-
1
-
-
70349297213
-
The treatment of secondary hemochromatosis
-
Gattermann N (2009) The treatment of secondary hemochromatosis. Dtsch Arztebl Int 106(30):499-504, I.
-
(2009)
Dtsch Arztebl Int
, vol.106
, Issue.30
-
-
Gattermann, N.1
-
2
-
-
80455143324
-
Elevated liver iron concentration is a marker of increased morbidity in patients with β thalassemia intermedia
-
Musallam KM, et al. (2011) Elevated liver iron concentration is a marker of increased morbidity in patients with β thalassemia intermedia. Haematologica 96(11):1605-1612.
-
(2011)
Haematologica
, vol.96
, Issue.11
, pp. 1605-1612
-
-
Musallam, K.M.1
-
3
-
-
0004252202
-
-
Cambridge Univ Press, Cambridge, UK
-
Steinberg MHFB, Higgs DR, Nagel RL (2001) Disorders of Hemoglobin: Genetics, Pathophysiology and Clincal Management (Cambridge Univ Press, Cambridge, UK).
-
(2001)
Disorders of Hemoglobin: Genetics, Pathophysiology and Clincal Management
-
-
Steinberg, M.H.F.B.1
Higgs, D.R.2
Nagel, R.L.3
-
4
-
-
0015783837
-
Absorption of inorganic and food iron in children with heterozygous and homozygous beta-thalassemia
-
Heinrich HC, et al. (1973) Absorption of inorganic and food iron in children with heterozygous and homozygous beta-thalassemia. Z Kinderheilkd 115(1):1-22.
-
(1973)
Z Kinderheilkd
, vol.115
, Issue.1
, pp. 1-22
-
-
Heinrich, H.C.1
-
5
-
-
0013811581
-
The measurement of iron absorption by the double isotope technique
-
Pitcher CS, Williams HS, Parsonson A, Williams R (1965) The measurement of iron absorption by the double isotope technique. Br J Haematol 11(6):633-641.
-
(1965)
Br J Haematol
, vol.11
, Issue.6
, pp. 633-641
-
-
Pitcher, C.S.1
Williams, H.S.2
Parsonson, A.3
Williams, R.4
-
6
-
-
80054838641
-
β-thalassemia: A model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism
-
Ginzburg Y, Rivella S (2011) β-thalassemia: A model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood 118(16):4321-4330.
-
(2011)
Blood
, vol.118
, Issue.16
, pp. 4321-4330
-
-
Ginzburg, Y.1
Rivella, S.2
-
7
-
-
0035902605
-
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
-
Nicolas G, et al. (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 98(15):8780-8785.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.15
, pp. 8780-8785
-
-
Nicolas, G.1
-
8
-
-
0037007064
-
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
-
Nicolas G, et al. (2002) Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 99(7):4596-4601.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.7
, pp. 4596-4601
-
-
Nicolas, G.1
-
9
-
-
0034733635
-
A novel mammalian iron-regulated protein involved in intracellular iron metabolism
-
Abboud S, Haile DJ (2000) A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275(26):19906-19912.
-
(2000)
J Biol Chem
, vol.275
, Issue.26
, pp. 19906-19912
-
-
Abboud, S.1
Haile, D.J.2
-
10
-
-
0034677467
-
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
-
Donovan A, et al. (2000) Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403(6771):776-781.
-
(2000)
Nature
, vol.403
, Issue.6771
, pp. 776-781
-
-
Donovan, A.1
-
11
-
-
20444416123
-
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
-
Donovan A, et al. (2005) The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 1(3):191-200.
-
(2005)
Cell Metab
, vol.1
, Issue.3
, pp. 191-200
-
-
Donovan, A.1
-
12
-
-
0033861745
-
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
-
McKie AT, et al. (2000) A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5(2):299-309.
-
(2000)
Mol Cell
, vol.5
, Issue.2
, pp. 299-309
-
-
McKie, A.T.1
-
13
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
Nemeth E, et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306(5704):2090-2093.
-
(2004)
Science
, vol.306
, Issue.5704
, pp. 2090-2093
-
-
Nemeth, E.1
-
14
-
-
13444252281
-
Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 over-expression and down-regulated by hepcidin
-
Knutson MD, Oukka M, Koss LM, Aydemir F, Wessling-Resnick M (2005) Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 over-expression and down-regulated by hepcidin. Proc Natl Acad Sci USA 102(5):1324-1328.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.5
, pp. 1324-1328
-
-
Knutson, M.D.1
Oukka, M.2
Koss, L.M.3
Aydemir, F.4
Wessling-Resnick, M.5
-
15
-
-
0036727925
-
Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
-
Frazer DM, et al. (2002) Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 123(3):835-844.
-
(2002)
Gastroenterology
, vol.123
, Issue.3
, pp. 835-844
-
-
Frazer, D.M.1
-
16
-
-
0346433908
-
Decreased hepcidin mRNA expression in thalassemic mice
-
Adamsky K, et al. (2004) Decreased hepcidin mRNA expression in thalassemic mice. Br J Haematol 124(1):123-124.
-
(2004)
Br J Haematol
, vol.124
, Issue.1
, pp. 123-124
-
-
Adamsky, K.1
-
18
-
-
84879458253
-
Iron homeostasis in the liver
-
Anderson ER, Shah YM (2013) Iron homeostasis in the liver. Compr Physiol 3(1):315-330.
-
(2013)
Compr Physiol
, vol.3
, Issue.1
, pp. 315-330
-
-
Anderson, E.R.1
Shah, Y.M.2
-
19
-
-
34948904750
-
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
-
Tanno T, et al. (2007) High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med 13(9):1096-1101.
-
(2007)
Nat Med
, vol.13
, Issue.9
, pp. 1096-1101
-
-
Tanno, T.1
-
20
-
-
67651043722
-
Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells
-
Tanno T, et al. (2009) Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood 114(1):181-186.
-
(2009)
Blood
, vol.114
, Issue.1
, pp. 181-186
-
-
Tanno, T.1
-
21
-
-
78649813036
-
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice
-
Gardenghi S, et al. (2010) Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. J Clin Invest 120(12):4466-4477.
-
(2010)
J Clin Invest
, vol.120
, Issue.12
, pp. 4466-4477
-
-
Gardenghi, S.1
-
22
-
-
84875849962
-
Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice
-
Guo S, et al. (2013) Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice. J Clin Invest 123(4):1531-1541.
-
(2013)
J Clin Invest
, vol.123
, Issue.4
, pp. 1531-1541
-
-
Guo, S.1
-
23
-
-
84874066920
-
An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia
-
Schmidt PJ, et al. (2013) An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia. Blood 121(7):1200-1208.
-
(2013)
Blood
, vol.121
, Issue.7
, pp. 1200-1208
-
-
Schmidt, P.J.1
-
24
-
-
84860520642
-
Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis
-
Xue X, et al. (2012) Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Res 72(9):2285-2293.
-
(2012)
Cancer Res
, vol.72
, Issue.9
, pp. 2285-2293
-
-
Xue, X.1
-
25
-
-
79958146087
-
Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice
-
Taylor M, et al. (2011) Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology 140(7):2044-2055.
-
(2011)
Gastroenterology
, vol.140
, Issue.7
, pp. 2044-2055
-
-
Taylor, M.1
-
26
-
-
58749094789
-
Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency
-
Shah YM, Matsubara T, Ito S, Yim SH, Gonzalez FJ (2009) Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metab 9(2):152-164.
-
(2009)
Cell Metab
, vol.9
, Issue.2
, pp. 152-164
-
-
Shah, Y.M.1
Matsubara, T.2
Ito, S.3
Yim, S.H.4
Gonzalez, F.J.5
-
27
-
-
79957616004
-
Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis
-
Anderson ER, Xue X, Shah YM (2011) Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis. J Biol Chem 286(22):19533-19540.
-
(2011)
J Biol Chem
, vol.286
, Issue.22
, pp. 19533-19540
-
-
Anderson, E.R.1
Xue, X.2
Shah, Y.M.3
-
28
-
-
84855856999
-
Deletion of HIF-2α in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice
-
Mastrogiannaki M, et al. (2012) Deletion of HIF-2α in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice. Blood 119(2):587-590.
-
(2012)
Blood
, vol.119
, Issue.2
, pp. 587-590
-
-
Mastrogiannaki, M.1
-
29
-
-
66449124596
-
HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice
-
Mastrogiannaki M, et al. (2009) HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J Clin Invest 119(5):1159-1166.
-
(2009)
J Clin Invest
, vol.119
, Issue.5
, pp. 1159-1166
-
-
Mastrogiannaki, M.1
-
30
-
-
78649364332
-
Hypoxia-inducible factors and the response to hypoxic stress
-
Majmundar AJ, Wong WJ, Simon MC (2010) Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell 40(2):294-309.
-
(2010)
Mol Cell
, vol.40
, Issue.2
, pp. 294-309
-
-
Majmundar, A.J.1
Wong, W.J.2
Simon, M.C.3
-
31
-
-
28544443846
-
Iron Imports. II. Iron uptake at the apical membrane in the intestine
-
Mackenzie B, Garrick MD (2005) Iron Imports. II. Iron uptake at the apical membrane in the intestine. Am J Physiol Gastrointest Liver Physiol 289(6):G981-G986.
-
(2005)
Am J Physiol Gastrointest Liver Physiol
, vol.289
, Issue.6
-
-
Mackenzie, B.1
Garrick, M.D.2
-
32
-
-
44449108683
-
Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells
-
Latunde-Dada GO, Simpson RJ, McKie AT (2008) Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells. J Nutr 138(6):991-995.
-
(2008)
J Nutr
, vol.138
, Issue.6
, pp. 991-995
-
-
Latunde-Dada, G.O.1
Simpson, R.J.2
McKie, A.T.3
-
33
-
-
0035793856
-
An iron-regulated ferric reductase associated with the absorption of dietary iron
-
McKie AT, et al. (2001) An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 291(5509):1755-1759.
-
(2001)
Science
, vol.291
, Issue.5509
, pp. 1755-1759
-
-
McKie, A.T.1
-
34
-
-
0030763856
-
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
-
Fleming MD, et al. (1997) Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16(4):383-386.
-
(1997)
Nat Genet
, vol.16
, Issue.4
, pp. 383-386
-
-
Fleming, M.D.1
-
35
-
-
0030755366
-
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
-
Gunshin H, et al. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388(6641):482-488.
-
(1997)
Nature
, vol.388
, Issue.6641
, pp. 482-488
-
-
Gunshin, H.1
-
36
-
-
0037606048
-
A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer
-
Rivella S, May C, Chadburn A, Rivière I, Sadelain M (2003) A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer. Blood 101(8):2932-2939.
-
(2003)
Blood
, vol.101
, Issue.8
, pp. 2932-2939
-
-
Rivella, S.1
May, C.2
Chadburn, A.3
Rivière, I.4
Sadelain, M.5
-
37
-
-
0029045603
-
Mouse model of human beta zero thalassemia: Targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells
-
Ciavatta DJ, Ryan TM, Farmer SC, Townes TM (1995) Mouse model of human beta zero thalassemia: Targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells. Proc Natl Acad Sci USA 92(20):9259-9263.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.20
, pp. 9259-9263
-
-
Ciavatta, D.J.1
Ryan, T.M.2
Farmer, S.C.3
Townes, T.M.4
-
38
-
-
0029589914
-
A mouse model for beta 0-thalassemia
-
Yang B, et al. (1995) A mouse model for beta 0-thalassemia. Proc Natl Acad Sci USA 92 (25):11608-11612.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.25
, pp. 11608-11612
-
-
Yang, B.1
-
39
-
-
59249095557
-
Regulation of iron absorption in hemoglobinopathies
-
Rechavi G, Rivella S (2008) Regulation of iron absorption in hemoglobinopathies. Curr Mol Med 8(7):646-662.
-
(2008)
Curr Mol Med
, vol.8
, Issue.7
, pp. 646-662
-
-
Rechavi, G.1
Rivella, S.2
-
40
-
-
84868676833
-
The hypoxia-inducible factor-C/EBṔ axis controls ethanol-mediated hepcidin repression
-
Anderson ER, et al. (2012) The hypoxia-inducible factor-C/EBṔ axis controls ethanol-mediated hepcidin repression. Mol Cell Biol 32(19):4068-4077.
-
(2012)
Mol Cell Biol
, vol.32
, Issue.19
, pp. 4068-4077
-
-
Anderson, E.R.1
-
41
-
-
34447306076
-
Liver iron concentrations and urinary hepcidin in beta-thalassemia
-
Origa R, et al. (2007) Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica 92(5):583-588.
-
(2007)
Haematologica
, vol.92
, Issue.5
, pp. 583-588
-
-
Origa, R.1
-
42
-
-
34249658982
-
Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin
-
Gardenghi S, et al. (2007) Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. Blood 109(11):5027-5035.
-
(2007)
Blood
, vol.109
, Issue.11
, pp. 5027-5035
-
-
Gardenghi, S.1
-
43
-
-
80051895753
-
Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses
-
Zhang Z, et al. (2011) Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses. Blood 118(7):1912-1922.
-
(2011)
Blood
, vol.118
, Issue.7
, pp. 1912-1922
-
-
Zhang, Z.1
-
44
-
-
33644772206
-
Animal models with enhanced erythropoiesis and iron absorption
-
Latunde-Dada GO, McKie AT, Simpson RJ (2006) Animal models with enhanced erythropoiesis and iron absorption. Biochim Biophys Acta 1762(4):414-423.
-
(2006)
Biochim Biophys Acta
, vol.1762
, Issue.4
, pp. 414-423
-
-
Latunde-Dada, G.O.1
McKie, A.T.2
Simpson, R.J.3
-
45
-
-
84875443909
-
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
-
Scheuermann TH, et al. (2013) Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol 9(4):271-276.
-
(2013)
Nat Chem Biol
, vol.9
, Issue.4
, pp. 271-276
-
-
Scheuermann, T.H.1
-
46
-
-
72249095193
-
Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B
-
Key J, Scheuermann TH, Anderson PC, Daggett V, Gardner KH (2009) Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B. J Am Chem Soc 131(48):17647-17654.
-
(2009)
J Am Chem Soc
, vol.131
, Issue.48
, pp. 17647-17654
-
-
Key, J.1
Scheuermann, T.H.2
Anderson, P.C.3
Daggett, V.4
Gardner, K.H.5
-
47
-
-
58849141619
-
Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor
-
Scheuermann TH, et al. (2009) Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc Natl Acad Sci USA 106(2):450-455.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.2
, pp. 450-455
-
-
Scheuermann, T.H.1
-
48
-
-
76349118307
-
Transferrin therapy ameliorates disease in beta-thalassemic mice
-
Li H, et al. (2010) Transferrin therapy ameliorates disease in beta-thalassemic mice. Nat Med 16(2):177-182.
-
(2010)
Nat Med
, vol.16
, Issue.2
, pp. 177-182
-
-
Li, H.1
-
50
-
-
84863983904
-
Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors
-
Zhang Z, et al. (2012) Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors. Bioorg Med Chem Lett 22(15):5108-5113.
-
(2012)
Bioorg Med Chem Lett
, vol.22
, Issue.15
, pp. 5108-5113
-
-
Zhang, Z.1
-
51
-
-
18244399587
-
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver
-
Gunshin H, et al. (2005) Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest 115(5):1258-1266.
-
(2005)
J Clin Invest
, vol.115
, Issue.5
, pp. 1258-1266
-
-
Gunshin, H.1
-
52
-
-
4043059169
-
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
-
el Marjou F, et al. (2004) Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39(3):186-193.
-
(2004)
Genesis
, vol.39
, Issue.3
, pp. 186-193
-
-
El Marjou, F.1
|