메뉴 건너뛰기




Volumn 3, Issue , 2016, Pages

Modeling-Enabled Systems Nutritional Immunology

Author keywords

big data; complex systems; computational modeling; informatics; nutrition; nutritional immunology; systems biology

Indexed keywords


EID: 84989318199     PISSN: None     EISSN: 2296861X     Source Type: Journal    
DOI: 10.3389/fnut.2016.00005     Document Type: Review
Times cited : (22)

References (132)
  • 1
    • 84921193624 scopus 로고
    • The history of nutritional immunology
    • Beisel WR. The history of nutritional immunology. J Nutr Immunol (1991) 1(1):5–40.
    • (1991) J Nutr Immunol , vol.1 , Issue.1 , pp. 5-40
    • Beisel, W.R.1
  • 2
    • 0026522006 scopus 로고
    • History of nutritional immunology: introduction and overview1
    • Beisel WR. History of nutritional immunology: introduction and overview1. J Nutr (1992) 122(3S):591.
    • (1992) J Nutr , vol.122 , Issue.3S , pp. 591
    • Beisel, W.R.1
  • 3
    • 79952784010 scopus 로고    scopus 로고
    • Emerging paradigms in immunonutrition
    • 21435623
    • Satyaraj E. Emerging paradigms in immunonutrition. Top Companion Anim Med (2011) 26(1):25–32.10.1053/j.tcam.2011.01.00421435623
    • (2011) Top Companion Anim Med , vol.26 , Issue.1 , pp. 25-32
    • Satyaraj, E.1
  • 4
    • 4444289138 scopus 로고    scopus 로고
    • A CLA’s act: feeding away inflammation
    • Greicius G, Arulampalam V, Pettersson S. A CLA’s act: feeding away inflammation. Gastroenterology (2004) 127(3):994–6.10.1053/j.gastro.2004.07.038
    • (2004) Gastroenterology , vol.127 , Issue.3 , pp. 994-996
    • Greicius, G.1    Arulampalam, V.2    Pettersson, S.3
  • 5
    • 0024993017 scopus 로고
    • Micronutrients and immune functions
    • Bendich A, Chandra RK. Micronutrients and immune functions. Ann N Y Acad Sci (1990) 587:3–320.10.1111/j.1749-6632.1990.tb00144.x
    • (1990) Ann N Y Acad Sci , vol.587 , pp. 3-320
    • Bendich, A.1    Chandra, R.K.2
  • 6
    • 0030803977 scopus 로고    scopus 로고
    • Nutrition and the immune system: an introduction
    • 9250133
    • Chandra RK. Nutrition and the immune system: an introduction. Am J Clin Nutr (1997) 66(2):460S–3S.9250133
    • (1997) Am J Clin Nutr , vol.66 , Issue.2 , pp. 460S-463
    • Chandra, R.K.1
  • 7
    • 84655169635 scopus 로고    scopus 로고
    • A systems biology approach to nutritional immunology-focus on innate immunity
    • Afacan NJ, Fjell CD, Hancock RE. A systems biology approach to nutritional immunology-focus on innate immunity. Mol Aspects Med (2012) 33(1):14–25.10.1016/j.mam.2011.10.013
    • (2012) Mol Aspects Med , vol.33 , Issue.1 , pp. 14-25
    • Afacan, N.J.1    Fjell, C.D.2    Hancock, R.E.3
  • 8
    • 84947038529 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson disease – the gut-brain axis and environmental factors
    • Klingelhoefer L, Reichmann H. Pathogenesis of Parkinson disease – the gut-brain axis and environmental factors. Nat Rev Neurol (2015) 11(11):625–36.10.1038/nrneurol.2015.197
    • (2015) Nat Rev Neurol , vol.11 , Issue.11 , pp. 625-636
    • Klingelhoefer, L.1    Reichmann, H.2
  • 9
    • 71549163142 scopus 로고    scopus 로고
    • Modeling and simulation of the immune system as a self-regulating network
    • 19897090
    • Kim PS, Levy D, Lee PP. Modeling and simulation of the immune system as a self-regulating network. Methods Enzymol (2009) 467:79–109.10.1016/S0076-6879(09)67004-X19897090
    • (2009) Methods Enzymol , vol.467 , pp. 79-109
    • Kim, P.S.1    Levy, D.2    Lee, P.P.3
  • 10
    • 79959201412 scopus 로고    scopus 로고
    • Human nutrition, the gut microbiome and the immune system
    • 21677749
    • Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI. Human nutrition, the gut microbiome and the immune system. Nature (2011) 474(7351):327–36.10.1038/nature1021321677749
    • (2011) Nature , vol.474 , Issue.7351 , pp. 327-336
    • Kau, A.L.1    Ahern, P.P.2    Griffin, N.W.3    Goodman, A.L.4    Gordon, J.I.5
  • 11
    • 84866423583 scopus 로고    scopus 로고
    • The human gut microbiome: current knowledge, challenges, and future directions
    • 22683238
    • Dave M, Higgins PD, Middha S, Rioux KP. The human gut microbiome: current knowledge, challenges, and future directions. Transl Res (2012) 160(4):246–57.10.1016/j.trsl.2012.05.00322683238
    • (2012) Transl Res , vol.160 , Issue.4 , pp. 246-257
    • Dave, M.1    Higgins, P.D.2    Middha, S.3    Rioux, K.P.4
  • 12
  • 14
    • 41849127118 scopus 로고    scopus 로고
    • Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
    • 18407065
    • Turnbaugh PJ, Bäckhed F, Fulton L, Gordon JI. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe (2008) 3(4):213–23.10.1016/j.chom.2008.02.01518407065
    • (2008) Cell Host Microbe , vol.3 , Issue.4 , pp. 213-223
    • Turnbaugh, P.J.1    Bäckhed, F.2    Fulton, L.3    Gordon, J.I.4
  • 15
    • 77950669604 scopus 로고    scopus 로고
    • The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice
    • 20368178
    • Turnbaugh PJ, Ridaura VK, Faith JJ, Rey FE, Knight R, Gordon JI. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med (2009) 1(6):ra14–6.10.1126/scitranslmed.300032220368178
    • (2009) Sci Transl Med , vol.1 , Issue.6 , pp. ra14-ra16
    • Turnbaugh, P.J.1    Ridaura, V.K.2    Faith, J.J.3    Rey, F.E.4    Knight, R.5    Gordon, J.I.6
  • 16
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • 17183312
    • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature (2006) 444(7122):1027–31.10.1038/nature0541417183312
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 17
    • 84892828465 scopus 로고    scopus 로고
    • Diet rapidly and reproducibly alters the human gut microbiome
    • 24336217
    • David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature (2014) 505(7484):559–63.10.1038/nature1282024336217
    • (2014) Nature , vol.505 , Issue.7484 , pp. 559-563
    • David, L.A.1    Maurice, C.F.2    Carmody, R.N.3    Gootenberg, D.B.4    Button, J.E.5    Wolfe, B.E.6
  • 18
    • 84867387387 scopus 로고    scopus 로고
    • Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria
    • 22511958
    • Bassaganya-Riera J, Viladomiu M, Pedragosa M, De Simone C, Hontecillas R. Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria. PLoS One (2012) 7(4):e34676.10.1371/journal.pone.003467622511958
    • (2012) PLoS One , vol.7 , Issue.4 , pp. e34676
    • Bassaganya-Riera, J.1    Viladomiu, M.2    Pedragosa, M.3    De Simone, C.4    Hontecillas, R.5
  • 19
    • 79956301905 scopus 로고    scopus 로고
    • Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans
    • 21596990
    • Muegge BD, Kuczynski J, Knights D, Clemente JC, González A, Fontana L, et al. Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science (2011) 332(6032):970–4.10.1126/science.119871921596990
    • (2011) Science , vol.332 , Issue.6032 , pp. 970-974
    • Muegge, B.D.1    Kuczynski, J.2    Knights, D.3    Clemente, J.C.4    González, A.5    Fontana, L.6
  • 20
    • 84893013094 scopus 로고    scopus 로고
    • High-fat diet alters gut microbiota physiology in mice
    • 24030595
    • Daniel H, Moghaddas Gholami A, Berry D, Desmarchelier C, Hahne H, Loh G, et al. High-fat diet alters gut microbiota physiology in mice. ISME J (2014) 8(2):295–308.10.1038/ismej.2013.15524030595
    • (2014) ISME J , vol.8 , Issue.2 , pp. 295-308
    • Daniel, H.1    Moghaddas Gholami, A.2    Berry, D.3    Desmarchelier, C.4    Hahne, H.5    Loh, G.6
  • 21
    • 0038109994 scopus 로고    scopus 로고
    • Autoimmunity associated with anti-tumor necrosis factor α treatment in Crohn’s disease: a prospective cohort study
    • Vermeire S, Noman M, Van Assche G, Baert F, Van Steen K, Esters N, et al. Autoimmunity associated with anti-tumor necrosis factor α treatment in Crohn’s disease: a prospective cohort study. Gastroenterology (2003) 125(1):32–9.10.1016/S0016-5085(03)00701-7
    • (2003) Gastroenterology , vol.125 , Issue.1 , pp. 32-39
    • Vermeire, S.1    Noman, M.2    Van Assche, G.3    Baert, F.4    Van Steen, K.5    Esters, N.6
  • 22
    • 84857381354 scopus 로고    scopus 로고
    • Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR gamma to suppress colitis
    • Bassaganya-Riera J, Viladomiu M, Pedragosa M, De Simone C, Carbo A, Shaykhutdinov R, et al. Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR gamma to suppress colitis. PLoS One (2012) 7(2):e31238.10.1371/journal.pone.0031238
    • (2012) PLoS One , vol.7 , Issue.2 , pp. e31238
    • Bassaganya-Riera, J.1    Viladomiu, M.2    Pedragosa, M.3    De Simone, C.4    Carbo, A.5    Shaykhutdinov, R.6
  • 23
    • 64149109679 scopus 로고    scopus 로고
    • Dietary modulation of peroxisome proliferator-activated receptor gamma
    • 19017686
    • Marion-Letellier R, Déchelotte P, Iacucci M, Ghosh S. Dietary modulation of peroxisome proliferator-activated receptor gamma. Gut (2009) 58(4):586–93.10.1136/gut.2008.16285919017686
    • (2009) Gut , vol.58 , Issue.4 , pp. 586-593
    • Marion-Letellier, R.1    Déchelotte, P.2    Iacucci, M.3    Ghosh, S.4
  • 24
    • 77955920757 scopus 로고    scopus 로고
    • Dietary CLA and n-3 PUFA in inflammatory bowel disease
    • Bassaganya-Riera J, Hontecillas R. Dietary CLA and n-3 PUFA in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care (2010) 13(5):569.10.1097/MCO.0b013e32833b648e
    • (2010) Curr Opin Clin Nutr Metab Care , vol.13 , Issue.5 , pp. 569
    • Bassaganya-Riera, J.1    Hontecillas, R.2
  • 25
    • 84866986817 scopus 로고    scopus 로고
    • Computational systems biology and in silico modeling of the human microbiome
    • 22589385
    • Borenstein E. Computational systems biology and in silico modeling of the human microbiome. Brief Bioinform (2012) 13(6):769–80.10.1093/bib/bbs02222589385
    • (2012) Brief Bioinform , vol.13 , Issue.6 , pp. 769-780
    • Borenstein, E.1
  • 26
    • 84878012036 scopus 로고    scopus 로고
    • Nutritional protective mechanisms against gut inflammation
    • 23541470
    • Viladomiu M, Hontecillas R, Yuan L, Lu P, Bassaganya-Riera J. Nutritional protective mechanisms against gut inflammation. J Nutr Biochem (2013) 24(6):929–39.10.1016/j.jnutbio.2013.01.00623541470
    • (2013) J Nutr Biochem , vol.24 , Issue.6 , pp. 929-939
    • Viladomiu, M.1    Hontecillas, R.2    Yuan, L.3    Lu, P.4    Bassaganya-Riera, J.5
  • 27
    • 84942874856 scopus 로고    scopus 로고
    • Early infancy microbial and metabolic alterations affect risk of childhood asthma
    • 26424567
    • Arrieta MC, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med (2015) 7(307):ra152–307.10.1126/scitranslmed.aab227126424567
    • (2015) Sci Transl Med , vol.7 , Issue.307 , pp. ra152-ra307
    • Arrieta, M.C.1    Stiemsma, L.T.2    Dimitriu, P.A.3    Thorson, L.4    Russell, S.5    Yurist-Doutsch, S.6
  • 28
    • 84943653785 scopus 로고    scopus 로고
    • Microbiota-dependent sequelae of acute infection compromise tissue-specific immunity
    • 26451485
    • Fonseca DM, Hand TW, Han SJ, Gerner MY, Glatman Zaretsky A, Byrd AL, et al. Microbiota-dependent sequelae of acute infection compromise tissue-specific immunity. Cell (2015) 163(2):354–66.10.1016/j.cell.2015.08.03026451485
    • (2015) Cell , vol.163 , Issue.2 , pp. 354-366
    • Fonseca, D.M.1    Hand, T.W.2    Han, S.J.3    Gerner, M.Y.4    Glatman Zaretsky, A.5    Byrd, A.L.6
  • 29
    • 64749106669 scopus 로고    scopus 로고
    • Do symbiotic bacteria subvert host immunity?
    • 19369952
    • Hooper LV. Do symbiotic bacteria subvert host immunity? Nat Rev Microbiol (2009) 7(5):367–74.10.1038/nrmicro211419369952
    • (2009) Nat Rev Microbiol , vol.7 , Issue.5 , pp. 367-374
    • Hooper, L.V.1
  • 30
    • 0037270866 scopus 로고    scopus 로고
    • Intestinal IgA synthesis: regulation of front-line body defences
    • 12511876
    • Fagarasan S, Honjo T. Intestinal IgA synthesis: regulation of front-line body defences. Nat Rev Immunol (2003) 3(1):63–72.10.1038/nri98212511876
    • (2003) Nat Rev Immunol , vol.3 , Issue.1 , pp. 63-72
    • Fagarasan, S.1    Honjo, T.2
  • 31
    • 84909641363 scopus 로고    scopus 로고
    • Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease
    • 25206258
    • Trop TK. Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease. World J Gastroenterol (2014) 20(33):11505.10.3748/wjg.v20.i33.1150525206258
    • (2014) World J Gastroenterol , vol.20 , Issue.33 , pp. 11505
    • Trop, T.K.1
  • 32
    • 79960316106 scopus 로고    scopus 로고
    • Soluble fibers and resistant starch ameliorate disease activity in interleukin-10-deficient mice with inflammatory bowel disease
    • Bassaganya-Riera J, DiGuardo M, Viladomiu M, de Horna A, Sanchez S, Einerhand AW, et al. Soluble fibers and resistant starch ameliorate disease activity in interleukin-10-deficient mice with inflammatory bowel disease. J Nutr (2011) 141(7):1318–25.10.3945/jn.111.139022
    • (2011) J Nutr , vol.141 , Issue.7 , pp. 1318-1325
    • Bassaganya-Riera, J.1    DiGuardo, M.2    Viladomiu, M.3    de Horna, A.4    Sanchez, S.5    Einerhand, A.W.6
  • 33
    • 84859303007 scopus 로고    scopus 로고
    • Prebiotics and probiotics their role in the management of gastrointestinal disorders in adults
    • 22127952
    • Quigley EM. Prebiotics and probiotics their role in the management of gastrointestinal disorders in adults. Nutr Clin Pract (2012) 27(2):195–200.10.1177/088453361142392622127952
    • (2012) Nutr Clin Pract , vol.27 , Issue.2 , pp. 195-200
    • Quigley, E.M.1
  • 34
    • 84883139076 scopus 로고    scopus 로고
    • The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
    • 23821742
    • den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res (2013) 54(9):2325–40.10.1194/jlr.R03601223821742
    • (2013) J Lipid Res , vol.54 , Issue.9 , pp. 2325-2340
    • den Besten, G.1    van Eunen, K.2    Groen, A.K.3    Venema, K.4    Reijngoud, D.J.5    Bakker, B.M.6
  • 35
    • 79551577263 scopus 로고    scopus 로고
    • Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes
    • 21226616
    • Musso G, Gambino R, Cassader M. Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes. Annu Rev Med (2011) 62:361–80.10.1146/annurev-med-012510-17550521226616
    • (2011) Annu Rev Med , vol.62 , pp. 361-380
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 36
    • 33746346757 scopus 로고    scopus 로고
    • Reclassification of Bacteroides distasonis, Bacteroides goldsteinii and Bacteroides merdae as Parabacteroides distasonis gen. nov., comb. nov., Parabacteroides goldsteinii comb. nov. and Parabacteroides merdae comb. nov
    • 16825636
    • Sakamoto M, Benno Y. Reclassification of Bacteroides distasonis, Bacteroides goldsteinii and Bacteroides merdae as Parabacteroides distasonis gen. nov., comb. nov., Parabacteroides goldsteinii comb. nov. and Parabacteroides merdae comb. nov. Int J Syst Evol Microbiol (2006) 56(7):1599–605.10.1099/ijs.0.64192-016825636
    • (2006) Int J Syst Evol Microbiol , vol.56 , Issue.7 , pp. 1599-1605
    • Sakamoto, M.1    Benno, Y.2
  • 37
    • 78650803767 scopus 로고    scopus 로고
    • Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition
    • 21087444
    • Kverka M, Zakostelska Z, Klimesova K, Sokol D, Hudcovic T, Hrncir T, et al. Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition. Clin Exp Immunol (2011) 163(2):250–9.10.1111/j.1365-2249.2010.04286.x21087444
    • (2011) Clin Exp Immunol , vol.163 , Issue.2 , pp. 250-259
    • Kverka, M.1    Zakostelska, Z.2    Klimesova, K.3    Sokol, D.4    Hudcovic, T.5    Hrncir, T.6
  • 38
    • 84858376593 scopus 로고    scopus 로고
    • The impact of the gut microbiota on human health: an integrative view
    • 22424233
    • Clemente JC, Ursell LK, Parfrey LW, Knight R. The impact of the gut microbiota on human health: an integrative view. Cell (2012) 148(6):1258–70.10.1016/j.cell.2012.01.03522424233
    • (2012) Cell , vol.148 , Issue.6 , pp. 1258-1270
    • Clemente, J.C.1    Ursell, L.K.2    Parfrey, L.W.3    Knight, R.4
  • 39
    • 0032173058 scopus 로고    scopus 로고
    • Immune and endocrine regulation of food intake in sick animals
    • 9785035
    • Johnson R. Immune and endocrine regulation of food intake in sick animals. Domest Anim Endocrinol (1998) 15(5):309–19.10.1016/S0739-7240(98)00031-99785035
    • (1998) Domest Anim Endocrinol , vol.15 , Issue.5 , pp. 309-319
    • Johnson, R.1
  • 40
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: when the immune system subjugates the brain
    • 18073775
    • Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci (2008) 9(1):46–56.10.1038/nrn229718073775
    • (2008) Nat Rev Neurosci , vol.9 , Issue.1 , pp. 46-56
    • Dantzer, R.1    O’Connor, J.C.2    Freund, G.G.3    Johnson, R.W.4    Kelley, K.W.5
  • 41
    • 0035038172 scopus 로고    scopus 로고
    • Cytokine-induced sickness behavior: mechanisms and implications
    • Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y Acad Sci (2001) 933(1):222–34.10.1111/j.1749-6632.2001.tb05827.x
    • (2001) Ann N Y Acad Sci , vol.933 , Issue.1 , pp. 222-234
    • Dantzer, R.1
  • 42
    • 84926640592 scopus 로고    scopus 로고
    • Glucose metabolism regulates T cell activation, differentiation, and functions
    • 25657648
    • Palmer CS, Ostrowski M, Balderson B, Christian N, Crowe SM. Glucose metabolism regulates T cell activation, differentiation, and functions. Front Immunol (2015) 6:1.10.3389/fimmu.2015.0000125657648
    • (2015) Front Immunol , vol.6 , pp. 1
    • Palmer, C.S.1    Ostrowski, M.2    Balderson, B.3    Christian, N.4    Crowe, S.M.5
  • 43
    • 84885670616 scopus 로고    scopus 로고
    • Fueling immunity: insights into metabolism and lymphocyte function
    • 24115444
    • Pearce EL, Poffenberger MC, Chang CH, Jones RG. Fueling immunity: insights into metabolism and lymphocyte function. Science (2013) 342(6155):1242454.10.1126/science.124245424115444
    • (2013) Science , vol.342 , Issue.6155 , pp. 1242454
    • Pearce, E.L.1    Poffenberger, M.C.2    Chang, C.H.3    Jones, R.G.4
  • 44
    • 79953172571 scopus 로고    scopus 로고
    • Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
    • 21317389
    • Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol (2011) 186(6):3299–303.10.4049/jimmunol.100361321317389
    • (2011) J Immunol , vol.186 , Issue.6 , pp. 3299-3303
    • Michalek, R.D.1    Gerriets, V.A.2    Jacobs, S.R.3    Macintyre, A.N.4    MacIver, N.J.5    Mason, E.F.6
  • 45
    • 50249163771 scopus 로고    scopus 로고
    • Malnutrition as an enteric infectious disease with long-term effects on child development
    • 18752473
    • Guerrant RL, Oriá RB, Moore SR, Oriá MO, Lima AA. Malnutrition as an enteric infectious disease with long-term effects on child development. Nutr Rev (2008) 66(9):487–505.10.1111/j.1753-4887.2008.00082.x18752473
    • (2008) Nutr Rev , vol.66 , Issue.9 , pp. 487-505
    • Guerrant, R.L.1    Oriá, R.B.2    Moore, S.R.3    Oriá, M.O.4    Lima, A.A.5
  • 46
    • 84874565215 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptor gamma in immune responses to enteroaggregative Escherichia coli infection
    • Philipson CW, Bassaganya-Riera J, Viladomiu M, Pedragosa M, Guerrant RL, Roche JK, et al. The role of peroxisome proliferator-activated receptor gamma in immune responses to enteroaggregative Escherichia coli infection. PLoS One (2013) 8(2):e57812.10.1371/journal.pone.0057812
    • (2013) PLoS One , vol.8 , Issue.2 , pp. e57812
    • Philipson, C.W.1    Bassaganya-Riera, J.2    Viladomiu, M.3    Pedragosa, M.4    Guerrant, R.L.5    Roche, J.K.6
  • 47
    • 84880477221 scopus 로고    scopus 로고
    • Animal models of enteroaggregative Escherichia coli infection
    • Philipson CW, Bassaganya-Riera J, Hontecillas R. Animal models of enteroaggregative Escherichia coli infection. Gut Microbes (2013) 4(4):281–91.10.4161/gmic.24826
    • (2013) Gut Microbes , vol.4 , Issue.4 , pp. 281-291
    • Philipson, C.W.1    Bassaganya-Riera, J.2    Hontecillas, R.3
  • 48
    • 84922031857 scopus 로고    scopus 로고
    • Zinc deficiency alters host response and pathogen virulence in a mouse model of enteroaggregative Escherichia coli-induced diarrhea
    • 25483331
    • Bolick DT, Kolling GL, Moore JH, II de Oliveira LA, Tung K, Philipson C, et al. Zinc deficiency alters host response and pathogen virulence in a mouse model of enteroaggregative Escherichia coli-induced diarrhea. Gut Microbes (2014) 5(5):618–27.10.4161/19490976.2014.96964225483331
    • (2014) Gut Microbes , vol.5 , Issue.5 , pp. 618-627
    • Bolick, D.T.1    Kolling, G.L.2    Moore, J.H.3    de Oliveira, L.A.4    Tung, K.5    Philipson, C.6
  • 49
    • 54249130383 scopus 로고    scopus 로고
    • Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention
    • 18596135
    • Wu D, Meydani SN. Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. J Leukoc Biol (2008) 84(4):900–14.10.1189/jlb.010802318596135
    • (2008) J Leukoc Biol , vol.84 , Issue.4 , pp. 900-914
    • Wu, D.1    Meydani, S.N.2
  • 50
    • 84867801979 scopus 로고    scopus 로고
    • Vitamin A and retinoic acid in T cell-related immunity
    • 23053562
    • Ross AC. Vitamin A and retinoic acid in T cell-related immunity. Am J Clin Nutr (2012) 96(5):1166S–72S.10.3945/ajcn.112.03463723053562
    • (2012) Am J Clin Nutr , vol.96 , Issue.5 , pp. 1166S-1172
    • Ross, A.C.1
  • 51
    • 84894036271 scopus 로고    scopus 로고
    • Zinc signals and immune function
    • 23804522
    • Haase H, Rink L. Zinc signals and immune function. Biofactors (2014) 40(1):27–40.10.1002/biof.111423804522
    • (2014) Biofactors , vol.40 , Issue.1 , pp. 27-40
    • Haase, H.1    Rink, L.2
  • 52
    • 3142705632 scopus 로고    scopus 로고
    • Reprogramming of the immune system during zinc deficiency
    • 15189122
    • Fraker PJ, King LE. Reprogramming of the immune system during zinc deficiency. Annu Rev Nutr (2004) 24:277–98.10.1146/annurev.nutr.24.012003.13245415189122
    • (2004) Annu Rev Nutr , vol.24 , pp. 277-298
    • Fraker, P.J.1    King, L.E.2
  • 53
    • 84907960261 scopus 로고    scopus 로고
    • Very long chain omega-3 (n-3) fatty acids and human health
    • Calder PC. Very long chain omega-3 (n-3) fatty acids and human health. Eur J Lipid Sci Technol (2014) 116(10):1280–300.10.1002/ejlt.201400025
    • (2014) Eur J Lipid Sci Technol , vol.116 , Issue.10 , pp. 1280-1300
    • Calder, P.C.1
  • 54
    • 84858243360 scopus 로고    scopus 로고
    • Mechanisms of action of (n-3) fatty acids
    • 22279140
    • Calder PC. Mechanisms of action of (n-3) fatty acids. J Nutr (2012) 142(3):592S–9S.10.3945/jn.111.15525922279140
    • (2012) J Nutr , vol.142 , Issue.3 , pp. 592S-599
    • Calder, P.C.1
  • 55
    • 84939621718 scopus 로고    scopus 로고
    • Functional roles of fatty acids and their effects on human health
    • 26177664
    • Calder PC. Functional roles of fatty acids and their effects on human health. JPEN J Parenter Enteral Nutr (2015) 39(1 Suppl):18S–32S.10.1177/014860711559598026177664
    • (2015) JPEN J Parenter Enteral Nutr , vol.39 , Issue.1 Suppl , pp. 18S-32S
    • Calder, P.C.1
  • 56
    • 0036305526 scopus 로고    scopus 로고
    • Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid
    • 12097686
    • Hontecillas R, Wannemeulher MJ, Zimmerman DR, Hutto DL, Wilson JH, Ahn DU, et al. Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid. J Nutr (2002) 132(7):2019–27.12097686
    • (2002) J Nutr , vol.132 , Issue.7 , pp. 2019-2027
    • Hontecillas, R.1    Wannemeulher, M.J.2    Zimmerman, D.R.3    Hutto, D.L.4    Wilson, J.H.5    Ahn, D.U.6
  • 57
    • 4444280899 scopus 로고    scopus 로고
    • Activation of PPAR γ and δ by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease
    • Bassaganya-Riera J, Reynolds K, Martino-Catt S, Cui Y, Hennighausen L, Gonzalez F, et al. Activation of PPAR γ and δ by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology (2004) 127(3):777–91.10.1053/j.gastro.2004.06.049
    • (2004) Gastroenterology , vol.127 , Issue.3 , pp. 777-791
    • Bassaganya-Riera, J.1    Reynolds, K.2    Martino-Catt, S.3    Cui, Y.4    Hennighausen, L.5    Gonzalez, F.6
  • 58
    • 33744937585 scopus 로고    scopus 로고
    • CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD
    • 16698153
    • Bassaganya-Riera J, Hontecillas R. CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD. Clin Nutr (2006) 25(3):454–65.10.1016/j.clnu.2005.12.00816698153
    • (2006) Clin Nutr , vol.25 , Issue.3 , pp. 454-465
    • Bassaganya-Riera, J.1    Hontecillas, R.2
  • 59
    • 77249105986 scopus 로고    scopus 로고
    • Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARγ
    • Evans NP, Misyak SA, Schmelz EM, Guri AJ, Hontecillas R, Bassaganya-Riera J. Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARγ. J Nutr (2010) 140(3):515–21.10.3945/jn.109.115642
    • (2010) J Nutr , vol.140 , Issue.3 , pp. 515-521
    • Evans, N.P.1    Misyak, S.A.2    Schmelz, E.M.3    Guri, A.J.4    Hontecillas, R.5    Bassaganya-Riera, J.6
  • 60
    • 0141863439 scopus 로고    scopus 로고
    • Conjugated linoleic acid ameliorates viral infectivity in a pig model of virally induced immunosuppression
    • 14519812
    • Bassaganya-Riera J, Pogranichniy RM, Jobgen SC, Halbur PG, Yoon KJ, O’Shea M, et al. Conjugated linoleic acid ameliorates viral infectivity in a pig model of virally induced immunosuppression. J Nutr (2003) 133(10):3204–14.14519812
    • (2003) J Nutr , vol.133 , Issue.10 , pp. 3204-3214
    • Bassaganya-Riera, J.1    Pogranichniy, R.M.2    Jobgen, S.C.3    Halbur, P.G.4    Yoon, K.J.5    O’Shea, M.6
  • 61
    • 0037203801 scopus 로고    scopus 로고
    • Long-term influence of lipid nutrition on the induction of CD8+ responses to viral or bacterial antigens
    • Bassaganya-Riera J, Hontecillas R, Zimmerman DR, Wannemuehler MJ. Long-term influence of lipid nutrition on the induction of CD8+ responses to viral or bacterial antigens. Vaccine (2002) 20(9):1435–44.10.1016/S0264-410X(01)00465-0
    • (2002) Vaccine , vol.20 , Issue.9 , pp. 1435-1444
    • Bassaganya-Riera, J.1    Hontecillas, R.2    Zimmerman, D.R.3    Wannemuehler, M.J.4
  • 62
    • 84866613234 scopus 로고    scopus 로고
    • Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn’s disease
    • 22521469
    • Bassaganya-Riera J, Hontecillas R, Horne WT, Sandridge M, Herfarth HH, Bloomfeld R, et al. Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn’s disease. Clin Nutr (2012) 31(5):721–7.10.1016/j.clnu.2012.03.00222521469
    • (2012) Clin Nutr , vol.31 , Issue.5 , pp. 721-727
    • Bassaganya-Riera, J.1    Hontecillas, R.2    Horne, W.T.3    Sandridge, M.4    Herfarth, H.H.5    Bloomfeld, R.6
  • 64
    • 33846566783 scopus 로고    scopus 로고
    • Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets
    • 17000034
    • Guri AJ, Hontecillas R, Si H, Liu D, Bassaganya-Riera J. Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets. Clin Nutr (2007) 26(1):107–16.10.1016/j.clnu.2006.07.00817000034
    • (2007) Clin Nutr , vol.26 , Issue.1 , pp. 107-116
    • Guri, A.J.1    Hontecillas, R.2    Si, H.3    Liu, D.4    Bassaganya-Riera, J.5
  • 65
    • 77955920362 scopus 로고    scopus 로고
    • Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration
    • 20236740
    • Guri AJ, Hontecillas R, Bassaganya-Riera J. Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration. Clin Nutr (2010) 29(6):824–31.10.1016/j.clnu.2010.02.00920236740
    • (2010) Clin Nutr , vol.29 , Issue.6 , pp. 824-831
    • Guri, A.J.1    Hontecillas, R.2    Bassaganya-Riera, J.3
  • 66
    • 78249263857 scopus 로고    scopus 로고
    • Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall
    • 20092994
    • Guri AJ, Misyak SA, Hontecillas R, Hasty A, Liu D, Si H, et al. Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall. J Nutr Biochem (2010) 21(12):1178–85.10.1016/j.jnutbio.2009.10.00320092994
    • (2010) J Nutr Biochem , vol.21 , Issue.12 , pp. 1178-1185
    • Guri, A.J.1    Misyak, S.A.2    Hontecillas, R.3    Hasty, A.4    Liu, D.5    Si, H.6
  • 67
    • 78951490677 scopus 로고    scopus 로고
    • Abscisic acid regulates inflammation via ligand-binding domain-independent activation of peroxisome proliferator-activated receptor γ
    • Bassaganya-Riera J, Guri AJ, Lu P, Climent M, Carbo A, Sobral BW, et al. Abscisic acid regulates inflammation via ligand-binding domain-independent activation of peroxisome proliferator-activated receptor γ. J Biol Chem (2011) 286(4):2504–16.10.1074/jbc.M110.160077
    • (2011) J Biol Chem , vol.286 , Issue.4 , pp. 2504-2516
    • Bassaganya-Riera, J.1    Guri, A.J.2    Lu, P.3    Climent, M.4    Carbo, A.5    Sobral, B.W.6
  • 68
    • 84878015761 scopus 로고    scopus 로고
    • Dietary abscisic acid ameliorates influenza-virus-associated disease and pulmonary immunopathology through a PPARγ-dependent mechanism
    • 22995385
    • Hontecillas R, Roberts PC, Carbo A, Vives C, Horne WT, Genis S, et al. Dietary abscisic acid ameliorates influenza-virus-associated disease and pulmonary immunopathology through a PPARγ-dependent mechanism. J Nutr Biochem (2013) 24(6):1019–27.10.1016/j.jnutbio.2012.07.01022995385
    • (2013) J Nutr Biochem , vol.24 , Issue.6 , pp. 1019-1027
    • Hontecillas, R.1    Roberts, P.C.2    Carbo, A.3    Vives, C.4    Horne, W.T.5    Genis, S.6
  • 69
    • 84973430336 scopus 로고    scopus 로고
    • Microgram amounts of abscisic acid in fruit extracts improve glucose tolerance and reduce insulinemia in rats and in humans
    • 26243865
    • Magnone M, Ameri P, Salis A, Andraghetti G, Emionite L, Murialdo G, et al. Microgram amounts of abscisic acid in fruit extracts improve glucose tolerance and reduce insulinemia in rats and in humans. FASEB J (2015) 29(12):4783–93.10.1096/fj.15-27773126243865
    • (2015) FASEB J , vol.29 , Issue.12 , pp. 4783-4793
    • Magnone, M.1    Ameri, P.2    Salis, A.3    Andraghetti, G.4    Emionite, L.5    Murialdo, G.6
  • 70
    • 0030406364 scopus 로고    scopus 로고
    • Nutrition and the immune system: a review of nutrient-nutrient interactions
    • Kubena KS, McMurray DN. Nutrition and the immune system: a review of nutrient-nutrient interactions. J Am Diet Assoc (1996) 96(11):1156–64.10.1016/S0002-8223(96)00297-0
    • (1996) J Am Diet Assoc , vol.96 , Issue.11 , pp. 1156-1164
    • Kubena, K.S.1    McMurray, D.N.2
  • 71
    • 84948406851 scopus 로고    scopus 로고
    • Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes
    • 26608884
    • Lacroix S, Lauria M, Scott-Boyer MP, Marchetti L, Priami C, Caberlotto L. Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes. Genes Nutr (2015) 10(6):58.10.1007/s12263-015-0508-926608884
    • (2015) Genes Nutr , vol.10 , Issue.6 , pp. 58
    • Lacroix, S.1    Lauria, M.2    Scott-Boyer, M.P.3    Marchetti, L.4    Priami, C.5    Caberlotto, L.6
  • 72
    • 66549083800 scopus 로고    scopus 로고
    • Enabling a systems biology approach to immunology: focus on innate immunity
    • 19428301
    • Gardy JL, Lynn DJ, Brinkman FS, Hancock RE. Enabling a systems biology approach to immunology: focus on innate immunity. Trends Immunol (2009) 30(6):249–62.10.1016/j.it.2009.03.00919428301
    • (2009) Trends Immunol , vol.30 , Issue.6 , pp. 249-262
    • Gardy, J.L.1    Lynn, D.J.2    Brinkman, F.S.3    Hancock, R.E.4
  • 73
    • 1842483155 scopus 로고    scopus 로고
    • Nutritional genomics: the next frontier in the postgenomic era
    • 14726599
    • Kaput J, Rodriguez RL. Nutritional genomics: the next frontier in the postgenomic era. Physiol Genomics (2004) 16(2):166–77.10.1152/physiolgenomics.00107.200314726599
    • (2004) Physiol Genomics , vol.16 , Issue.2 , pp. 166-177
    • Kaput, J.1    Rodriguez, R.L.2
  • 75
    • 84875387739 scopus 로고    scopus 로고
    • Metabolomics in nutrition research: current status and perspectives
    • 23514174
    • Brennan L. Metabolomics in nutrition research: current status and perspectives. Biochem Soc Trans (2013) 41(2):670–3.10.1042/BST2012035023514174
    • (2013) Biochem Soc Trans , vol.41 , Issue.2 , pp. 670-673
    • Brennan, L.1
  • 76
    • 77950493668 scopus 로고    scopus 로고
    • An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach
    • 20181810
    • Bakker GC, van Erk MJ, Pellis L, Wopereis S, Rubingh CM, Cnubben NH, et al. An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. Am J Clin Nutr (2010) 91(4):1044–59.10.3945/ajcn.2009.2882220181810
    • (2010) Am J Clin Nutr , vol.91 , Issue.4 , pp. 1044-1059
    • Bakker, G.C.1    van Erk, M.J.2    Pellis, L.3    Wopereis, S.4    Rubingh, C.M.5    Cnubben, N.H.6
  • 77
    • 84909632141 scopus 로고    scopus 로고
    • Computational modeling of heterogeneity and function of CD4+ T cells
    • 25364738
    • Carbo A, Hontecillas R, Andrew T, Eden K, Mei Y, Hoops S, et al. Computational modeling of heterogeneity and function of CD4+ T cells. Front Cell Dev Biol (2014) 2:31.10.3389/fcell.2014.0003125364738
    • (2014) Front Cell Dev Biol , vol.2 , pp. 31
    • Carbo, A.1    Hontecillas, R.2    Andrew, T.3    Eden, K.4    Mei, Y.5    Hoops, S.6
  • 78
    • 84961566740 scopus 로고    scopus 로고
    • Multiscale modeling of mucosal immune responses
    • 26329787
    • Mei Y, Abedi V, Carbo A, Zhang X, Lu P, Philipson C, et al. Multiscale modeling of mucosal immune responses. BMC Bioinformatics (2015) 16(Suppl 12):S2.10.1186/1471-2105-16-S12-S226329787
    • (2015) BMC Bioinformatics , vol.16 , pp. S2
    • Mei, Y.1    Abedi, V.2    Carbo, A.3    Zhang, X.4    Lu, P.5    Philipson, C.6
  • 79
    • 77952954251 scopus 로고    scopus 로고
    • Model of colonic inflammation: immune modulatory mechanisms in inflammatory bowel disease
    • 20362587
    • Wendelsdorf K, Bassaganya-Riera J, Hontecillas R, Eubank S. Model of colonic inflammation: immune modulatory mechanisms in inflammatory bowel disease. J Theor Biol (2010) 264(4):1225–39.10.1016/j.jtbi.2010.03.02720362587
    • (2010) J Theor Biol , vol.264 , Issue.4 , pp. 1225-1239
    • Wendelsdorf, K.1    Bassaganya-Riera, J.2    Hontecillas, R.3    Eubank, S.4
  • 80
    • 81355123249 scopus 로고    scopus 로고
    • Software for systems biology: from tools to integrated platforms
    • 22048662
    • Ghosh S, Matsuoka Y, Asai Y, Hsin KY, Kitano H. Software for systems biology: from tools to integrated platforms. Nat Rev Genet (2011) 12(12):821–32.10.1038/nrg309622048662
    • (2011) Nat Rev Genet , vol.12 , Issue.12 , pp. 821-832
    • Ghosh, S.1    Matsuoka, Y.2    Asai, Y.3    Hsin, K.Y.4    Kitano, H.5
  • 82
    • 84929376895 scopus 로고    scopus 로고
    • Modeling biology spanning different scales: an open challenge
    • 25143952
    • Castiglione F, Pappalardo F, Bianca C, Russo G, Motta S. Modeling biology spanning different scales: an open challenge. Biomed Res Int (2014) 2014:902545.10.1155/2014/90254525143952
    • (2014) Biomed Res Int , vol.2014 , pp. 902545
    • Castiglione, F.1    Pappalardo, F.2    Bianca, C.3    Russo, G.4    Motta, S.5
  • 83
    • 84918767987 scopus 로고    scopus 로고
    • A multiscale model of interleukin-6-mediated immune regulation in Crohn’s disease and its application in drug discovery and development
    • 24402116
    • Dwivedi G, Fitz L, Hegen M, Martin SW, Harrold J, Heatherington A, et al. A multiscale model of interleukin-6-mediated immune regulation in Crohn’s disease and its application in drug discovery and development. CPT Pharmacometrics Syst Pharmacol (2014) 3:e89.10.1038/psp.2013.6424402116
    • (2014) CPT Pharmacometrics Syst Pharmacol , vol.3 , pp. e89
    • Dwivedi, G.1    Fitz, L.2    Hegen, M.3    Martin, S.W.4    Harrold, J.5    Heatherington, A.6
  • 85
    • 84872511963 scopus 로고    scopus 로고
    • Bridging the scales: semantic integration of quantitative SBML in graphical multi-cellular models and simulations with EPISIM and COPASI
    • 23162085
    • Sütterlin T, Kolb C, Dickhaus H, Jäger D, Grabe N. Bridging the scales: semantic integration of quantitative SBML in graphical multi-cellular models and simulations with EPISIM and COPASI. Bioinformatics (2013) 29(2):223–9.10.1093/bioinformatics/bts65923162085
    • (2013) Bioinformatics , vol.29 , Issue.2 , pp. 223-229
    • Sütterlin, T.1    Kolb, C.2    Dickhaus, H.3    Jäger, D.4    Grabe, N.5
  • 87
    • 0037342537 scopus 로고    scopus 로고
    • The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models
    • 12611808
    • Hucka M, Finney A, Sauro HM, Bolouri H, Doyle JC, Kitano H, et al. The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics (2003) 19(4):524–31.10.1093/bioinformatics/btg01512611808
    • (2003) Bioinformatics , vol.19 , Issue.4 , pp. 524-531
    • Hucka, M.1    Finney, A.2    Sauro, H.M.3    Bolouri, H.4    Doyle, J.C.5    Kitano, H.6
  • 89
    • 48349143030 scopus 로고    scopus 로고
    • Biomedical ontologies in action: role in knowledge management, data integration and decision support
    • 18660879
    • Bodenreider O. Biomedical ontologies in action: role in knowledge management, data integration and decision support. Yearb Med Inform (2008):67–79.18660879
    • (2008) Yearb Med Inform , pp. 67-79
    • Bodenreider, O.1
  • 90
    • 0004234233 scopus 로고    scopus 로고
    • Available from
    • Information NCFB. Medical Subject Headings. Available from: http://www.ncbi.nlm.nih.gov/mesh
    • Medical Subject Headings
  • 91
    • 0345863927 scopus 로고    scopus 로고
    • The unified medical language system (UMLS): integrating biomedical terminology
    • 14681409
    • Bodenreider O. The unified medical language system (UMLS): integrating biomedical terminology. Nucleic Acids Res (2004) 32:D267–70.10.1093/nar/gkh06114681409
    • (2004) Nucleic Acids Res , vol.32 , pp. D267-D270
    • Bodenreider, O.1
  • 92
    • 84859267371 scopus 로고    scopus 로고
    • Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery
    • 21948793
    • Zhu F, Shi Z, Qin C, Tao L, Liu X, Xu F, et al. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res (2012) 40(Database issue):D1128–36.10.1093/nar/gkr79721948793
    • (2012) Nucleic Acids Res , vol.40 , Issue.Database issue , pp. D1128-D1136
    • Zhu, F.1    Shi, Z.2    Qin, C.3    Tao, L.4    Liu, X.5    Xu, F.6
  • 93
    • 84899858598 scopus 로고    scopus 로고
    • Construction and analysis of a human hepatotoxicity database suitable for QSAR modeling using post-market safety data
    • 24721472
    • Zhu X, Kruhlak NL. Construction and analysis of a human hepatotoxicity database suitable for QSAR modeling using post-market safety data. Toxicology (2014) 321:62–72.10.1016/j.tox.2014.03.00924721472
    • (2014) Toxicology , vol.321 , pp. 62-72
    • Zhu, X.1    Kruhlak, N.L.2
  • 94
    • 77949497071 scopus 로고    scopus 로고
    • DCDB: drug combination database
    • 20031966
    • Liu Y, Hu B, Fu C, Chen X. DCDB: drug combination database. Bioinformatics (2010) 26(4):587–8.10.1093/bioinformatics/btp69720031966
    • (2010) Bioinformatics , vol.26 , Issue.4 , pp. 587-588
    • Liu, Y.1    Hu, B.2    Fu, C.3    Chen, X.4
  • 95
    • 55649101632 scopus 로고    scopus 로고
    • FDA toxicity databases and real-time data entry
    • 18656494
    • Arvidson KB. FDA toxicity databases and real-time data entry. Toxicol Appl Pharmacol (2008) 233(1):17–9.10.1016/j.taap.2007.12.03318656494
    • (2008) Toxicol Appl Pharmacol , vol.233 , Issue.1 , pp. 17-19
    • Arvidson, K.B.1
  • 96
    • 84930199524 scopus 로고    scopus 로고
    • White adipose tissue reference network: a knowledge resource for exploring health-relevant relations
    • 25466819
    • Kelder T, Summer G, Caspers M, van Schothorst EM, Keijer J, Duivenvoorde L, et al. White adipose tissue reference network: a knowledge resource for exploring health-relevant relations. Genes Nutr (2015) 10:439.10.1007/s12263-014-0439-x25466819
    • (2015) Genes Nutr , vol.10 , pp. 439
    • Kelder, T.1    Summer, G.2    Caspers, M.3    van Schothorst, E.M.4    Keijer, J.5    Duivenvoorde, L.6
  • 98
    • 84940666251 scopus 로고    scopus 로고
    • Supervised learning methods in modeling of CD4+ T cell heterogeneity
    • 26339293
    • Lu P, Abedi V, Mei Y, Hontecillas R, Hoops S, Carbo A, et al. Supervised learning methods in modeling of CD4+ T cell heterogeneity. BioData Min (2015) 8:27.10.1186/s13040-015-0060-626339293
    • (2015) BioData Min , vol.8 , pp. 27
    • Lu, P.1    Abedi, V.2    Mei, Y.3    Hontecillas, R.4    Hoops, S.5    Carbo, A.6
  • 101
    • 84947416904 scopus 로고    scopus 로고
    • Modeling the regulatory mechanisms by which NLRX1 modulates innate immune responses to Helicobacter pylori infection
    • 26367386
    • Philipson CW, Bassaganya-Riera J, Viladomiu M, Kronsteiner B, Abedi V, Hoops S, et al. Modeling the regulatory mechanisms by which NLRX1 modulates innate immune responses to Helicobacter pylori infection. PLoS One (2015) 10(9):e0137839.10.1371/journal.pone.013783926367386
    • (2015) PLoS One , vol.10 , Issue.9 , pp. e0137839
    • Philipson, C.W.1    Bassaganya-Riera, J.2    Viladomiu, M.3    Kronsteiner, B.4    Abedi, V.5    Hoops, S.6
  • 102
    • 84876806691 scopus 로고    scopus 로고
    • Dynamic regulatory network controlling TH17 cell differentiation
    • 23467089
    • Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, et al. Dynamic regulatory network controlling TH17 cell differentiation. Nature (2013) 496(7446):461–8.10.1038/nature1198123467089
    • (2013) Nature , vol.496 , Issue.7446 , pp. 461-468
    • Yosef, N.1    Shalek, A.K.2    Gaublomme, J.T.3    Jin, H.4    Lee, Y.5    Awasthi, A.6
  • 111
    • 34548304745 scopus 로고    scopus 로고
    • In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling
    • 17549047
    • Ekins S, Mestres J, Testa B. In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling. Br J Pharmacol (2007) 152(1):9–20.10.1038/sj.bjp.070730517549047
    • (2007) Br J Pharmacol , vol.152 , Issue.1 , pp. 9-20
    • Ekins, S.1    Mestres, J.2    Testa, B.3
  • 112
    • 84927681963 scopus 로고    scopus 로고
    • The future is now: model-based clinical trial design for Alzheimer’s disease
    • Romero K, Ito K, Rogers JA, Polhamus D, Qiu R, Stephenson D, et al. The future is now: model-based clinical trial design for Alzheimer’s disease. Clin Pharmacol Ther (2015) 97(3):210–4.10.1002/cpt.16
    • (2015) Clin Pharmacol Ther , vol.97 , Issue.3 , pp. 210-214
    • Romero, K.1    Ito, K.2    Rogers, J.A.3    Polhamus, D.4    Qiu, R.5    Stephenson, D.6
  • 113
    • 84929500900 scopus 로고    scopus 로고
    • Trauma in silico: individual-specific mathematical models and virtual clinical populations
    • 25925680
    • Brown D, Namas RA, Almahmoud K, Zaaqoq A, Sarkar J, Barclay DA, et al. Trauma in silico: individual-specific mathematical models and virtual clinical populations. Sci Transl Med (2015) 7(285):ra61–285.10.1126/scitranslmed.aaa363625925680
    • (2015) Sci Transl Med , vol.7 , Issue.285 , pp. ra61-ra285
    • Brown, D.1    Namas, R.A.2    Almahmoud, K.3    Zaaqoq, A.4    Sarkar, J.5    Barclay, D.A.6
  • 114
    • 84864722033 scopus 로고    scopus 로고
    • Gut microbiota composition correlates with diet and health in the elderly
    • 22797518
    • Claesson MJ, Jeffery IB, Conde S, Power SE, O’Connor EM, Cusack S, et al. Gut microbiota composition correlates with diet and health in the elderly. Nature (2012) 488(7410):178–84.10.1038/nature1131922797518
    • (2012) Nature , vol.488 , Issue.7410 , pp. 178-184
    • Claesson, M.J.1    Jeffery, I.B.2    Conde, S.3    Power, S.E.4    O’Connor, E.M.5    Cusack, S.6
  • 115
    • 79954428171 scopus 로고    scopus 로고
    • Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics
    • 20512604
    • Lu P, Bevan DR, Lewis SN, Hontecillas R, Bassaganya-Riera J. Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics. J Mol Model (2011) 17(3):543–53.10.1007/s00894-010-0748-y20512604
    • (2011) J Mol Model , vol.17 , Issue.3 , pp. 543-553
    • Lu, P.1    Bevan, D.R.2    Lewis, S.N.3    Hontecillas, R.4    Bassaganya-Riera, J.5
  • 116
    • 84969662023 scopus 로고    scopus 로고
    • Mo1691 lanthionine synthetase C-like receptor 2 (LANCL2): a novel therapeutic target for inflammatory bowel disease
    • Carbo A, Hontecillas R, Cooper J, Gandour RD, Ehrich M, Bassaganya-Riera J. Mo1691 lanthionine synthetase C-like receptor 2 (LANCL2): a novel therapeutic target for inflammatory bowel disease. Gastroenterology (2015) 148(4):S–686.10.1016/S0016-5085(15)32321-0
    • (2015) Gastroenterology , vol.148 , Issue.4 , pp. 686
    • Carbo, A.1    Hontecillas, R.2    Cooper, J.3    Gandour, R.D.4    Ehrich, M.5    Bassaganya-Riera, J.6
  • 117
    • 84905276988 scopus 로고    scopus 로고
    • Individual diet has sex-dependent effects on vertebrate gut microbiota
    • 25072318
    • Bolnick DI, Snowberg LK, Hirsch PE, Lauber CL, Org E, Parks B, et al. Individual diet has sex-dependent effects on vertebrate gut microbiota. Nat Commun (2014) 5:4500.10.1038/ncomms550025072318
    • (2014) Nat Commun , vol.5 , pp. 4500
    • Bolnick, D.I.1    Snowberg, L.K.2    Hirsch, P.E.3    Lauber, C.L.4    Org, E.5    Parks, B.6
  • 118
    • 84878979335 scopus 로고    scopus 로고
    • Biology: the big challenges of big data
    • Marx V. Biology: the big challenges of big data. Nature (2013) 498(7453):255–60.10.1038/498255a
    • (2013) Nature , vol.498 , Issue.7453 , pp. 255-260
    • Marx, V.1
  • 119
    • 84919389078 scopus 로고    scopus 로고
    • Challenges of big data analysis
    • 25419469
    • Fan J, Han F, Liu H. Challenges of big data analysis. Natl Sci Rev (2014) 1(2):293–314.10.1093/nsr/nwt03225419469
    • (2014) Natl Sci Rev , vol.1 , Issue.2 , pp. 293-314
    • Fan, J.1    Han, F.2    Liu, H.3
  • 121
    • 33845368513 scopus 로고    scopus 로고
    • COPASI – a complex pathway simulator
    • Hoops S, Sahle S, Gauges R, Lee C, Pahle J, Simus N, et al. COPASI – a complex pathway simulator. Bioinformatics (2006) 22(24):3067–74.10.1093/bioinformatics/btl485
    • (2006) Bioinformatics , vol.22 , Issue.24 , pp. 3067-3074
    • Hoops, S.1    Sahle, S.2    Gauges, R.3    Lee, C.4    Pahle, J.5    Simus, N.6
  • 124
    • 84876915404 scopus 로고    scopus 로고
    • Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity
    • 23592971
    • Carbo A, Hontecillas R, Kronsteiner B, Viladomiu M, Pedragosa M, Lu P, et al. Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity. PLoS Comput Biol (2013) 9(4):e1003027.10.1371/journal.pcbi.100302723592971
    • (2013) PLoS Comput Biol , vol.9 , Issue.4 , pp. e1003027
    • Carbo, A.1    Hontecillas, R.2    Kronsteiner, B.3    Viladomiu, M.4    Pedragosa, M.5    Lu, P.6
  • 125
    • 85003047735 scopus 로고    scopus 로고
    • Systems modeling of the role of IL-21 in the maintenance of effector CD4+ T cell responses during Helicobacter pylori infection
    • Carbo A, Olivares-Villagómez D, Hontecillas R, Bassaganya-Riera J, Chaturvedi R, Piazuelo MB, et al. Systems modeling of the role of IL-21 in the maintenance of effector CD4+ T cell responses during Helicobacter pylori infection. MBio (2014) 5(4):e1243–1214.10.1128/mBio.01243-14
    • (2014) MBio , vol.5 , Issue.4 , pp. e1243-1214
    • Carbo, A.1    Olivares-Villagómez, D.2    Hontecillas, R.3    Bassaganya-Riera, J.4    Chaturvedi, R.5    Piazuelo, M.B.6
  • 126
    • 84883495378 scopus 로고    scopus 로고
    • Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection
    • 24039925
    • Carbo A, Bassaganya-Riera J, Pedragosa M, Viladomiu M, Marathe M, Eubank S, et al. Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection. PLoS One (2013) 8(9):e73365.10.1371/journal.pone.007336524039925
    • (2013) PLoS One , vol.8 , Issue.9 , pp. e73365
    • Carbo, A.1    Bassaganya-Riera, J.2    Pedragosa, M.3    Viladomiu, M.4    Marathe, M.5    Eubank, S.6
  • 127
    • 84884373415 scopus 로고    scopus 로고
    • Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses
    • 23897614
    • Kronsteiner B, Bassaganya-Riera J, Philipson C, Viladomiu M, Carbo A, Pedragosa M, et al. Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses. Infect Immun (2013) 81(10):3803–13.10.1128/IAI.00660-1323897614
    • (2013) Infect Immun , vol.81 , Issue.10 , pp. 3803-3813
    • Kronsteiner, B.1    Bassaganya-Riera, J.2    Philipson, C.3    Viladomiu, M.4    Carbo, A.5    Pedragosa, M.6
  • 128
    • 84964313428 scopus 로고    scopus 로고
    • Novel insights on the role of CD8+ T cells and cytotoxic responses during Helicobacter pylori infection
    • 24755940
    • Kronsteiner B, Bassaganya-Riera J, Philipson N, Hontecillas R. Novel insights on the role of CD8+ T cells and cytotoxic responses during Helicobacter pylori infection. Gut Microbes (2014) 5(3):357–62.10.4161/gmic.2889924755940
    • (2014) Gut Microbes , vol.5 , Issue.3 , pp. 357-362
    • Kronsteiner, B.1    Bassaganya-Riera, J.2    Philipson, N.3    Hontecillas, R.4
  • 129
    • 84880477221 scopus 로고    scopus 로고
    • Animal models of enteroaggregative Escherichia coli infection
    • 23680797
    • Philipson CW, Bassaganya-Riera J, Hontecillas R. Animal models of enteroaggregative Escherichia coli infection. Gut Microbes (2013) 4(4):281–91.10.4161/gmic.2482623680797
    • (2013) Gut Microbes , vol.4 , Issue.4 , pp. 281-291
    • Philipson, C.W.1    Bassaganya-Riera, J.2    Hontecillas, R.3
  • 130
    • 84877862711 scopus 로고    scopus 로고
    • Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide
    • 23475903
    • Bolick DT, Roche JK, Hontecillas R, Bassaganya-Riera J, Nataro JP, Guerrant RL. Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide. J Med Microbiol (2013) 62(Pt 6):896–905.10.1099/jmm.0.046300-023475903
    • (2013) J Med Microbiol , vol.62 , pp. 896-905
    • Bolick, D.T.1    Roche, J.K.2    Hontecillas, R.3    Bassaganya-Riera, J.4    Nataro, J.P.5    Guerrant, R.L.6
  • 132
    • 84941733052 scopus 로고    scopus 로고
    • Interactive big data resource to elucidate human immune pathways and diseases
    • 26362267
    • Gorenshteyn D, Zaslavsky E, Fribourg M, Park CY, Wong AK, Tadych A, et al. Interactive big data resource to elucidate human immune pathways and diseases. Immunity (2015) 43(3):605–14.10.1016/j.immuni.2015.08.01426362267
    • (2015) Immunity , vol.43 , Issue.3 , pp. 605-614
    • Gorenshteyn, D.1    Zaslavsky, E.2    Fribourg, M.3    Park, C.Y.4    Wong, A.K.5    Tadych, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.