Fungus-derived neoechinulin B as a novel antagonist of liver X receptor, identified by chemical genetics using a hepatitis C virus cell culture system

Journal of Virology

Volumn 90, Issue 20, 2016, Pages 9058-9074

  Nakajima, Syo ^a,b   Watashi, Koichi ^a,b,c   Ohashi, Hirofumi ^a,b   Kamisuki, Shinji ^b,g   Izaguirre Carbonell, Jesus ^b   Kwon, Andrew Tae Jun ^d   Suzuki, Harukazu ^d   Kataoka, Michiyo ^a   Tsukuda, Senko ^a,d   Okada, Maiko ^e   Moi, Meng Ling ^a,h   Takeuchi, Toshifumi ^f,i   Arita, Minetaro ^a   Suzuki, Ryosuke ^a   Aizaki, Hideki ^a   Kato, Takanobu ^a   Suzuki, Tadaki ^a   Hasegawa, Hideki ^a   Takasaki, Tomohiko ^a   Sugawara, Fumio ^b   Wakita, Takaji ^a   more..

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d RIKEN   (Japan)

^e ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f UNIVERSITY OF CHICAGO   (United States)

^g AZABU UNIVERSITY   (Japan)

^h NAGASAKI UNIVERSITY   (Japan)

ⁱ INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE RECEPTOR BLOCKING AGENT; LIVER X RECEPTOR; LIVER X RECEPTOR ANTAGONIST; NEOECHINULIN B; NONSTRUCTURAL PROTEIN 5A INHIBITOR; UNCLASSIFIED DRUG; ALKALOID; ANTIVIRUS AGENT; NEOECHINULIN; PIPERAZINE DERIVATIVE; PROTEIN BINDING;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; GENETIC ANALYSIS; GENETIC ASSOCIATION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; LIPID METABOLISM; LIVER CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS; VIRUS CELL INTERACTION; VIRUS INFECTIVITY; VIRUS INHIBITION; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CELL CULTURE TECHNIQUE; CELL LINE; CHEMISTRY; DENGUE VIRUS; DRUG DEVELOPMENT; DRUG EFFECTS; FUNGUS; HEPACIVIRUS; ISOLATION AND PURIFICATION; LIVER CELL; METABOLISM; PHYSIOLOGY; POLIOMYELITIS VIRUS; PRECLINICAL STUDY; PROCEDURES; VIROLOGY;

ALKALOIDS; ANTIVIRAL AGENTS; CELL CULTURE TECHNIQUES; CELL LINE; DENGUE VIRUS; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; FUNGI; HEPACIVIRUS; HEPATOCYTES; HUMANS; LIVER X RECEPTORS; PIPERAZINES; POLIOVIRUS; PROTEIN BINDING; VIRUS REPLICATION;

EID: 84990051080     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00856-16     Document Type: Article

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