Exogenous thioredoxin prevents ethanol-induced oxidative damage and apoptosis in mouse liver

Hepatology

Volumn 49, Issue 5, 2009, Pages 1709-1717

  Cohen, Jessica I ^a,b   Roychowdhury, Sanjoy ^b   DiBello, Patricia M ^b   Jacobsen, Donald W ^b   Nagy, Laura E ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; BIOTIN; CASPASE 3; CYTOKERATIN 18; CYTOKINE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; PHOSPHATE BUFFERED SALINE; THIOREDOXIN; THIOREDOXIN 1; TRIACYLGLYCEROL; RECOMBINANT PROTEIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOLIC FATTY LIVER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; LIPID LIVER LEVEL; LIVER CELL; LIVER INJURY; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; ALCOHOL LIVER DISEASE; ANIMAL; C57BL MOUSE; DRUG EFFECT; HUMAN; LIVER; METABOLISM;

ANIMALS; APOPTOSIS; CYTOKINES; ETHANOL; FEMALE; HUMANS; LIVER; LIVER DISEASES, ALCOHOLIC; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; RECOMBINANT PROTEINS; THIOREDOXINS;

EID: 66149103602     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22837     Document Type: Article

References (50)

1. Nakamura H. Thioredoxin as a key molecule in redox signaling. Antioxid Redox Signal 2004;6:15-17.
2. Holmgren A. Thioredoxin. Annu Rev Biochem 1985;54:237-271.
3. Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 1998;17:2596-2606.
4. Powis G, Montfort WR. Properties and biological activities of thioredoxins. Annu Rev Biophys Biomol Struct 2001;30:421-455.
5. Nakamura H, Mitsui A, Yodoi J. Thioredoxin overexpression in transgenic mice. Methods Enzymol 2002;347:436-440.
6. Ohashi S, Nishio A, Nakamura H, Asada M, Tamaki H, Kawasaki K, et al. Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice. Antioxid Redox Signal 2006;8:1835-1845.
7. Tamaki H, Nakamura H, Nishio A, Nakase H, Ueno S, Uza N, et al. Human thioredoxin-1 ameliorates experimental murine colitis in association with suppressed macrophage inhibitory factor production. Gastroenterology 2006;131:1110-1121.
8. Arteel GE. Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 2003;124:778-790.
9. Hoek JB, Pastorino JG. Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol 2002;27:63-68.
10. Thurman RG. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol 1998;275:G605-G611.
11. Kono H, Rusyn I, Yin M, Gabele E, Yamashina S, Dikalova A, et al. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 2000;106:867-872.
12. Thakur V, Pritchard MT, McMullen MR, Wang Q, Nagy LE. Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: Role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production. J Leukoc Biol 2006;79: 138-1356.
13. Cederbaum AI. Introduction-serial review: Alcohol, oxidative stress and cell injury. Free Radic Biol Med 2001;31:1524-1526.
14. Lu Y, Zhuge J, Wang X, Bai J, Cederbaum AI. Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. HEPATOLOGY 2008;47: 1483-1494.
15. Yin M, Wheeler MD, Kono H, Bradford BU, Gallucci RM, Luster MI, et al. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Gastroenterology 1999;117:942-952.
16. McVicker BL, Tuma DJ, Casey CA. Effect of ethanol on pro-apoptotic mechanisms in polarized hepatic cells. World J Gastroenterol 2007;13: 4960-4966.
17. Higuchi H, Adachi M, Miura S, Gores GJ, Ishii H. The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes. HEPATOLOGY 2001;34:320-328.
18. Yacoub LK, Fogt F, Griniuviene B, Nanji AA. Apoptosis and bcl-2 protein expression in experimental alcoholic liver disease in the rat. Alcohol Clin Exp Res 1995;19:854-859.
19. Ronis MJ, Butura A, Sampey BP, Shankar K, Prior RL, Korourian S, et al. Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition. Free Radic Biol Med 2005;39:619-630.
20. Sadrzadeh SM, Meydani M, Khettry U, Nanji AA. High-dose vitamin E supplementation has no effect on ethanol-induced pathological liver injury. J Pharmacol Exp Ther 1995;273:455-460.
21. Pritchard MT, McMullen MR, Stavitsky AB, Cohen JI, Lin F, Medof ME, et al. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology 2007;132:1117-1126.
22. Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. HEPATOLOGY 2006;44:27-33.
23. Pritchard MT, Roychowdhury S, McMullen MR, Guo L, Arteel GE, Nagy LE. Early growth response-1 contributes to galactosamine/ lipopolysaccharide-induced acute liver injury in mice. Am J Physiol Gastrointest Liver Physiol 2007;293:G1124-G1133.
24. Wu D, Cederbaum AI. Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: Role of CYP2E1 and mitochondria. HEPATOLOGY 2002;35:1420-1430.
25. Jacobsen DW, Gatautis VJ, Green R, Robinson K, Savon SR, Secic M, et al. Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: Sex differences and correlation with cobalamin and folate concentrations in healthy subjects. Clin Chem 1994;40:873-881.
26. Nagy LE. Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp Biol Med (Maywood) 2003; 228:882-890.
27. Pastorino JG, Shulga N, Hoek JB. TNF-alpha-induced cell death in ethanol-exposed cells depends on p38 MAPK signaling but is independent of Bid and caspase-8. Am J Physiol Gastrointest Liver Physiol 2003;285: G503-G516.
28. Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003;112:91-100.
29. Lieber CS. Alcoholic liver disease: New insights in pathogenesis lead to new treatments. J Hepatol 2000;32:113-128.
30. Colell A, Garcia-Ruiz C, Miranda M, Ardite E, Mari M, Morales A, et al. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 1998;115:1541-1551.
31. Leppa S, Pirkkala L, Chow SC, Eriksson JE, Sistonen L. Thioredoxin is transcriptionally induced upon activation of heat shock factor 2. J Biol Chem 1997;272:30400-30404.
32. Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon RG, Smith MA. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J Neurochem 1997;68:2092-2097.
33. Carbone DL, Doorn JA, Petersen DR. 4-Hydroxynonenal regulates 26S proteasomal degradation of alcohol dehydrogenase. Free Radic Biol Med 2004;37:1430-1439.
34. de Villiers WJ, Song Z, Nasser MS, Deaciuc IV, McClain CJ. 4-Hydroxynonenal-induced apoptosis in rat hepatic stellate cells: mechanistic approach. J Gastroenterol Hepatol 2007;22:414-422.
35. Kaplan P, Tatarkova Z, Racay P, Lehotsky J, Pavlikova M, Dobrota D. Oxidative modifications of cardiac mitochondria and inhibition of cytochrome c oxidase activity by 4-hydroxynonenal. Redox Rep 2007;12:211-218.
36. Holmgren A, Bjornstedt M. Thioredoxin and thioredoxin reductase. Methods Enzymol 1995;252:199-208.
37. Hashimoto S, Matsumoto K, Gon Y, Furuichi S, Maruoka S, Takeshita I, et al. Thioredoxin negatively regulates p38MAPkinase activation and IL-6 production by tumor necrosis factor-alpha. Biochem Biophys Res Commun 1999;258:443-447.
38. Kirillova I, Chaisson M, Fausto N. Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor kappaB activation. Cell Growth Differ 1999;10:819-828.
39. Yamada Y, Kirillova I, Peschon JJ, Fausto N. Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci U S A 1997;94:1441-1446.
40. Harada C, Nakamura K, Namekata K, Okumura A, Mitamura Y, Iizuka Y, et al. Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. Am J Pathol 2006;168:261-269.
41. McVicker BL, Tuma DJ, Kubik JL, Tuma PL, Casey CA. Ethanol-induced apoptosis in polarized hepatic cells possibly through regulation of the Fas pathway. Alcohol Clin Exp Res 2006;30:1906-1915.
42. Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 2003;124:1488-1499.
43. Zhou Z, Liu J, Song Z, McClain CJ, Kang YJ. Zinc supplementation inhibits hepatic apoptosis in mice subjected to a long-term ethanol exposure. Exp Biol Med (Maywood) 2008;233:540-548.
44. Lambert JC, Zhou Z, Wang L, Song Z, McClain CJ, Kang YJ. Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated mice. Am J Pathol 2004;164:1959-1966.
45. Crabb DW, Galli A, Fischer M, You M. Molecular mechanisms of alcoholic fatty liver: Role of peroxisome proliferator-activated receptor alpha. Alcohol 2004;34:35-38.
46. Wang JH, Subeq YM, Tsai WC, Lee RP, Hsu BG. Intravenous N-acetylcysteine with saline hydration improves renal function and ameliorates plasma total homocysteine in patients undergoing cardiac angiography. Ren Fail 2008;30:527-533.
47. Yilmaz H, Sahin S, Sayar N, Tangurek B, Yilmaz M, Nurkalem Z, et al. Effects of folic acid and N-acetylcysteine on plasma homocysteine levels and endothelial function in patients with coronary artery disease. Acta Cardiol 2007;62:579-585.
48. Song Z, Zhou Z, Chen T, Hill D, Kang J, Barve S, et al. S-adenosylmethionine (SAMe) protects against acute alcohol induced hepatotoxicity in mice. J Nutr Biochem 2003;14:591-597.
49. Sykora P, Kharbanda KK, Crumm SE, Cahill A. S-Adenosyl-L-methionine co-administration prevents the ethanol-elicited dissociation of hepatic mitochondrial ribosomes in male rats. Alcohol Clin Exp Res 2009;33:1-9.
50. Mato JM, Lu SC. Role of S-adenosyl-L-methionine in liver health and injury. HEPATOLOGY 2007;45:1306-1312.