Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

Cell Metabolism

Volumn 24, Issue 3, 2016, Pages 447-461

  Xue, Xiang ^a   Ramakrishnan, Sadeesh K ^a   Weisz, Kevin ^a   Triner, Daniel ^a   Xie, Liwei ^a   Attili, Durga ^b   Pant, Asha ^b   Győrffy, Balázs ^c,d   Zhan, Mingkun ^e   Carter Su, Christin ^a,b   Hardiman, Karin M ^b   Wang, Thomas D ^a,b   Dame, Michael K ^b   Varani, James ^b   Brenner, Dean ^b   Fearon, Eric R ^b   Shah, Yatrik M ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d SEMMELWEIS UNIVERSITY   (Hungary)

^e FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACONITATE HYDRATASE; CYTOCHROME B; FERRITIN; FERROPORTIN; HEMOJUVELIN; HEPCIDIN; HEPHAESTIN; HYPOXIA INDUCIBLE FACTOR 2ALPHA; IRON; IRON REGULATORY FACTOR; JANUS KINASE; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; STAT3 PROTEIN; TRANSFERRIN RECEPTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CATION TRANSPORT PROTEIN; CYCLIN DEPENDENT KINASE 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; SOLUTE CARRIER FAMILY 11- (PROTON-COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2;

ARTICLE; CARCINOGENESIS; CELL CYCLE; CELL PROLIFERATION; COLITIS; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; GENE MUTATION; HUMAN; IRON TRANSPORT; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR VOLUME; COLON; COLORECTAL TUMOR; COMPLICATION; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; HCT 116 CELL LINE; INFLAMMATION; METABOLISM; PATHOLOGY;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARCINOGENESIS; CATION TRANSPORT PROTEINS; CDC2 PROTEIN KINASE; CELL CYCLE; CELL PROLIFERATION; COLITIS; COLON; COLORECTAL NEOPLASMS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; INFLAMMATION; IRON; JANUS KINASES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84990848528     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.07.015     Document Type: Article

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