Modulation of Retinoid Signaling by a Cytoplasmic Viral Protein via Sequestration of Sp110b, a Potent Transcriptional Corepressor of Retinoic Acid Receptor, from the Nucleus

Molecular and Cellular Biology

Volumn 23, Issue 21, 2003, Pages 7498-7509

  Watashi, Koichi ^a   Hijikata, Makoto ^a   Tagawa, Ayako ^a   Doi, Takahiro ^a   Marusawa, Hiroyuki ^a,b   Shimotohno, Kunitada ^a  

^a KYOTO UNIVERSITY   (Japan)

^b BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP110B; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CHRONIC LIVER DISEASE; GENETIC TRANSCRIPTION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE; CELL NUCLEUS; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; HEPACIVIRUS; HUMANS; NUCLEAR PROTEINS; RECEPTORS, RETINOIC ACID; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; TRANSCRIPTION, GENETIC; TRETINOIN; TWO-HYBRID SYSTEM TECHNIQUES; VIRAL CORE PROTEINS;

ANIMALIA; HEPATITIS C VIRUS; MINK CELL FOCUS-FORMING VIRUS; RNA VIRUSES;

EID: 0142123224     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.21.7498-7509.2003     Document Type: Article

References (57)

1. Alter, H. J., R. H. Purcell, J. W. Shih, J. C. Melpolder, M. Houghton, Q. L. Choo, and G. Kuo. 1989. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N. Engl. J. Med. 321:1494-1500.
2. Arany, Z., D. Newsome, E. Oldread, D. M. Livingston, and R. Eckner. 1995. A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature 374:81-84,
3. Ariumi, Y., A. Kaida, M. Hatanaka, and K. Shimotohno. 2001. Functional cross-talk of HIV-1 Tat with p53 through its C-terminal domain. Biochem. Biophys. Res. Commun. 287:556-561.
4. Ariumi, Y., A. Kaida, J. Y. Lin, M. Hirota, O. Masui, S. Yamaoka, Y. Taya, and K. Shimotohno. 2000. HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration. Oncogene 19:1491-1499.
5. Bergqvist, A., and C. M. Rice. 2001. Transcriptional activation of the interleukin-2 promoter by hepatitis C virus core protein. J. Virol. 75:772-781.
6. Bloch, D. B., A. Nakajima, T. Gulick, J. D. Chiche, D. Orth, S. M. de La Monte, and K. D. Bloch. 2000. Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. Mol. Cell. Biol. 20:6138-6146.
7. Chambon, P. 1996. A decade of molecular biology of retinoic acid receptors. FASEB J. 10:940-954.
8. Choo, Q. L., G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
9. Denis, G. V. 2001. Duality in bromodomain-containing protein complexes. Front. Biosci. 6:D849-D852.
10. Dyson, M. H., S. Rose, and L. C. Mahadevan. 2001. Acetyllysine-binding and function of bromodomain-containing proteins in chromatin. Front. Biosci. 6:D853-D865.
11. Eck-Enriquez, K., T. L. Kiefer, L. L. Spriggs, and S. M. Hill. 2000. Pathways through which a regimen of melatonin and retinoic acid induces apoptosis in MCF-7 human breast cancer cells. Breast Cancer Res. Treat. 61:229-239.
12. Ferrigno, P., and P. A. Silver. 1999. Regulated nuclear localization of stress-responsive factors: how the nuclear trafficking of protein kinases and transcription factors contributes to cell survival. Oncogene 18:6129-6134.
13. Fronsdal, K., N. Engedal, T. Slagsvold, and F. Saatcioglu. 1998. CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1. J. Biol. Chem. 273:31853-31859.
14. Fukuda, K., K. Tsuchihara, M. Hijikata, S. Nishiguchi, T. Kuroki, and K. Shimotohno. 2001. Hepatitis C virus core protein enhances the activation of the transcription factor, Elkl, in response to mitogenic stimuli. Hepatology 33:159-165.
15. Harnish, D. C., M. S. Scicchitano, S. J. Adelman, C. R. Lyttle, and S. K. Karathanasis. 2000. The role of CBP in estrogen receptor cross-talk with nuclear factor-KB in HepG2 cells. Endocrinology 141:3403-3411.
16. Hayashi, J., H. Aoki, K. Kajino, M. Moriyama, Y. Arakawa, and O. Hino. 2000. Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor of transforming growth factor alpha. Hepatology 32:958-961.
17. Heery, D. M., E. Kalkhoven, S. Hoare, and M. G. Parker. 1997. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387:733-736.
18. Hijikata, M., N. Kato, Y. Ootsuyama, M. Nakagawa, and K. Shimotohno. 1991. Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc. Natl. Acad. Sci. USA 88:5547-5551.
19. Joseph, B., O. Lefebvre, C. Mereau-Richard, P. M. Danze, M. T. Belin-Plancot, and P. Formstecher. 1998. Evidence for the involvement of both retinoic acid receptor- and retinoic X receptor-dependent signaling pathways in the induction of tissue transglutaminase and apoptosis in the human myeloma cell line RPMI 8226. Blood 91:2423-2432.
20. Kato, N., M. Hijikata, Y. Ootsuyama, M. Nakagawa, S. Ohkoshi, T. Sugimura, and K. Shimotohno. 1990. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc. Natl. Acad. Sci. USA 87:9524-9528.
21. Kiyono, T., A. Hiraiwa, S. Ishii, T. Takahashi, and M. Ishibashi. 1994. Inhibition of p53-mediated transactivation by E6 of type 1, but not type 5, 8, of 47, human papillomavirus of cutaneous origin. J. Virol. 68:4656-4661.
22. Leo, C., and J. D. Chen. 2000. The SRC family of nuclear receptor coactivators. Gene 245:1-11.
23. Lerat, H., M. Honda, M. R. Beard, K. Loesch, J. Sun, Y. Yang, M. Okuda, R. Gosert, S. Y. Xiao, S. A. Weinman, and S. M. Lemon. 2002. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 122:352-365.
24. Liu, Y., A. L. Colosimo, X. J. Yang, and D. Liao. 2000, Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF. Mol. Cell. Biol. 20:5540-5553.
25. Lu, W., S. Y. Lo, M. Chen, K. Wu, Y. K. Fung, and J. H. Ou. 1999. Activation of p53 tumor suppressor by hepatitis C virus core protein. Virology 264:134-141.
26. Lundblad, J. R., R. P. Kwok, M. E. Laurance, M. L. Harter, and R. H. Goodman. 1995, Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature 374:85-88.
27. Martire, G., A. Viola, L. Iodice, L. V. Lotti, R. Gradini, and S. Bonatti. 2001. Hepatitis C virus structural proteins reside in the endoplasmic reticulum as well as in the intermediate compartment/cis-Golgi complex region of stably transfected cells. Virology 280:176-182.
28. Marusawa, H., M. Hijikata, T. Chiba, and K. Shimotohno. 1999. Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-κB activation. J. Virol. 73:4713-4720.
29. Mesnard, J. M., and C. Devaux. 1999. Multiple control levels of cell proliferation by human T-cell leukemia virus type 1 Tax protein. Virology 257:277-284.
30. Min, G., H. Kim, Y. Bae, L. Petz, and J. K. Kemper. 2002. Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators. J. Biol. Chem. 277:34626-34633.
31. Moriya, K., H. Fujie, Y. Shintani, H. Yotsuyanagi, T. Tsutsumi, K. Ishibashi Y. Matsuura, S, Kimura, T. Miyamura, and K. Koike. 1998. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat. Med. 4:1065-1067.
32. Moriya, K., H. Yotsuyanagi, Y. Shintani, H. Fujie, K. Ishibashi, Y, Matsuura, T. Miyamura, and K. Koike. 1997. Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. J. Gen. Virol. 78:1527-1531.
33. Munger, K. 2002. The role of human papillomaviruses in human cancers. Front. Biosci. 7:d641-d649.
34. Niwa, H., K. Yamamura, and J. Miyazaki. 1991. Efficient selection for high-expression transfectants with a novel eukaryotic rector. Gene 108:193-199.
35. Oliverio, S., A. Amendola, C. Rodolfo, A. Spinedi, and M. Piacentini. 1999. Inhibition of "tissue" transglutaminase increases cell survival by preventing apoptosis. J. Biol. Chem. 274:34123-34128.
36. Ou, H., J. Haendeler, M. R. Aebly, L. A. Kelly, B. C. Cholewa, G. Koike, A. Kwitek-Black, H. J. Jacob, B. C. Berk, and J. M. Miano. 2000. Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells. Circ. Res. 87:881-887.
37. Park, J. S., E. J. Kim, H. J. Kwon, E. S. Hwang, S. E. Namkoong, and S. J. Um. 2000. Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis. J. Biol. Chem. 275:6764-6769.
38. Patel, D., S. M. Huang, L. A. Baglia, and D. J. McCance. 1999. The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300. EMBO J. 18:5061-5072.
39. Ravi, R., B. Mookerjee, Y. van Hensbergen, G. C. Bedi, A. Giordano, W. S. El-Deiry, E. J. Fuchs, and A. Bedi. 1998. p53-mediated repression of nuclear factor-κB RelA via the transcriptional integrator p300. Cancer Res. 58:4531-4536.
40. Ray, R. B., L. M. Lagging, K. Meyer, and R. Ray. 1996. Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. J. Virol. 70:4438-4443.
41. Ray, R. B., K. Meyer, and R. Ray. 1996. Suppression of apoptotic cell death by hepatitis C virus core protein.Virology 226:176-182.
42. Ray, R. B., R. Steele, K. Meyer, and R. Ray. 1997. Transcriptional repression of p53 promoter by hepatitis C virus core protein. J. Biol. Chem. 272:10983-10986.
43. Ruggieri, A., T. Harada, Y. Matsuura, and T. Miyamura. 1997. Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein, Virology 229:68-76.
44. Sang, N., J. Caro, and A. Giordano. 2002. Adenoviral EIA everlasting tool, versatile applications, continuous contributions and new hypotheses. Front. Biosci. 7:d407-d413
45. Schreiber, V., M. Molinete, H. Boeuf, G. de Murcia, and J. Menissier-de Murcia. 1992. The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity. EMBO J. 11:3263-3269.
46. Scoggin, K. E., A. Ulloa, and J. K. Nyborg. 2001. The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation. Mol. Cell Biol. 21:5520-5530.
47. Sheppard, K. A., K. M. Phelps, A. J. Williams, D. Thanos, C. K. Glass, M. G. Rosenfeld, M. E. Gerritsen, and T. Collins. 1998. Nuclear integration of glucocorticoid receptor and nuclear factor-KB signaling by CREB-binding protein and steroid receptor coactivator-1. J. Biol. Chem. 273:29291-29294.
48. Shrivastava, A., S. K. Manna, R. Ray, and B. B. Aggarwal. 1998. Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors. J. Virol. 72:9722-9728.
49. Stein, G. S., A. J. van Wijnen, J. L. Stein, J. B. Lian, M. Montecino, J. Choi, K. Zaidi, and A. Javed. 2000. Intranuclear trafficking of transcription factors: implications for biological control. J. Cell Sci. 113:2527-2533.
50. Takahashi, T., N. Suwabe, P. Dai, M. Yamamoto, S. Ishii, and T. Nakano. 2000. Inhibitory interaction of c-Myb and GATA-1 via transcriptional co-activator CBP. Oncogene 19:134-140.
51. Tsuchihara, K., M. Hijikata, K. Fukuda, T. Kuroki, N. Yamamoto, and K. Shimotohno. 1999. Hepatitis C virus core protein regulates cell growth and signal transduction pathway transmitting growth stimuli. Virology 258:100-107.
52. Tsutsumi, T., T. Suzuki, T. Shimoike, R. Suzuki, K. Moriya, Y. Shintani, H. Fujie, Y. Matsuura, K. Koike, and T. Miyamura. 2002. Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity. Hepatology 35:937-946.
53. Van Orden, K., J. P. Yan, A. Ulloa, and J. K. Nyborg. 1999. Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control. Oncogene 18:3766-3772.
54. Watashi, K., M. Hijikata, H. Marusawa, T. Doi, and K. Shimotohno. 2001. Cytoplasmic localization is important for transcription factor nuclear factor-κB activation by hepatitis C virus core protein through its amino terminal region. Virology 286:391-402.
55. Yoshida, T., T. Hanada, T. Tokuhisa, K. Kosai, M. Sata, M. Kohara, and A. Yoshimura. 2002. Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J. Exp. Med. 196:641-653.
56. You, L. R., C. M. Chen, and Y. H. Lee. 1999. Hepatitis C virus core protein enhances NF-κB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha. J. Virol. 73:1672-1681.
57. Zeng, L., and M. M. Zhou. 2002. Bromodomain: an acetyl-lysine binding domain. FEBS Lett. 513:124-128.