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Volumn 2014, Issue , 2014, Pages

Modeling biology spanning different scales: An open challenge

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MODEL; DNA MODIFICATION; GENE EXPRESSION; HUMAN; IMMUNE SYSTEM; INTRACELLULAR SIGNALING; MATHEMATICAL MODEL; QUANTUM MECHANICS; REVIEW; SYSTEMS BIOLOGY; BIOLOGY;

EID: 84929376895     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/902545     Document Type: Review
Times cited : (58)

References (78)
  • 1
    • 84929307635 scopus 로고    scopus 로고
    • Simplicity
    • Stanford University, Stanford, Calif, USA
    • A. Baker, "Simplicity", in Stanford Encyclopedia of Philosophy, Stanford University, Stanford, Calif, USA, 2010.
    • (2010) Stanford Encyclopedia of Philosophy
    • Baker, A.1
  • 2
    • 0028763687 scopus 로고
    • Verification, validation, and confirmation of numerical models in the earth sciences
    • N. Oreskes, K. Shrader-Frechette, and K. Belitz, "Verification, validation, and confirmation of numerical models in the earth sciences", Science, vol. 263, no. 5147, pp. 641-646, 1994.
    • (1994) Science , vol.263 , Issue.5147 , pp. 641-646
    • Oreskes, N.1    Shrader-Frechette, K.2    Belitz, K.3
  • 3
    • 0039965042 scopus 로고
    • Let's razor Occam's razor
    • D. Knowles, Ed., Cambridge University Press
    • E. Sober, "Let's razor Occam's razor", in Explanation and Its Limits, D. Knowles, Ed., pp. 73-93, Cambridge University Press, 1991.
    • (1991) Explanation and its Limits , pp. 73-93
    • Sober, E.1
  • 4
    • 0036500993 scopus 로고    scopus 로고
    • Systems biology: A brief overview
    • H. Kitano, "Systems biology: a brief overview", Science, vol. 295, no. 5560, pp. 1662-1664, 2002.
    • (2002) Science , vol.295 , Issue.5560 , pp. 1662-1664
    • Kitano, H.1
  • 5
    • 0036580169 scopus 로고    scopus 로고
    • Protein interactions: Two methods for assessment of the reliability of high throughput observations
    • C. M. Deane, Ł. Salwiński, I. Xenarios, and D. Eisenberg, "Protein interactions: two methods for assessment of the reliability of high throughput observations", Molecular & Cellular Proteomics, vol. 1, no. 5, pp. 349-356, 2002.
    • (2002) Molecular & Cellular Proteomics , vol.1 , Issue.5 , pp. 349-356
    • Deane, C.M.1    Salwiński Ł.2    Xenarios, I.3    Eisenberg, D.4
  • 7
    • 33749506763 scopus 로고    scopus 로고
    • From in vivo to in silico biology and back
    • B. diVentura, C. Lemerle, K. Michalodimitrakis, and L. Serrano, "From in vivo to in silico biology and back", Nature, vol. 443, no. 7111, pp. 527-533, 2006.
    • (2006) Nature , vol.443 , Issue.7111 , pp. 527-533
    • DiVentura, B.1    Lemerle, C.2    Michalodimitrakis, K.3    Serrano, L.4
  • 8
    • 44349185622 scopus 로고    scopus 로고
    • Implementation of a regulatory gene network to simulate the TH1/2 differentiation in an agent-basedmodel of hypersensitivity reactions
    • D. Santoni, M. Pedicini, and F. Castiglione, "Implementation of a regulatory gene network to simulate the TH1/2 differentiation in an agent-basedmodel of hypersensitivity reactions", Bioinformatics, vol. 24, no. 11, pp. 1374-1380, 2008.
    • (2008) Bioinformatics , vol.24 , Issue.11 , pp. 1374-1380
    • Santoni, D.1    Pedicini, M.2    Castiglione, F.3
  • 10
    • 33044506498 scopus 로고    scopus 로고
    • Modelling biological complexity: A physical scientist's perspective
    • P. V. Coveney and P. W. Fowler, "Modelling biological complexity: a physical scientist's perspective", Journal of the Royal Society Interface, vol. 2, no. 4, pp. 267-280, 2005.
    • (2005) Journal of the Royal Society Interface , vol.2 , Issue.4 , pp. 267-280
    • Coveney, P.V.1    Fowler, P.W.2
  • 11
    • 79951480475 scopus 로고    scopus 로고
    • Multi-scale modelling and simulation in systems biology
    • J. O. Dada and P. Mendes, "Multi-scale modelling and simulation in systems biology", Integrative Biology, vol. 3, no. 2, pp. 86-96, 2011.
    • (2011) Integrative Biology , vol.3 , Issue.2 , pp. 86-96
    • Dada, J.O.1    Mendes, P.2
  • 12
    • 64849105954 scopus 로고    scopus 로고
    • Multiscale modeling of form and function
    • A. J. Engler, P. O. Humbert, B. Wehrle-Haller, and V. M. Weaver, "Multiscale modeling of form and function", Science, vol. 324, no. 5924, pp. 208-212, 2009.
    • (2009) Science , vol.324 , Issue.5924 , pp. 208-212
    • Engler, A.J.1    Humbert, P.O.2    Wehrle-Haller, B.3    Weaver, V.M.4
  • 13
    • 36048931366 scopus 로고    scopus 로고
    • Multiscale modeling of biological pattern formation
    • R. Grima, "Multiscale modeling of biological pattern formation", Current Topics in Developmental Biology, vol. 81, pp. 435-460, 2008.
    • (2008) Current Topics in Developmental Biology , vol.81 , pp. 435-460
    • Grima, R.1
  • 15
    • 77950990922 scopus 로고    scopus 로고
    • From molecules to organisms: Towards multiscale integrated models of biological systems
    • C. Lavelle, H. Berry, G. Beslon et al., "From molecules to organisms: towards multiscale integrated models of biological systems", Theoretical Biology Insights, vol. 1, pp. 13-22, 2008.
    • (2008) Theoretical Biology Insights , vol.1 , pp. 13-22
    • Lavelle, C.1    Berry, H.2    Beslon, G.3
  • 16
    • 77950361733 scopus 로고    scopus 로고
    • Multi-scale modelling in computational biomedicine
    • P. M. A. Sloot and A. G. Hoekstra, "Multi-scale modelling in computational biomedicine", Briefings in Bioinformatics, vol. 11, no. 1, Article ID bbp038, pp. 142-152, 2010.
    • (2010) Briefings in Bioinformatics , vol.11 , Issue.1 , pp. 142-152
    • Sloot, P.M.A.1    Hoekstra, A.G.2
  • 17
    • 80053164085 scopus 로고    scopus 로고
    • OpenCMISS: A multiphysics & multi-scale computational infrastructure for the VPH/Physiome project
    • C. Bradley, A. Bowery, R. Britten et al., "OpenCMISS: a multiphysics & multi-scale computational infrastructure for the VPH/Physiome project", Progress in Biophysics and Molecular Biology, vol. 107, no. 1, pp. 32-47, 2011.
    • (2011) Progress in Biophysics and Molecular Biology , vol.107 , Issue.1 , pp. 32-47
    • Bradley, C.1    Bowery, A.2    Britten, R.3
  • 18
    • 26844519686 scopus 로고    scopus 로고
    • A strategy for integrative computational physiology
    • P. Hunter and P. Nielsen, "A strategy for integrative computational physiology", Physiology, vol. 20, no. 5, pp. 316-325, 2005.
    • (2005) Physiology , vol.20 , Issue.5 , pp. 316-325
    • Hunter, P.1    Nielsen, P.2
  • 22
    • 33847626655 scopus 로고    scopus 로고
    • Multiscale modeling in biology
    • S. Schnell, R. Grima, and P. K. Maini, "Multiscale modeling in biology", The American Scientist, vol. 95, no. 2, pp. 134-142, 2007.
    • (2007) The American Scientist , vol.95 , Issue.2 , pp. 134-142
    • Schnell, S.1    Grima, R.2    Maini, P.K.3
  • 23
    • 0037336350 scopus 로고    scopus 로고
    • Integration from proteins to organs: The physiome project
    • P. J. Hunter and T. K. Borg, "Integration from proteins to organs: the physiome project", Nature Reviews Molecular Cell Biology, vol. 4, no. 3, pp. 237-243, 2003.
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , Issue.3 , pp. 237-243
    • Hunter, P.J.1    Borg, T.K.2
  • 25
    • 84856531076 scopus 로고    scopus 로고
    • Immune systems modelling by topdown and bottom-up approaches
    • C. Bianca and M. Pennisi, "Immune systems modelling by topdown and bottom-up approaches", International Mathematical Forum, vol. 7, no. 1-4, pp. 109-128, 2012.
    • (2012) International Mathematical Forum , vol.7 , Issue.1-4 , pp. 109-128
    • Bianca, C.1    Pennisi, M.2
  • 26
    • 85008066128 scopus 로고    scopus 로고
    • The VPH-Physiome project: Standards and tools for multiscale modeling in clinical applications
    • P. J. Hunter and M. Viceconti, "The VPH-Physiome project: Standards and tools for multiscale modeling in clinical applications", IEEE Reviews in Biomedical Engineering, vol. 2, pp. 40-53, 2009.
    • (2009) IEEE Reviews in Biomedical Engineering , vol.2 , pp. 40-53
    • Hunter, P.J.1    Viceconti, M.2
  • 27
    • 84889040707 scopus 로고    scopus 로고
    • Mathematical modeling of biological systems
    • S. Motta and F. Pappalardo, "Mathematical modeling of biological systems", Briefings in Bioinformatics, vol. 14, no. 4, pp. 411-422, 2013.
    • (2013) Briefings in Bioinformatics , vol.14 , Issue.4 , pp. 411-422
    • Motta, S.1    Pappalardo, F.2
  • 28
    • 0142129344 scopus 로고
    • What everyone should know about the Belousov-Zhabotinsky reaction
    • S. A. Levin, Ed., Springer, New York, NY, USA
    • J. T. Tyson, "What everyone should know about the Belousov-Zhabotinsky reaction", in Frontiers in Mathematical Biology, S. A. Levin, Ed., pp. 569-587, Springer, New York, NY, USA, 1994.
    • (1994) Frontiers in Mathematical Biology , pp. 569-587
    • Tyson, J.T.1
  • 29
    • 0003475470 scopus 로고    scopus 로고
    • Springer, New York, NY, USA
    • J. D. Murray, Mathematical Biology Vol I and Vol II, Springer, New York, NY, USA, 2003.
    • (2003) Mathematical Biology , vol.1-2
    • Murray, J.D.1
  • 30
    • 0017030517 scopus 로고
    • A general method for numerically simulating the stochastic time evolution of coupled chemical reactions
    • D. T. Gillepsie, "A general method for numerically simulating the stochastic time evolution of coupled chemical reactions", Journal of Computational Physics, vol. 22, no. 4, pp. 403-434, 1976.
    • (1976) Journal of Computational Physics , vol.22 , Issue.4 , pp. 403-434
    • Gillepsie, D.T.1
  • 31
    • 33645429016 scopus 로고
    • Exact stochastic simulation of coupled chemical reactions
    • D. T. Gillespie, "Exact stochastic simulation of coupled chemical reactions", Journal of Physical Chemistry, vol. 81, no. 25, pp. 2340-2361, 1977.
    • (1977) Journal of Physical Chemistry , vol.81 , Issue.25 , pp. 2340-2361
    • Gillespie, D.T.1
  • 32
    • 0001177693 scopus 로고
    • Monte Carlo approach to tissue-cell populations
    • D. Drasdo, R. Kree, and J. S. McCaskill, "Monte Carlo approach to tissue-cell populations", Physical Review E, vol. 52, no. 6, pp. 6635-6657, 1995.
    • (1995) Physical Review E , vol.52 , Issue.6 , pp. 6635-6657
    • Drasdo, D.1    Kree, R.2    McCaskill, J.S.3
  • 33
    • 0034180349 scopus 로고    scopus 로고
    • Buckling instabilities of one-layered growing tissues
    • D. Drasdo, "Buckling instabilities of one-layered growing tissues", Physical Review Letters, vol. 84, no. 18, pp. 4244-4247, 2000.
    • (2000) Physical Review Letters , vol.84 , Issue.18 , pp. 4244-4247
    • Drasdo, D.1
  • 34
    • 77953771023 scopus 로고    scopus 로고
    • Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration
    • S. Hoehme, M. Brulport, A. Bauer et al., "Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration", Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 23, pp. 10371-10376, 2010.
    • (2010) Proceedings of the National Academy of Sciences of the United States of America , vol.107 , Issue.23 , pp. 10371-10376
    • Hoehme, S.1    Brulport, M.2    Bauer, A.3
  • 35
    • 0031126595 scopus 로고    scopus 로고
    • A mathematical model of circulation in the presence of the bidirectional cavopulmonary anastomosis in children with a univentricular heart
    • G. Pennati, F. Migliavacca, G. Dubini, R. Pietrabissa, and M. R. De Leval, "A mathematical model of circulation in the presence of the bidirectional cavopulmonary anastomosis in children with a univentricular heart", Medical Engineering and Physics, vol. 19, no. 3, pp. 223-234, 1997.
    • (1997) Medical Engineering and Physics , vol.19 , Issue.3 , pp. 223-234
    • Pennati, G.1    Migliavacca, F.2    Dubini, G.3    Pietrabissa, R.4    De Leval, M.R.5
  • 36
    • 0031171654 scopus 로고    scopus 로고
    • Mathematical modelling of the human foetal cardiovascular system based on Doppler ultrasound data
    • G. Pennati, M. Bellotti, and R. Fumero, "Mathematical modelling of the human foetal cardiovascular system based on Doppler ultrasound data", Medical Engineering and Physics, vol. 19, no. 4, pp. 327-335, 1997.
    • (1997) Medical Engineering and Physics , vol.19 , Issue.4 , pp. 327-335
    • Pennati, G.1    Bellotti, M.2    Fumero, R.3
  • 37
    • 0036375364 scopus 로고    scopus 로고
    • Multiscale modelling as a tool to prescribe realistic boundary conditions for the study of surgical procedures
    • K. Laganà, G. Dubini, F. Migliavacca et al., "Multiscale modelling as a tool to prescribe realistic boundary conditions for the study of surgical procedures", Biorheology, vol. 39, no. 3-4, pp. 359-364, 2002.
    • (2002) Biorheology , vol.39 , Issue.3-4 , pp. 359-364
    • Laganà, K.1    Dubini, G.2    Migliavacca, F.3
  • 38
    • 79954461933 scopus 로고    scopus 로고
    • Reactive animation: From piecemeal experimentation to reactive biological systems
    • O. Vainas, D. Harel, I. R. Cohen, and S. Efron, "Reactive animation: from piecemeal experimentation to reactive biological systems", Autoimmunity, vol. 44, no. 4, pp. 271-281, 2011.
    • (2011) Autoimmunity , vol.44 , Issue.4 , pp. 271-281
    • Vainas, O.1    Harel, D.2    Cohen, I.R.3    Efron, S.4
  • 39
    • 84864267635 scopus 로고    scopus 로고
    • Statetransition diagrams for biologists
    • H. Bersini, D. Klatzmann, A. Six, and V. Thomas-Vaslin, "Statetransition diagrams for biologists", PLoS ONE, vol. 7, no. 7, Article ID e41165, 2012.
    • (2012) PLoS ONE , vol.7 , Issue.7
    • Bersini, H.1    Klatzmann, D.2    Six, A.3    Thomas-Vaslin, V.4
  • 41
    • 0030739712 scopus 로고    scopus 로고
    • A general computational framework for modeling cellular structure and function
    • J. Schaff, C. C. Fink, B. Slepchenko, J. H. Carson, and L. M. Loew, "A general computational framework for modeling cellular structure and function", Biophysical Journal, vol. 73, no. 3, pp. 1135-1146, 1997.
    • (1997) Biophysical Journal , vol.73 , Issue.3 , pp. 1135-1146
    • Schaff, J.1    Fink, C.C.2    Slepchenko, B.3    Carson, J.H.4    Loew, L.M.5
  • 42
    • 0033515250 scopus 로고    scopus 로고
    • Buildingworking cells "in silico"
    • D. Normile, "Buildingworking cells "in silico"", Science, vol. 284, no. 5411, pp. 80-81, 1999.
    • (1999) Science , vol.284 , Issue.5411 , pp. 80-81
    • Normile, D.1
  • 43
    • 1542400036 scopus 로고    scopus 로고
    • A multialgorithm, multi-timescale method for cell simulation
    • K. Takahashi, K. Kaizu, B. Hu, and M. Tomita, "A multialgorithm, multi-timescale method for cell simulation", Bioinformatics, vol. 20, no. 4, pp. 538-546, 2004.
    • (2004) Bioinformatics , vol.20 , Issue.4 , pp. 538-546
    • Takahashi, K.1    Kaizu, K.2    Hu, B.3    Tomita, M.4
  • 46
    • 80054718671 scopus 로고    scopus 로고
    • A computational systems biology software platform for multiscale modeling and simulation: Integrating whole-body physiology, disease biology, and molecular reaction networks
    • T. Eissing, L. Kuepfer, C. Becker et al., "A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks", Frontiers in Physiology, vol. 2, article 4, 2011.
    • (2011) Frontiers in Physiology , vol.2
    • Eissing, T.1    Kuepfer, L.2    Becker, C.3
  • 47
    • 0031603269 scopus 로고    scopus 로고
    • Biological computation
    • G. Bock and J. Goode, Eds., vol. 213 of Novartis Foundation Symposium, John Wiley & Sons, London, UK
    • S. Brenner, "Biological computation", in The Limits of Reductionism in Biology, G. Bock and J. Goode, Eds., vol. 213 of Novartis Foundation Symposium, pp. 106-116, John Wiley & Sons, London, UK, 1998.
    • (1998) The Limits of Reductionism in Biology , pp. 106-116
    • Brenner, S.1
  • 48
    • 0036499997 scopus 로고    scopus 로고
    • Modeling the heart-fromgenes to cells to the whole organ
    • D. Noble, "Modeling the heart-fromgenes to cells to the whole organ", Science, vol. 295, no. 5560, pp. 1678-1682, 2002.
    • (2002) Science , vol.295 , Issue.5560 , pp. 1678-1682
    • Noble, D.1
  • 50
    • 73449130181 scopus 로고    scopus 로고
    • Nutritional systems biology modeling: From molecular mechanisms to physiology
    • A. A. de Graaf, A. P. Freidig, B. de Roos et al., "Nutritional systems biology modeling: from molecular mechanisms to physiology", PLoS Computational Biology, vol. 5, no. 11, Article ID e1000554, 2009.
    • (2009) PLoS Computational Biology , vol.5 , Issue.11
    • De Graaf, A.A.1    Freidig, A.P.2    De Roos, B.3
  • 51
    • 84870239432 scopus 로고    scopus 로고
    • Thermostatted models-multiscale analysis and tuning with real-world systems data
    • C. Bianca, "Thermostatted models-multiscale analysis and tuning with real-world systems data", Physics of Life Reviews, vol. 9, no. 4, pp. 418-425, 2012.
    • (2012) Physics of Life Reviews , vol.9 , Issue.4 , pp. 418-425
    • Bianca, C.1
  • 53
    • 77954176604 scopus 로고    scopus 로고
    • Modelling aggregation-fragmentation phenomena from kinetic to macroscopic scales
    • A. Bellouquid and C. Bianca, "Modelling aggregation-fragmentation phenomena from kinetic to macroscopic scales", Mathematical and ComputerModelling, vol. 52, no. 5-6, pp. 802-813, 2010.
    • (2010) Mathematical and ComputerModelling , vol.52 , Issue.5-6 , pp. 802-813
    • Bellouquid, A.1    Bianca, C.2
  • 54
    • 84870253633 scopus 로고    scopus 로고
    • Thermostatted kinetic equations as models for complex systems in physics and life sciences
    • C. Bianca, "Thermostatted kinetic equations as models for complex systems in physics and life sciences", Physics of Life Reviews, vol. 9, no. 4, pp. 359-399, 2012.
    • (2012) Physics of Life Reviews , vol.9 , Issue.4 , pp. 359-399
    • Bianca, C.1
  • 55
    • 78149362061 scopus 로고    scopus 로고
    • A robust model to describe the differentiation of T-helper cells
    • L. Mendoza and F. Pardo, "A robust model to describe the differentiation of T-helper cells", Theory in Biosciences, vol. 129, no. 4, pp. 283-293, 2010.
    • (2010) Theory in Biosciences , vol.129 , Issue.4 , pp. 283-293
    • Mendoza, L.1    Pardo, F.2
  • 56
    • 84879559826 scopus 로고    scopus 로고
    • The regulatory network that controls the differentiation of T lymphocytes
    • P. Martínez-Sosa and L. Mendoza, "The regulatory network that controls the differentiation of T lymphocytes", BioSystems, vol. 113, no. 2, pp. 96-103, 2013.
    • (2013) BioSystems , vol.113 , Issue.2 , pp. 96-103
    • Martínez-Sosa, P.1    Mendoza, L.2
  • 57
    • 78651299880 scopus 로고    scopus 로고
    • Combining network modeling and gene expression microarray analysis to explore the dynamics of Th1 and Th2 cell regulation
    • M. Pedicini, F. Barrenäs, T. Clancy et al., "Combining network modeling and gene expression microarray analysis to explore the dynamics of Th1 and Th2 cell regulation", PLoS Computational Biology, vol. 6, no. 12, Article IDe1001032, 8 pages, 2010.
    • (2010) PLoS Computational Biology , vol.6 , Issue.12 , pp. 8
    • Pedicini, M.1    Barrenäs, F.2    Clancy, T.3
  • 58
    • 78049424847 scopus 로고    scopus 로고
    • Diversity and plasticity of Thcell types predicted fromregulatory network modelling
    • A. Naldi, J. Carneiro, C. Chaouiya, and D. Thieffry, "Diversity and plasticity of Thcell types predicted fromregulatory network modelling", PLoS Computational Biology, vol. 6, no. 9, Article ID e1000912, 2010.
    • (2010) PLoS Computational Biology , vol.6 , Issue.9
    • Naldi, A.1    Carneiro, J.2    Chaouiya, C.3    Thieffry, D.4
  • 59
    • 85099683746 scopus 로고    scopus 로고
    • The onset of type 2 diabetes: Proposal for a multi-scale model
    • F. Castiglione, P. Tieri, A. de Graaf et al., "The onset of type 2 diabetes: proposal for a multi-scale model", JMIR Research Protocols, vol. 2, no. 2, p. e44, 2013.
    • (2013) JMIR Research Protocols , vol.2 , Issue.2 , pp. e44
    • Castiglione, F.1    Tieri, P.2    De Graaf, A.3
  • 61
    • 53449101249 scopus 로고    scopus 로고
    • Cell transmembrane receptors determine tissue pattern stability
    • T. Beyer and M. Meyer-Hermann, "Cell transmembrane receptors determine tissue pattern stability", Physical Review Letters, vol. 101, no. 14, Article ID 148102, 2008.
    • (2008) Physical Review Letters , vol.101 , Issue.14
    • Beyer, T.1    Meyer-Hermann, M.2
  • 62
    • 79551565619 scopus 로고    scopus 로고
    • A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt
    • P. Buske, J. Galle, N. Barker, G. Aust, H. Clevers, and M. Loeffler, "A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt", PLoS Computational Biology, vol. 7, no. 1, Article ID e1001045, 2011.
    • (2011) PLoS Computational Biology , vol.7 , Issue.1
    • Buske, P.1    Galle, J.2    Barker, N.3    Aust, G.4    Clevers, H.5    Loeffler, M.6
  • 63
    • 79955030886 scopus 로고    scopus 로고
    • Multiscale modelling of vascular tumour growth in 3D: The roles of domain size and boundary conditions
    • H. Perfahl, H. M. Byrne, T. Chen et al., "Multiscale modelling of vascular tumour growth in 3D: The roles of domain size and boundary conditions", PLoS ONE, vol. 6, no. 4, Article ID e14790, 2011.
    • (2011) PLoS ONE , vol.6 , Issue.4
    • Perfahl, H.1    Byrne, H.M.2    Chen, T.3
  • 64
    • 84902649698 scopus 로고    scopus 로고
    • The multi-scale immune response to pathogens: M. Tuberculosis as an example
    • D. Flower and J. Timmis, Eds., Springer, Berlin, Germany
    • D. Kirschner, "The multi-scale immune response to pathogens: M. tuberculosis as an example", in In Silico Immunology, D. Flower and J. Timmis, Eds., pp. 289-311, Springer, Berlin, Germany, 2007.
    • (2007) Silico Immunology , pp. 289-311
    • Kirschner, D.1
  • 66
    • 33746516694 scopus 로고    scopus 로고
    • A hybrid deterministic-stochastic algorithm for modeling cell signaling dynamics in spatially inhomogeneous environments and under the influence of external fields
    • D. C. Wylie, Y. Hori, A. R. Dinner, and A. K. Chakraborty, "A hybrid deterministic-stochastic algorithm for modeling cell signaling dynamics in spatially inhomogeneous environments and under the influence of external fields", Journal of Physical Chemistry B, vol. 110, no. 25, pp. 12749-12765, 2006.
    • (2006) Journal of Physical Chemistry B , vol.110 , Issue.25 , pp. 12749-12765
    • Wylie, D.C.1    Hori, Y.2    Dinner, A.R.3    Chakraborty, A.K.4
  • 69
    • 0037342537 scopus 로고    scopus 로고
    • The systems biology markup language (SBML): A medium for representation and exchange of biochemical network models
    • M. Hucka, A. Finney, H. M. Sauro et al., "The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models", Bioinformatics, vol. 19, no. 4, pp. 524-531, 2003.
    • (2003) Bioinformatics , vol.19 , Issue.4 , pp. 524-531
    • Hucka, M.1    Finney, A.2    Sauro, H.M.3
  • 70
  • 71
    • 0347511691 scopus 로고    scopus 로고
    • Next Generation Simulation Tools: The Systems Biology Workbench and BioSPICE Integration
    • H. M. Sauro, M. Hucka, A. Finney et al., "Next Generation Simulation Tools: The Systems Biology Workbench and BioSPICE Integration", OMICS A Journal of Integrative Biology, vol. 7, no. 4, pp. 355-372, 2003.
    • (2003) OMICS a Journal of Integrative Biology , vol.7 , Issue.4 , pp. 355-372
    • Sauro, H.M.1    Hucka, M.2    Finney, A.3
  • 74
    • 79953069544 scopus 로고    scopus 로고
    • A complex automata approach for in-stent restenosis: Two-dimensional multiscale modelling and simulations
    • A. Caiazzo, D. Evans, J. Falcone et al., "A complex automata approach for in-stent restenosis: two-dimensional multiscale modelling and simulations", Journal of Computational Science, vol. 2, no. 1, pp. 9-17, 2011.
    • (2011) Journal of Computational Science , vol.2 , Issue.1 , pp. 9-17
    • Caiazzo, A.1    Evans, D.2    Falcone, J.3
  • 75
    • 84856965068 scopus 로고    scopus 로고
    • Multi-scale simulations of the dynamics of in-stent restenosis: Impact of stent deployment and design
    • H. Tahir, A. G. Hoekstra, E. Lorenz et al., "Multi-scale simulations of the dynamics of in-stent restenosis: impact of stent deployment and design", Interface Focus, vol. 1, no. 3, pp. 365-373, 2011.
    • (2011) Interface Focus , vol.1 , Issue.3 , pp. 365-373
    • Tahir, H.1    Hoekstra, A.G.2    Lorenz, E.3
  • 76
    • 56249123996 scopus 로고    scopus 로고
    • Characterizing emergent properties of immunological systems with multi-cellular rule-based computational modeling
    • A. K. Chavali, E. P. Gianchandani, K. S. Tung, M. B. Lawrence, S. M. Peirce, and J. A. Papin, "Characterizing emergent properties of immunological systems with multi-cellular rule-based computational modeling", Trends in Immunology, vol. 29, no. 12, pp. 589-599, 2008.
    • (2008) Trends in Immunology , vol.29 , Issue.12 , pp. 589-599
    • Chavali, A.K.1    Gianchandani, E.P.2    Tung, K.S.3    Lawrence, M.B.4    Peirce, S.M.5    Papin, J.A.6


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