A G-Rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing

Journal of Neurochemistry

Volumn 121, Issue 5, 2012, Pages 763-773

  Fisette, Jean François ^a   Montagna, Daniel R ^a   Mihailescu, Mihaela Rita ^b   Wolfe, Michael S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DUQUESNE UNIVERSITY   (United States)

Author keywords

Alzheimer disease; cis acting elements; mRNA splicing; protease; trans factor proteins

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE 1; GUANINE QUADRUPLEX; ISOPROTEIN; MESSENGER RNA; RIBONUCLEOPROTEIN; RIBONUCLEOPROTEIN H; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DNA BINDING; DNA STRUCTURE; EXON; G RICH SEQUENCE; GENE DELETION; GENE MUTATION; GENE SEQUENCE; GENE SILENCING; GENETIC REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ALTERNATIVE SPLICING; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; BASE SEQUENCE; CELLS, CULTURED; CIRCULAR DICHROISM; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXONS; G-QUADRUPLEXES; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION;

EID: 84860518297     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07680.x     Document Type: Article

References (29)

1. Beaudoin J. D., and, Perreault J. P., (2010) 5'-UTR G-quadruplex structures acting as translational repressors. Nucleic Acids Res. 38, 7022-7036.
2. Buratti E., Baralle M., De Conti L., Baralle D., Romano M., Ayala Y. M., and, Baralle F. E., (2004) hnRNP H binding at the 5' splice site correlates with the pathological effect of two intronic mutations in the NF-1 and TSHbeta genes. Nucleic Acids Res. 32, 4224-4236. (Pubitemid 39232295)
3. Burge S., Parkinson G. N., Hazel P., Todd A. K., and, Neidle S., (2006) Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res. 34, 5402-5415. (Pubitemid 44742430)
4. Caputi M., and, Zahler A. M., (2001) Determination of the RNA binding specificity of the heterogeneous nuclear ribonucleoprotein (hnRNP) H/H'/F/2H9 family. J. Biol. Chem. 276, 43850-43859.
5. Caputi M., and, Zahler A. M., (2002) SR proteins and hnRNP H regulate the splicing of the HIV-1 tev-specific exon 6D. EMBO J. 21, 845-855. (Pubitemid 34174064)
6. Chou M. Y., Rooke N., Turck C. W., and, Black D. L., (1999) hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. Mol. Cell. Biol. 19, 69-77. (Pubitemid 29018410)
7. Didiot M. C., Tian Z., Schaeffer C., Subramanian M., Mandel J. L., and, Moine H., (2008) The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer. Nucleic Acids Res. 36, 4902-4912.
8. Fisette J. F., Toutant J., Dugre-Brisson S., Desgroseillers L., and, Chabot B., (2010) hnRNP A1 and hnRNP H can collaborate to modulate 5' splice site selection. RNA 16, 228-238.
9. Garneau D., Revil T., Fisette J. F., and, Chabot B., (2005) Heterogeneous nuclear ribonucleoprotein F/H proteins modulate the alternative splicing of the apoptotic mediator Bcl-x. J. Biol. Chem. 280, 22641-22650. (Pubitemid 40853168)
10. Hua Y., Sahashi K., Hung G., Rigo F., Passini M. A., Bennett C. F., and, Krainer A. R., (2010) Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model. Genes Dev. 24, 1634-1644.
11. Joachimi A., Benz A., and, Hartig J. S., (2009) A comparison of DNA and RNA quadruplex structures and stabilities. Bioorg. Med. Chem. 17, 6811-6815.
12. Laird F. M., Cai H., Savonenko A. V., et al. (2005) BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J. Neurosci. 25, 11693-11709. (Pubitemid 43098462)
13. McConlogue L., Buttini M., Anderson J. P., et al. (2007) Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice. J. Biol. Chem. 282, 26326-26334. (Pubitemid 47443774)
14. Meredith J. E., Jr, Thompson L. A., Toyn J. H., et al. (2008) P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice. J. Pharmacol. Exp. Ther. 326, 502-513.
15. Modafferi E. F., and, Black D. L., (1997) A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon. Mol. Cell. Biol. 17, 6537-6545. (Pubitemid 27451200)
16. Mowrer K. R., and, Wolfe M. S., (2008) Promotion of BACE1 mRNA alternative splicing reduces amyloid beta-peptide production. J. Biol. Chem. 283, 18694-18701.
17. Mowrer K. R., and, Wolfe M. S., (2009) Identification of a cis-acting element involved in the regulation of BACE1 mRNA alternative splicing. J. Neurochem. 109, 1008-1016.
18. Pan Q., Shai O., Lee L. J., Frey B. J., and, Blencowe B. J., (2008) Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat. Genet. 40, 1413-1415.
19. Piotto M., Saudek V., and, Sklenar V., (1992) Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. J. Biomol. NMR 2, 661-665.
20. Satyanarayana M., Kim Y. A., Rzuczek S. G., Pilch D. S., Liu A. A., Liu L. F., Rice J. E., and, LaVoie E. J., (2010) Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity. Bioorg. Med. Chem. Lett. 20, 3150-3154.
21. Scaria V., Hariharan M., Arora A., and, Maiti S., (2006) Quadfinder: server for identification and analysis of quadruplex-forming motifs in nucleotide sequences. Nucleic Acids Res. 34, W683-685. (Pubitemid 44529857)
22. Shapiro M. B., and, Senapathy P., (1987) RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res. 15, 7155-7174.
23. Singer O., Marr R. A., Rockenstein E., Crews L., Coufal N. G., Gage F. H., Verma I. M., and, Masliah E., (2005) Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat. Neurosci. 8, 1343-1349. (Pubitemid 41630422)
24. Tanahashi H., and, Tabira T., (2007) A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation. Neurosci. Lett. 428, 103-108. (Pubitemid 350051170)
25. Viglasky V., Bauer L., and, Tluckova K., (2010) Structural features of intra- and intermolecular G-quadruplexes derived from telomeric repeats. Biochemistry 49, 2110-2120.
26. Villemaire J., Dion I., Elela S. A., and, Chabot B., (2003) Reprogramming alternative pre-messenger RNA splicing through the use of protein-binding antisense oligonucleotides. J. Biol. Chem. 278, 50031-50039. (Pubitemid 37548839)
27. Walsh D. M., and, Selkoe D. J., (2007) A beta oligomers-a decade of discovery. J. Neurochem. 101, 1172-1184.
28. Wang E. T., Sandberg R., Luo S., Khrebtukova I., Zhang L., Mayr C., Kingsmore S. F., Schroth G. P., and, Burge C. B., (2008) Alternative isoform regulation in human tissue transcriptomes. Nature 456, 470-476. (Pubitemid 352759009)
29. Zhou W., Brand N. J., and, Ying L., (2011) G-quadruplexes-novel mediators of gene function. J. Cardiovasc. Transl. Res. 4, 256-270.