5-Hydroxy-7-methoxyflavone triggers mitochondrial-associated cell death via reactive oxygen species signaling in human colon carcinoma cells

PLoS ONE

Volumn 11, Issue 4, 2016, Pages

  Bhardwaj, Monika ^a   Kim, Na Hyung ^b   Paul, Souren ^a   Jakhar, Rekha ^a   Han, Jaehong ^c   Kang, Sun Chul ^a  

^a Daegu University   (South Korea)

^b Wonkwang University   (South Korea)

^c Chung Ang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CALCIUM ION; CASPASE 3; CYTOCHROME C; LACTATE DEHYDROGENASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN IRE1; PROTEIN IRE1 ALPHA; REACTIVE OXYGEN METABOLITE; RNA; STRESS ACTIVATED PROTEIN KINASE; TECTOCHRYSIN; UNCLASSIFIED DRUG; 5-HYDROXY-7-METHOXYFLAVONE; ANTINEOPLASTIC AGENT; FLAVONOID;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CARCINOMA CELL; CELL SURVIVAL; COLON CARCINOMA; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME PHOSPHORYLATION; HCT116 CELL LINE; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; COLONIC NEOPLASMS; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; HCT 116 CELL LINE; METABOLISM;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL SURVIVAL; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84977645349     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0154525     Document Type: Article

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