The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains

eLife

Volumn 5, Issue September2016, 2016, Pages

  Conlon, Erin G ^a   Lu, Lei ^b   Sharma, Aarti ^b   Yamazaki, Takashi ^a   Tang, Timothy ^a   Shneider, Neil A ^b   Manley, James L ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C9ORF72 GENE ENCODING PROTEIN; GUANINE QUADRUPLEX; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; NUCLEAR PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; C9ORF72 PROTEIN, HUMAN; GUANINE NUCLEOTIDE EXCHANGE C9ORF72; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN GROUP F H; RNA;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; ASTROCYTE; C9ORF72 GENE; CEREBELLUM; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA TRANSCRIPTION; ESCHERICHIA COLI; FIBROBLAST; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION SYSTEM; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOFLUORESCENCE TEST; NERVE DEGENERATION; PROTEIN BINDING; PROTEIN PURIFICATION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA SPLICING; SKIN BIOPSY; SPINAL CORD; WESTERN BLOTTING; GENETICS; METABOLISM; PATHOPHYSIOLOGY;

AMYOTROPHIC LATERAL SCLEROSIS; C9ORF72 PROTEIN; G-QUADRUPLEXES; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP F-H; HUMANS; RNA; RNA SPLICING;

EID: 84990032164     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.17820     Document Type: Article

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