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Volumn 51, Issue 12, 2010, Pages 3425-3433

Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity

Author keywords

Fatty acid synthesis; Ligand; Liver X receptor

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; FAS ANTIGEN; LIVER X RECEPTOR; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; SMALL INTERFERING RNA; TRIACYLGLYCEROL;

EID: 78650043469     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M007989     Document Type: Article
Times cited : (48)

References (46)
  • 1
    • 0345461478 scopus 로고    scopus 로고
    • Putative metabolic effects of the liver X receptor (LXR)
    • Steffensen, K. R., and J. A. Gustafsson. 2004. Putative metabolic effects of the liver X receptor (LXR). Diabetes. 53 (Suppl. 1): S36-S42.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Steffensen, K.R.1    Gustafsson, J.A.2
  • 3
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
    • Janowski, B. A., P. J. Willy, T. R. Devi, J. R. Falck, and D. J. Mangelsdorf. 1996. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 383: 728-731.
    • (1996) Nature , vol.383 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3    Falck, J.R.4    Mangelsdorf, D.J.5
  • 4
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
    • Peet, D. J., S. D. Turley, W. Ma, B. A. Janowski, J. M. Lobaccaro, R. E. Hammer, and D. J. Mangelsdorf. 1998. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 93: 693-704.
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.M.5    Hammer, R.E.6    Mangelsdorf, D.J.7
  • 5
    • 0036851863 scopus 로고    scopus 로고
    • The liver X receptor gene team: Potential new players in atherosclerosis
    • Repa, J. J., and D. J. Mangelsdorf. 2002. The liver X receptor gene team: potential new players in atherosclerosis. Nat. Med. 8: 1243-1248.
    • (2002) Nat. Med. , vol.8 , pp. 1243-1248
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 7
    • 0037072809 scopus 로고    scopus 로고
    • Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1
    • Plosch, T., T. Kok, V. W. Bloks, M. J. Smit, R. Havinga, G. Chimini, A. K. Groen, and F. Kuipers. 2002. Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. J. Biol. Chem. 277: 33870-33877.
    • (2002) J. Biol. Chem. , vol.277 , pp. 33870-33877
    • Plosch, T.1    Kok, T.2    Bloks, V.W.3    Smit, M.J.4    Havinga, R.5    Chimini, G.6    Groen, A.K.7    Kuipers, F.8
  • 8
    • 3242699720 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of atherosclerosis with mouse models
    • Ohashi, R., H. Mu, Q. Yao, and C. Chen. 2004. Cellular and molecular mechanisms of atherosclerosis with mouse models. Trends Cardiovasc. Med. 14: 187-190.
    • (2004) Trends Cardiovasc. Med. , vol.14 , pp. 187-190
    • Ohashi, R.1    Mu, H.2    Yao, Q.3    Chen, C.4
  • 13
    • 34249682775 scopus 로고    scopus 로고
    • Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: Liver X receptor-mediated lipotoxicity in pancreatic beta-cells
    • Choe, S. S., A. H. Choi, J. W. Lee, K. H. Kim, J. J. Chung, J. Park, K. M. Lee, K. G. Park, I. K. Lee, and J. B. Kim. 2007. Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells. Diabetes. 56: 1534-1543.
    • (2007) Diabetes , vol.56 , pp. 1534-1543
    • Choe, S.S.1    Choi, A.H.2    Lee, J.W.3    Kim, K.H.4    Chung, J.J.5    Park, J.6    Lee, K.M.7    Park, K.G.8    Lee, I.K.9    Kim, J.B.10
  • 15
    • 0037324340 scopus 로고    scopus 로고
    • Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    • Joseph, S. B., A. Castrillo, B. A. Laffitte, D. J. Mangelsdorf, and P. Tontonoz. 2003. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat. Med. 9: 213-219.
    • (2003) Nat. Med. , vol.9 , pp. 213-219
    • Joseph, S.B.1    Castrillo, A.2    Laffitte, B.A.3    Mangelsdorf, D.J.4    Tontonoz, P.5
  • 17
    • 21644487430 scopus 로고    scopus 로고
    • Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in ballooninjured rat carotid arteries
    • Blaschke, F., O. Leppanen, Y. Takata, E. Caglayan, J. Liu, M. C. Fishbein, K. Kappert, K. I. Nakayama, A. R. Collins, E. Fleck, et al. 2004. Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in ballooninjured rat carotid arteries. Circ. Res. 95: e110-e123.
    • (2004) Circ. Res. , vol.95
    • Blaschke, F.1    Leppanen, O.2    Takata, Y.3    Caglayan, E.4    Liu, J.5    Fishbein, M.C.6    Kappert, K.7    Nakayama, K.I.8    Collins, A.R.9    Fleck, E.10
  • 18
    • 33947367803 scopus 로고    scopus 로고
    • Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells
    • Wente, W., M. B. Brenner, H. Zitzer, J. Gromada, and A. M. Efanov. 2007. Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells. Endocrinology. 148: 1843-1849.
    • (2007) Endocrinology , vol.148 , pp. 1843-1849
    • Wente, W.1    Brenner, M.B.2    Zitzer, H.3    Gromada, J.4    Efanov, A.M.5
  • 19
    • 33746176754 scopus 로고    scopus 로고
    • Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist
    • Chuu, C. P., R. A. Hiipakka, J. M. Kokontis, J. Fukuchi, R. Y. Chen, and S. Liao. 2006. Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist. Cancer Res. 66: 6482-6486.
    • (2006) Cancer Res. , vol.66 , pp. 6482-6486
    • Chuu, C.P.1    Hiipakka, R.A.2    Kokontis, J.M.3    Fukuchi, J.4    Chen, R.Y.5    Liao, S.6
  • 20
    • 7444259771 scopus 로고    scopus 로고
    • Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells
    • Fukuchi, J., J. M. Kokontis, R. A. Hiipakka, C. P. Chuu, and S. Liao. 2004. Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells. Cancer Res. 64: 7686-7689.
    • (2004) Cancer Res. , vol.64 , pp. 7686-7689
    • Fukuchi, J.1    Kokontis, J.M.2    Hiipakka, R.A.3    Chuu, C.P.4    Liao, S.5
  • 21
    • 57249094223 scopus 로고    scopus 로고
    • Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest
    • Meng, Z. X., J. Nie, J. J. Ling, J. X. Sun, Y. X. Zhu, L. Gao, J. H. Lv, D. Y. Zhu, Y. J. Sun, and X. Han. 2009. Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia. 52: 125-135.
    • (2009) Diabetologia , vol.52 , pp. 125-135
    • Meng, Z.X.1    Nie, J.2    Ling, J.J.3    Sun, J.X.4    Zhu, Y.X.5    Gao, L.6    Lv, J.H.7    Zhu, D.Y.8    Sun, Y.J.9    Han, X.10
  • 22
    • 0037213448 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase inhibition by statins inhibits neutrophil activation by ANCA
    • DOI 10.1046/j.1523-1755.2003.00718.x
    • Choi, M., S. Rolle, M. Rane, H. Haller, F. C. Luft, and R. Kettritz. 2003. Extracellular signal-regulated kinase inhibition by statins inhibits neutrophil activation by ANCA. Kidney Int. 63: 96-106. (Pubitemid 35463910)
    • (2003) Kidney International , vol.63 , Issue.1 , pp. 96-106
    • Choi, M.1    Rolle, S.2    Rane, M.3    Haller, H.4    Luft, F.C.5    Kettritz, R.6
  • 23
    • 0036847338 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl coenzyme a reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells
    • Wagner, A. H., M. Gebauer, B. Guldenzoph, and M. Hecker. 2002. 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells. Arterioscler. Thromb. Vasc. Biol. 22: 1784-1789.
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 1784-1789
    • Wagner, A.H.1    Gebauer, M.2    Guldenzoph, B.3    Hecker, M.4
  • 24
    • 33748423356 scopus 로고    scopus 로고
    • Selective LXRalpha inhibitory effects observed in plant extracts of MEH184 (Parthenocissua tricuspidata) and MEH185 (Euscaphis japonica)
    • Kim, K. H., S. H. Choi, T. S. Lee, W. K. Oh, D. S. Kim, and J. B. Kim. 2006. Selective LXRalpha inhibitory effects observed in plant extracts of MEH184 (Parthenocissua tricuspidata) and MEH185 (Euscaphis japonica). Biochem. Biophys. Res. Commun. 349: 513-518.
    • (2006) Biochem. Biophys. Res. Commun. , vol.349 , pp. 513-518
    • Kim, K.H.1    Choi, S.H.2    Lee, T.S.3    Oh, W.K.4    Kim, D.S.5    Kim, J.B.6
  • 26
    • 34247093820 scopus 로고    scopus 로고
    • T0901317 is a potent PXR ligand: Implications for the biology ascribed to LXR
    • Mitro, N., L. Vargas, R. Romeo, A. Koder, and E. Saez. 2007. T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR. FEBS Lett. 581: 1721-1726.
    • (2007) FEBS Lett. , vol.581 , pp. 1721-1726
    • Mitro, N.1    Vargas, L.2    Romeo, R.3    Koder, A.4    Saez, E.5
  • 29
    • 0030007427 scopus 로고    scopus 로고
    • ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
    • Kim, J. B., and B. M. Spiegelman. 1996. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev. 10: 1096-1107.
    • (1996) Genes Dev. , vol.10 , pp. 1096-1107
    • Kim, J.B.1    Spiegelman, B.M.2
  • 30
    • 0027648820 scopus 로고
    • ADD1: A novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation
    • Tontonoz, P., J. B. Kim, R. A. Graves, and B. M. Spiegelman. 1993. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell. Biol. 13: 4753-4759.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4753-4759
    • Tontonoz, P.1    Kim, J.B.2    Graves, R.A.3    Spiegelman, B.M.4
  • 31
    • 10644281006 scopus 로고    scopus 로고
    • Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADD1/SREBP1c
    • Kim, K. H., M. J. Song, E. J. Yoo, S. S. Choe, S. D. Park, and J. B. Kim. 2004. Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADD1/SREBP1c. J. Biol. Chem. 279: 51999-52006.
    • (2004) J. Biol. Chem. , vol.279 , pp. 51999-52006
    • Kim, K.H.1    Song, M.J.2    Yoo, E.J.3    Choe, S.S.4    Park, S.D.5    Kim, J.B.6
  • 32
    • 3242685815 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells
    • Menendez, J. A., L. Vellon, I. Mehmi, B. P. Oza, S. Ropero, R. Colomer, and R. Lupu. 2004. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc. Natl. Acad. Sci. USA. 101: 10715-10720.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 10715-10720
    • Menendez, J.A.1    Vellon, L.2    Mehmi, I.3    Oza, B.P.4    Ropero, S.5    Colomer, R.6    Lupu, R.7
  • 33
    • 0034806134 scopus 로고    scopus 로고
    • Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity
    • Thupari, J. N., M. L. Pinn, and F. P. Kuhajda. 2001. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem. Biophys. Res. Commun. 285: 217-223.
    • (2001) Biochem. Biophys. Res. Commun. , vol.285 , pp. 217-223
    • Thupari, J.N.1    Pinn, M.L.2    Kuhajda, F.P.3
  • 36
    • 34548675597 scopus 로고    scopus 로고
    • Modulation of liver X receptor signaling as novel therapy for prostate cancer
    • Chuu, C. P., J. M. Kokontis, R. A. Hiipakka, and S. Liao. 2007. Modulation of liver X receptor signaling as novel therapy for prostate cancer. J. Biomed. Sci. 14: 543-553.
    • (2007) J. Biomed. Sci. , vol.14 , pp. 543-553
    • Chuu, C.P.1    Kokontis, J.M.2    Hiipakka, R.A.3    Liao, S.4
  • 37
    • 37449030479 scopus 로고    scopus 로고
    • Lipotoxic effects of triacylglycerols in J774.2 macrophages
    • Aronis, A., Z. Madar, and O. Tirosh. 2008. Lipotoxic effects of triacylglycerols in J774.2 macrophages. Nutrition. 24: 167-176.
    • (2008) Nutrition , vol.24 , pp. 167-176
    • Aronis, A.1    Madar, Z.2    Tirosh, O.3
  • 38
    • 33744948514 scopus 로고    scopus 로고
    • Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
    • Malhi, H., S. F. Bronk, N. W. Werneburg, and G. J. Gores. 2006. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J. Biol. Chem. 281: 12093-12101.
    • (2006) J. Biol. Chem. , vol.281 , pp. 12093-12101
    • Malhi, H.1    Bronk, S.F.2    Werneburg, N.W.3    Gores, G.J.4
  • 40
    • 0037147215 scopus 로고    scopus 로고
    • Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1)
    • Wrede, C. E., L. M. Dickson, M. K. Lingohr, I. Briaud, and C. J. Rhodes. 2002. Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J. Biol. Chem. 277: 49676-49684.
    • (2002) J. Biol. Chem. , vol.277 , pp. 49676-49684
    • Wrede, C.E.1    Dickson, L.M.2    Lingohr, M.K.3    Briaud, I.4    Rhodes, C.J.5
  • 41
    • 0032030866 scopus 로고    scopus 로고
    • Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
    • Bollheimer, L. C., R. H. Skelly, M. W. Chester, J. D. McGarry, and C. J. Rhodes. 1998. Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J. Clin. Invest. 101: 1094-1101.
    • (1998) J. Clin. Invest. , vol.101 , pp. 1094-1101
    • Bollheimer, L.C.1    Skelly, R.H.2    Chester, M.W.3    McGarry, J.D.4    Rhodes, C.J.5
  • 42
    • 0036692835 scopus 로고    scopus 로고
    • Cyclin A in cell cycle control and cancer
    • Yam, C. H., T. K. Fung, and R. Y. Poon. 2002. Cyclin A in cell cycle control and cancer. Cell. Mol. Life Sci. 59: 1317-1326.
    • (2002) Cell. Mol. Life Sci. , vol.59 , pp. 1317-1326
    • Yam, C.H.1    Fung, T.K.2    Poon, R.Y.3
  • 44
    • 0026320075 scopus 로고
    • Cyclin A is required for the onset of DNA replication in mammalian fibroblasts
    • Girard, F., U. Strausfeld, A. Fernandez, and N. J. Lamb. 1991. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell. 67: 1169-1179.
    • (1991) Cell , vol.67 , pp. 1169-1179
    • Girard, F.1    Strausfeld, U.2    Fernandez, A.3    Lamb, N.J.4
  • 45
    • 0035252961 scopus 로고    scopus 로고
    • Regulation of the Cdc25A gene by the human papillomavirus type 16 E7 oncogene
    • DOI 10.1038/sj.onc.1204130
    • Katich, S. C., K. Zerfass-Thome, and I. Hoffmann. 2001. Regulation of the Cdc25A gene by the human papillomavirus Type 16 E7 oncogene. Oncogene. 20: 543-550. (Pubitemid 32156178)
    • (2001) Oncogene , vol.20 , Issue.5 , pp. 543-550
    • Katich, S.C.1    Zerfass-Thome, K.2    Hoffmann, I.3
  • 46
    • 0033590632 scopus 로고    scopus 로고
    • A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2
    • Sexl, V., J. A. Diehl, C. J. Sherr, R. Ashmun, D. Beach, and M. F. Roussel. 1999. A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. Oncogene. 18: 573-582.
    • (1999) Oncogene , vol.18 , pp. 573-582
    • Sexl, V.1    Diehl, J.A.2    Sherr, C.J.3    Ashmun, R.4    Beach, D.5    Roussel, M.F.6


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