapoor, H.C.2
  • 20
    • 78650321830 scopus 로고    scopus 로고
    • Enhanced stability and intracellular accumulation of quercetin by protection of the chemically or metabolically susceptible hydroxyl groups with a pivaloxymethyl (POM) promoiety
    • M.K. Kim, K.S. Park, C. Lee, H.R. Park, H. Choo, and Y. Chong Enhanced stability and intracellular accumulation of quercetin by protection of the chemically or metabolically susceptible hydroxyl groups with a pivaloxymethyl (POM) promoiety J. Med. Chem. 53 2010 8597 8607
    • (2010) J. Med. Chem. , vol.53 , pp. 8597-8607
    • Kim, M.K.1    Park, K.S.2    Lee, C.3    Park, H.R.4    Choo, H.5    Chong, Y.6
  • 21
    • 77951949716 scopus 로고    scopus 로고
    • Quercetin: A treatment for hypertension? - A review of efficacy and mechanisms
    • A.J. Larson, J.D. Symons, and T. Jalili Quercetin: a treatment for hypertension? - a review of efficacy and mechanisms Pharmaceuticals 3 2010 237 250
    • (2010) Pharmaceuticals , vol.3 , pp. 237-250
    • Larson, A.J.1    Symons, J.D.2    Jalili, T.3
  • 26
    • 0020374878 scopus 로고
    • Pentasubstituted quercetin analogues as selective inhibitors of particulate 3′:5′-cyclic-AMP phosphodiesterase from rat brain
    • M. Picq, A.F. Prigent, G. Ngmoz, A.C. Andrè, and H. Pacheco Pentasubstituted quercetin analogues as selective inhibitors of particulate 3′:5′-cyclic-AMP phosphodiesterase from rat brain J. Med. Chem. 25 1982 1192 1198
    • (1982) J. Med. Chem. , vol.25 , pp. 1192-1198
    • Picq, M.1    Prigent, A.F.2    Ngmoz, G.3    Andrè, A.C.4    Pacheco, H.5
  • 27
    • 0033753482 scopus 로고    scopus 로고
    • The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide
    • P. Pignatelli, F.M. Pulcinelli, A. Celestini, L. Lenti, A. Ghiselli, P.P. Gazzaniga, and F. Violi The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide Am. J. Clin. Nutr. 72 2000 1150 1155
    • (2000) Am. J. Clin. Nutr. , vol.72 , pp. 1150-1155
    • Pignatelli, P.1    Pulcinelli, F.M.2    Celestini, A.3    Lenti, L.4    Ghiselli, A.5    Gazzaniga, P.P.6    Violi, F.7
  • 28
    • 77955284662 scopus 로고    scopus 로고
    • Oral bioavailability of quercetin from different quercetin glycosides in dogs
    • M. Reinboth, S. Wolffram, G. Abraham, F.R. Ungemach, and R. Cermak Oral bioavailability of quercetin from different quercetin glycosides in dogs Br. J. Nutr. 104 2010 198 203
    • (2010) Br. J. Nutr. , vol.104 , pp. 198-203
    • Reinboth, M.1    Wolffram, S.2    Abraham, G.3    Ungemach, F.R.4    Cermak, R.5
  • 30
    • 0023681264 scopus 로고
    • Inhibition of 7,12-dimethylbenz(a)anthracene and N-nitrosomethylurea induced mammary cancer by dietary flavonol quercetin
    • A.K. Verma, J.A. Johnson, M.N. Gould, and M.A. Tanner Inhibition of 7,12-dimethylbenz(a)anthracene and N-nitrosomethylurea induced mammary cancer by dietary flavonol quercetin Cancer Res. 48 1988 5754 5788
    • (1988) Cancer Res. , vol.48 , pp. 5754-5788
    • Verma, A.K.1    Johnson, J.A.2    Gould, M.N.3    Tanner, M.A.4
  • 31
    • 33751014319 scopus 로고    scopus 로고
    • Inhibition of cardiac voltage-gated sodium channels by grape polyphenols
    • C.H.R. Wallace, I. Baczko, L. Jones, M. Fercho, and P.E. Light Inhibition of cardiac voltage-gated sodium channels by grape polyphenols Br. J. Pharmacol. 149 6 2006 657 665
    • (2006) Br. J. Pharmacol. , vol.149 , Issue.6 , pp. 657-665
    • Wallace, C.H.R.1    Baczko, I.2    Jones, L.3    Fercho, M.4    Light, P.E.5
  • 32
    • 84858127346 scopus 로고    scopus 로고
    • Beta-adrenergic receptor subtype signaling in heart: From bench to bedside
    • A.Y. Woo, and R.P. Xiao Beta-adrenergic receptor subtype signaling in heart: from bench to bedside Acta Pharmacol. Sin. 33 2002 335 341
    • (2002) Acta Pharmacol. Sin. , vol.33 , pp. 335-341
    • Woo, A.Y.1    Xiao, R.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.