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Volumn 34, Issue 1, 2013, Pages 163-169

Hypoxia-inducible factor-2α is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 2ALPHA; NIMESULIDE; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E1; PROSTAGLANDIN E2; VON HIPPEL LINDAU PROTEIN;

EID: 84872130484     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgs313     Document Type: Article
Times cited : (64)

References (56)
  • 1
    • 0027993458 scopus 로고
    • Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
    • Eberhart, C.E. et al. (1994) Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology, 107, 1183-1188.
    • (1994) Gastroenterology , vol.107 , pp. 1183-1188
    • Eberhart, C.E.1
  • 2
    • 0033594963 scopus 로고    scopus 로고
    • Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
    • Jakobsson, P.J. et al. (1999) Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acad. Sci. U.S.A., 96, 7220-7225.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 7220-7225
    • Jakobsson, P.J.1
  • 3
    • 33645968137 scopus 로고    scopus 로고
    • Prostaglandin E synthase: a novel drug target for inflammation and cancer
    • Murakami, M. et al. (2006) Prostaglandin E synthase: a novel drug target for inflammation and cancer. Curr. Pharm. Des., 12, 943-954.
    • (2006) Curr. Pharm. Des. , vol.12 , pp. 943-954
    • Murakami, M.1
  • 4
    • 17744418769 scopus 로고    scopus 로고
    • The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
    • Steinbach, G. et al. (2000) The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N. Engl. J. Med., 342, 1946-1952.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1946-1952
    • Steinbach, G.1
  • 5
    • 0031034814 scopus 로고    scopus 로고
    • Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells
    • Schmedtje, J.F. Jr et al. (1997) Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J. Biol. Chem., 272, 601-608.
    • (1997) J. Biol. Chem. , vol.272 , pp. 601-608
    • Schmedtje Jr., J.F.1
  • 6
    • 31544467810 scopus 로고    scopus 로고
    • Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1alpha in non-small cell lung cancer
    • Csiki, I. et al. (2006) Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1alpha in non-small cell lung cancer. Cancer Res., 66, 143-150.
    • (2006) Cancer Res , vol.66 , pp. 143-150
    • Csiki, I.1
  • 7
    • 33746123520 scopus 로고    scopus 로고
    • Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia
    • Kaidi, A. et al. (2006) Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. Cancer Res., 66, 6683-6691.
    • (2006) Cancer Res , vol.66 , pp. 6683-6691
    • Kaidi, A.1
  • 8
    • 79951829343 scopus 로고    scopus 로고
    • Hypoxia and inflammation
    • Eltzschig, H.K. et al. (2011) Hypoxia and inflammation. N. Engl. J. Med., 364, 656-665.
    • (2011) N. Engl. J. Med. , vol.364 , pp. 656-665
    • Eltzschig, H.K.1
  • 9
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout, J.A. et al. (2008) The impact of O2 availability on human cancer. Nat. Rev. Cancer, 8, 967-975.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1
  • 10
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza, G.L. et al. (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol., 12, 5447-5454.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5447-5454
    • Semenza, G.L.1
  • 11
    • 0027427588 scopus 로고
    • Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
    • Wang, G.L. et al. (1993) Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem., 268, 21513-21518.
    • (1993) J. Biol. Chem. , vol.268 , pp. 21513-21518
    • Wang, G.L.1
  • 12
    • 0035917313 scopus 로고    scopus 로고
    • HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
    • Ivan, M. et al. (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science, 292, 464-468.
    • (2001) Science , vol.292 , pp. 464-468
    • Ivan, M.1
  • 13
    • 0035917808 scopus 로고    scopus 로고
    • Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    • Jaakkola, P. et al. (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science, 292, 468-472.
    • (2001) Science , vol.292 , pp. 468-472
    • Jaakkola, P.1
  • 14
    • 0027210562 scopus 로고
    • General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
    • Wang, G.L. et al. (1993) General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc. Natl. Acad. Sci. U.S.A., 90, 4304-4308.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 4304-4308
    • Wang, G.L.1
  • 15
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang, G.L. (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. U.S.A., 92, 5510-5514.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 5510-5514
    • Wang, G.L.1
  • 16
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian, H. et al. (1997) Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev., 11, 72-82.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1
  • 17
    • 78349272461 scopus 로고    scopus 로고
    • HIF-1 and HIF-2 transcription factors-similar but not identical
    • Loboda, A. et al. (2010) HIF-1 and HIF-2 transcription factors-similar but not identical. Mol. Cells, 29, 435-442.
    • (2010) Mol. Cells , vol.29 , pp. 435-442
    • Loboda, A.1
  • 18
    • 84860520642 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis
    • Xue, X. et al. (2012) Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Res., 72, 2285-2293.
    • (2012) Cancer Res , vol.72 , pp. 2285-2293
    • Xue, X.1
  • 19
    • 58749094789 scopus 로고    scopus 로고
    • Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency
    • Shah, Y.M. et al. (2009) Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metab., 9, 152-164.
    • (2009) Cell Metab , vol.9 , pp. 152-164
    • Shah, Y.M.1
  • 20
    • 0035852668 scopus 로고    scopus 로고
    • Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
    • Haase, V.H. et al. (2001) Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc. Natl. Acad. Sci. U.S.A., 98, 1583-1588.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 1583-1588
    • Haase, V.H.1
  • 21
    • 79958146087 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice
    • Taylor, M. et al. (2011) Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology, 140, 2044-2055.
    • (2011) Gastroenterology , vol.140 , pp. 2044-2055
    • Taylor, M.1
  • 22
    • 0033582253 scopus 로고    scopus 로고
    • Glucocorticoid-mediated suppression of the promoter activity of the cyclooxygenase-2 gene is modulated by expression of its receptor in vascular endothelial cells
    • Inoue, H. et al. (1999) Glucocorticoid-mediated suppression of the promoter activity of the cyclooxygenase-2 gene is modulated by expression of its receptor in vascular endothelial cells. Biochem. Biophys. Res. Commun., 254, 292-298.
    • (1999) Biochem. Biophys. Res. Commun. , vol.254 , pp. 292-298
    • Inoue, H.1
  • 23
    • 0029858387 scopus 로고    scopus 로고
    • TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB
    • Wang, C.Y. et al. (1996) TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science, 274, 784-787.
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.Y.1
  • 24
    • 18444408375 scopus 로고    scopus 로고
    • COX-2: a molecular target for colorectal cancer prevention
    • Brown, J.R. et al. (2005) COX-2: a molecular target for colorectal cancer prevention. J. Clin. Oncol., 23, 2840-2855.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2840-2855
    • Brown, J.R.1
  • 25
    • 77950888839 scopus 로고    scopus 로고
    • Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis
    • Lee, J.J. et al. (2010) Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis. Carcinogenesis, 31, 427-434.
    • (2010) Carcinogenesis , vol.31 , pp. 427-434
    • Lee, J.J.1
  • 26
    • 0033530260 scopus 로고    scopus 로고
    • The relationship between cyclooxygenase-2 expression and colorectal cancer
    • Sheehan, K.M. et al. (1999) The relationship between cyclooxygenase-2 expression and colorectal cancer. JAMA, 282, 1254-1257.
    • (1999) JAMA , vol.282 , pp. 1254-1257
    • Sheehan, K.M.1
  • 27
    • 79957947446 scopus 로고    scopus 로고
    • The interplay between indoleamine 2 3-dioxygenase 1 (IDO1) and cyclooxygenase (COX)-2 in chronic inflammation and cancer
    • Cesario, A. et al. (2011) The interplay between indoleamine 2, 3-dioxygenase 1 (IDO1) and cyclooxygenase (COX)-2 in chronic inflammation and cancer. Curr. Med. Chem., 18, 2263-2271.
    • (2011) Curr. Med. Chem. , vol.18 , pp. 2263-2271
    • Cesario, A.1
  • 28
    • 0142137237 scopus 로고    scopus 로고
    • Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2 3-dioxygenase
    • Uyttenhove, C. et al. (2003) Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2, 3-dioxygenase. Nat. Med., 9, 1269-1274.
    • (2003) Nat. Med. , vol.9 , pp. 1269-1274
    • Uyttenhove, C.1
  • 29
    • 16244408626 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2, 3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
    • Muller, A.J. et al. (2005) Inhibition of indoleamine 2, 3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat. Med., 11, 312-319.
    • (2005) Nat. Med. , vol.11 , pp. 312-319
    • Muller, A.J.1
  • 30
    • 59849121138 scopus 로고    scopus 로고
    • Progression of pancreatic adenocarcinoma is significantly impeded with a combination of vaccine and COX-2 inhibition
    • Mukherjee, P. et al. (2009) Progression of pancreatic adenocarcinoma is significantly impeded with a combination of vaccine and COX-2 inhibition. J. Immunol., 182, 216-224.
    • (2009) J. Immunol. , vol.182 , pp. 216-224
    • Mukherjee, P.1
  • 31
    • 76649088968 scopus 로고    scopus 로고
    • Hydroxyamidine inhibitors of indoleamine-2 3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors
    • Koblish, H.K. et al. (2010) Hydroxyamidine inhibitors of indoleamine-2, 3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors. Mol. Cancer Ther., 9, 489-498.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 489-498
    • Koblish, H.K.1
  • 32
    • 33846689594 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2 3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses
    • Hou, D.Y. et al. (2007) Inhibition of indoleamine 2, 3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. Cancer Res., 67, 792-801.
    • (2007) Cancer Res , vol.67 , pp. 792-801
    • Hou, D.Y.1
  • 33
    • 77649179672 scopus 로고    scopus 로고
    • Eicosanoids and cancer
    • Wang, D. et al. (2010) Eicosanoids and cancer. Nat. Rev. Cancer, 10, 181-193.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 181-193
    • Wang, D.1
  • 34
    • 0036169389 scopus 로고    scopus 로고
    • COX-2: a target for colon cancer prevention
    • Marnett, L.J. et al. (2002) COX-2: a target for colon cancer prevention. Annu. Rev. Pharmacol. Toxicol., 42, 55-80.
    • (2002) Annu. Rev. Pharmacol. Toxicol. , vol.42 , pp. 55-80
    • Marnett, L.J.1
  • 35
    • 0035207130 scopus 로고    scopus 로고
    • Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer
    • Cianchi, F. et al. (2001) Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. Gastroenterology, 121, 1339-1347.
    • (2001) Gastroenterology , vol.121 , pp. 1339-1347
    • Cianchi, F.1
  • 36
    • 0029117472 scopus 로고
    • Expression of cyclooxygenase-1 and -2 in human colorectal cancer
    • Sano, H. et al. (1995) Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res., 55, 3785-3789.
    • (1995) Cancer Res , vol.55 , pp. 3785-3789
    • Sano, H.1
  • 37
    • 0032694425 scopus 로고    scopus 로고
    • Differential expression of cyclooxygenase 2 in human colorectal cancer
    • Dimberg, J. et al. (1999) Differential expression of cyclooxygenase 2 in human colorectal cancer. Gut, 45, 730-732.
    • (1999) Gut , vol.45 , pp. 730-732
    • Dimberg, J.1
  • 38
    • 57349118495 scopus 로고    scopus 로고
    • Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression
    • Al-Salihi, M.A. et al. (2009) Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression. Cancer Lett., 273, 225-232.
    • (2009) Cancer Lett , vol.273 , pp. 225-232
    • Al-Salihi, M.A.1
  • 39
    • 0030606299 scopus 로고    scopus 로고
    • Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
    • Oshima, M. et al. (1996) Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell, 87, 803-809.
    • (1996) Cell , vol.87 , pp. 803-809
    • Oshima, M.1
  • 40
    • 0034282465 scopus 로고    scopus 로고
    • Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice
    • Chulada, P.C. et al. (2000) Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res., 60, 4705-4708.
    • (2000) Cancer Res , vol.60 , pp. 4705-4708
    • Chulada, P.C.1
  • 41
    • 0038482089 scopus 로고    scopus 로고
    • Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis
    • Kamei, D. et al. (2003) Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. J. Biol. Chem., 278, 19396-19405.
    • (2003) J. Biol. Chem. , vol.278 , pp. 19396-19405
    • Kamei, D.1
  • 42
    • 0035674730 scopus 로고    scopus 로고
    • Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer
    • Yoshimatsu, K. et al. (2001) Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. Clin. Cancer Res., 7, 3971-3976.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3971-3976
    • Yoshimatsu, K.1
  • 43
    • 84862331459 scopus 로고    scopus 로고
    • Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis
    • Sasaki, Y. et al. (2012) Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis. Oncogene, 31, 2943-2952.
    • (2012) Oncogene , vol.31 , pp. 2943-2952
    • Sasaki, Y.1
  • 44
    • 44849085464 scopus 로고    scopus 로고
    • Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis
    • Nakanishi, M. et al. (2008) Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis. Cancer Res., 68, 3251-3259.
    • (2008) Cancer Res , vol.68 , pp. 3251-3259
    • Nakanishi, M.1
  • 45
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    • Gordan, J.D. et al. (2007) HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell, 11, 335-347.
    • (2007) Cancer Cell , vol.11 , pp. 335-347
    • Gordan, J.D.1
  • 46
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxiainducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • Talks, K.L. et al. (2000) The expression and distribution of the hypoxiainducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol., 157, 411-421.
    • (2000) Am. J. Pathol. , vol.157 , pp. 411-421
    • Talks, K.L.1
  • 47
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • Zhong, H. et al. (1999) Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res., 59, 5830-5835.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1
  • 48
    • 0027371123 scopus 로고
    • Altered eicosanoid levels in human colon cancer
    • Rigas, B. et al. (1993) Altered eicosanoid levels in human colon cancer. J. Lab. Clin. Med., 122, 518-523.
    • (1993) J. Lab. Clin. Med. , vol.122 , pp. 518-523
    • Rigas, B.1
  • 49
    • 84856748026 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes intestinal tumor growth via DNA methylation
    • Xia, D. et al. (2012) Prostaglandin E2 promotes intestinal tumor growth via DNA methylation. Nat. Med., 18, 224-226.
    • (2012) Nat. Med. , vol.18 , pp. 224-226
    • Xia, D.1
  • 50
    • 0037081178 scopus 로고    scopus 로고
    • Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice
    • Hansen-Petrik, M.B. et al. (2002) Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice. Cancer Res., 62, 403-408.
    • (2002) Cancer Res , vol.62 , pp. 403-408
    • Hansen-Petrik, M.B.1
  • 51
    • 37149052447 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes
    • Grimmer, C. et al. (2007) Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes. Arthritis Rheum., 56, 4084-4094.
    • (2007) Arthritis Rheum , vol.56 , pp. 4084-4094
    • Grimmer, C.1
  • 52
    • 0034707105 scopus 로고    scopus 로고
    • Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis
    • Vigor Study Group
    • Bombardier, C. et al.; VIGOR Study Group. (2000) Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N. Engl. J. Med., 343, 1520-8, 2 p following 1528.
    • (2000) VIGOR Study Group. N. Engl. J. Med. , vol.343 , pp. 1520-1528
    • Bombardier, C.1
  • 53
    • 14944342151 scopus 로고    scopus 로고
    • COX-2 inhibitors-a lesson in unexpected problems
    • Drazen, J.M. (2005) COX-2 inhibitors-a lesson in unexpected problems. N. Engl. J. Med., 352, 1131-1132.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 1131-1132
    • Drazen, J.M.1
  • 54
    • 84862287785 scopus 로고    scopus 로고
    • Physiology. COX-2 inhibitors and cardiovascular risk
    • Cannon, C.P. et al. (2012) Physiology. COX-2 inhibitors and cardiovascular risk. Science, 336, 1386-1387.
    • (2012) Science , vol.336 , pp. 1386-1387
    • Cannon, C.P.1
  • 55
    • 80054927472 scopus 로고    scopus 로고
    • Identification and development of mPGES-1 inhibitors: where we are at?
    • Chang, H.H. et al. (2011) Identification and development of mPGES-1 inhibitors: where we are at? Future Med. Chem., 3, 1909-1934.
    • (2011) Future Med. Chem , vol.3 , pp. 1909-1934
    • Chang, H.H.1
  • 56
    • 84555169343 scopus 로고    scopus 로고
    • Molecular docking and competitive binding study discovered different binding modes of microsomal prostaglandin E synthase-1 inhibitors
    • He, S. et al. (2011) Molecular docking and competitive binding study discovered different binding modes of microsomal prostaglandin E synthase-1 inhibitors. J. Chem. Inf. Model., 51, 3254-3261. L. Idhayavani
    • (2011) J. Chem. Inf. Model. , vol.51 , pp. 3254-3261
    • He, S.1


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