Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression

Journal of Biological Chemistry

Volumn 290, Issue 9, 2015, Pages 5673-5684

  Tsukuda, Senko ^a,b   Watashi, Koichi ^a   Iwamoto, Masashi ^a   Suzuki, Ryosuke ^a   Aizaki, Hideki ^a   Okada, Maiko ^c   Sugiyama, Masaya ^c   Kojima, Soichi ^b   Tanaka, Yasuhito ^e   Mizokami, Masashi ^d   Li, Jisu ^f   Tong, Shuping ^f   Wakita, Takaji ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b RIKEN   (Japan)

^c ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d 1 7 1 Kohnodai   (Japan)

^e NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^f BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIFE CYCLE; SODIUM;

CHEMICAL SCREENING; CONTINUOUS REPRODUCTION; HEPATITIS B VIRUS INFECTION; HOST SUSCEPTIBILITY; NUCLEOSIDE ANALOGS; PROMOTER ACTIVITIES; RETINOIC ACID RECEPTORS; TRANSCRIPTIONAL ACTIVATIONS;

VIRUSES;

4 [7 ADAMANTYL 6 [(2 METHOXYETHOXY)METHOXY] 2 NAPHTHYL]BENZOIC ACID; ANTIVIRUS AGENT; HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; MESSENGER RNA; RETINOIC ACID RECEPTOR; RO 41 5253; SODIUM BILE ACID COTRANSPORTER; UNCLASSIFIED DRUG; ADAMANTANE; BENZOIC ACID DERIVATIVE; CHROMAN DERIVATIVE; COTRANSPORTER; ORGANIC ANION TRANSPORTER; PROTEIN BINDING; RO 41-5253; SODIUM-BILE ACID COTRANSPORTER;

ANTIVIRAL ACTIVITY; ARTICLE; CELL ADHESION; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG STRUCTURE; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; GENE SILENCING; HEPATITIS B; HEPATOCYTE PERMISSIVENESS; HNTCP GENE; HOST SUSCEPTIBILITY; HUMAN; HUMAN CELL; INNATE IMMUNITY; INTRACELLULAR SIGNALING; LIFE CYCLE STAGE; LIVER CELL; MOLECULAR DYNAMICS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; VIRUS REPLICATION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION; GENETICS; GENOTYPE; HEPATITIS B VIRUS; HEPG2 CELL LINE; HOST PATHOGEN INTERACTION; IMMUNOBLOTTING; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; VIROLOGY;

HEPATITIS B VIRUS;

ADAMANTANE; ANTIVIRAL AGENTS; BENZOATES; CELL LINE, TUMOR; CELLS, CULTURED; CHROMANS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION; GENOTYPE; HEP G2 CELLS; HEPATITIS B VIRUS; HEPATOCYTES; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOBLOTTING; MOLECULAR STRUCTURE; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RECEPTORS, RETINOIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYMPORTERS;

EID: 84923823910     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.602540     Document Type: Article

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