Vitamin A and retinoic acid in T cell-related immunity

American Journal of Clinical Nutrition

Volumn 96, Issue 5, 2012, Pages

  Ross, A Catharine ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID; RETINOL;

ANTIBODY RESPONSE; CELL DIFFERENTIATION; CELL HOMING; HUMAN; IMMUNITY; IMMUNOMODULATION; INFLAMMATION; INTESTINE; LYMPHOCYTE MIGRATION; NONHUMAN; REGULATORY T LYMPHOCYTE; REVIEW; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; HUMANS; IMMUNITY, MUCOSAL; INTESTINES; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TRETINOIN; VITAMIN A;

EID: 84867801979     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.112.034637     Document Type: Review

References (73)

1. Green HN, Mellanby E. Vitamin A as an anti-infective agent. BMJ 1928;2:691-6.
2. Green HN, Mellanby E. Carotene and vitamin A: the anti-infective action of carotene. Br J Exp Pathol 1930;11:81-9.
3. Mellanby E. Nutrition and disease: The interaction of clinical and experimental work. Edinburgh, United Kingdom: Oliver and Boyd, 1934.
4. Beaton GH, Martorell R, Aronson KA, Edmonston B. McCabe, G, Ross, AC, Harvey, B. Vitamin A supplementation and child morbidity and mortality in developing countries. Food Nutr Bull 1994;15(4):282-9. (Pubitemid 26465968)
5. Semba RD. Vitamin A and immunity to viral, bacterial and protozoan infections. Proc Nutr Soc 1999;58:719-27.
6. Semba RD. The vitamin A and mortality paradigm: past, present, and future. Scand J Nutr 2001;45:46-50. (Pubitemid 32634234)
7. Bhutta ZA, Ahmed T, Black R, Cousens S, Dewey K, Giugliani E, Haider BA, Kirkwood B, Morris SS, Sachdev HP, et al Maternal and Child Undernutrition Study Group. What works? Interventions for maternal and child undernutrition and survival. Lancet 2008;371:417-40.
8. Sommer A, Vyas KS. A global clinical view on vitamin A and carotenoids. Am J Clin Nutr 2012;96:1204S-6S.
9. Stephensen CB. Vitamin A, infection, and immune function. Annu Rev Nutr 2001;21:167-92. (Pubitemid 32695269)
10. Villamor E, Fawzi WW. Effects of vitamin A supplementation on immune responses and correlation with clinical outcomes. Clin Microbiol Rev 2005;18:446-64. (Pubitemid 40995111)
11. WHO. Progress in reducing global measles deaths: 1999-2004. Wkly Epidemiol Rec 2006;81:90-4.
12. Duriancik DM, Lackey DE, Hoag KA. Vitamin A as a regulator of antigen presenting cells. J Nutr 2010;140:1395-9.
13. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57. (Pubitemid 16136806)
14. Mosmann TR, Coffman RL. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;17:145-73. (Pubitemid 19138011)
15. Cantorna MT, Nashold FE, Hayes CE. Vitamin A deficiency results in a priming environment conducive for Th1 cell development. Eur J Immunol 1995;25:1673-9.
16. Smith SM, Levy NL, Hayes CE. Impaired immunity in vitamin A deficient mice. J Nutr 1987;117:857-65. (Pubitemid 17093565)
17. Hoag KA, Nashold FE, Goverman J, Hayes CE. Retinoic acid enhances the T helper 2 cell development that is essential for robust antibody responses through its action on antigen-presenting cells. J Nutr 2002;132:3736-9. (Pubitemid 35435055)
18. Stephensen CB, Rasooly R, Jiang X, Ceddia MA, Weaver CT, Chandraratna RA, Bucy RP. Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway. J Immunol 2002;168:4495-503. (Pubitemid 34441352)
19. Iwata M, Eshima Y, Kagechika H. Retinoic acids exert direct effects on T cells to suppress T(h)1 development and enhance T(h)2 development via retinoic acid receptors. Int Immunol 2003;15:1017-25. (Pubitemid 36987299)
20. Stephensen CB, Jiang X, Freytag T. Vitamin A deficiency increases the in vivo development of IL-10-positive Th2 cells and decreases development of Th1 cells in mice. J Nutr 2004;134:2660-6. (Pubitemid 39315269)
21. Ross AC, Chen QYM. Augmentation of antibody responses by retinoic acid and costimulatory molecules. Semin Immunol 2009;21:42-50.
22. Ma Y, Chen Q, Ross AC. Retinoic acid and polyriboinosinic: polyribocytidylic acid stimulate robust anti-tetanus antibody production while differentially regulating type 1/type 2 cytokines and lymphocyte populations. J Immunol 2005;174:7961-9. (Pubitemid 40806306)
23. Djuretic IM, Levanon D, Negreanu V, Groner Y, Rao A, Ansel KM. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol 2007;8:145-53. (Pubitemid 46152645)
24. Wilson CB, Rowell E, Sekimata M. Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol 2009;9:91-105.
25. Van YH, Lee WH, Ortiz S, Lee MH, Qin HJ, Liu CP. All-trans retinoic acid inhibits type 1 diabetes by T regulatory (Treg)-dependent suppression of interferon-gamma-producing T-cells without affecting Th17 cells. Diabetes 2009;58:24-5.
26. Locksley RM. Nine lives: plasticity among T helper cell subsets. J Exp Med 2009;206:1643-6.
27. Weaver CT, Hatton RD. Interplay between the Th17 and Treg cell lineages: a (co)evolutionary perspective. Nat Rev Immunol 2009;9:883-9.
28. Ziegler SF, Buckner JH. FOXP3 and the regulation of Treg/Th17 differentiation. Microbes Infect 2009;11:594-8.
29. Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol 2010;40:1830-5.
30. Eberl G, Littman DR. The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches. Immunol Rev 2003;195:81-90. (Pubitemid 37153455)
31. Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 2010;10:490-500.
32. Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H. Reciprocal TH17 and regulatory T cell differentiation induced by retinoic acid. Science 2007;317:256-60. (Pubitemid 47076203)
33. Benson MJ, Pino-Lagos K, Rosemblatt N, Noelle RJ. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation and homing in the face of high levels of co-stimulation. J Exp Med 2007;204:1765-74. (Pubitemid 47236315)
34. Mucida D, Park Y, Cheroutre H. From the diet to the nucleus: vitamin A and TGF-β join efforts at the mucosal interface of the intestine. Semin Immunol 2009;21:14-21.
35. Xiao S, Jin H, Korn T, Liu SM, Oukka M, Lim B, Kuchroo VK. Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL23 receptor expression. J Immunol 2008;181:2277-84.
36. Takaki H, Ichiyama K, Koga K, Chinen T, Takaesu G, Sugiyama Y, Kato S, Yoshimura A, Kobayashi T. STAT6 inhibits TGF-β1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor. J Biol Chem 2008;283:14955-62.
37. Zhou L, Chong MMW, Littman DR. Plasticity of CD4+ T cell lineage differentiation. Immunity 2009;30:646-55.
38. Koenen HJ, Smeets RL, Vink PM, van Rijsses E, Boots AM, Joosten I. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood 2008;112:2340-52.
39. Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh T-Y, Watford WT, et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 2009;30:155-67.
40. Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA. Selective miRNA disruption of T reg cells leads to uncontrolled autoimmunity. J Exp Med 2008;205:1983-91.
41. Ziegler TR, Evans ME, Fernández-Est'variz C, Jones DP. Trophic and cytoprotective nutrition for intestinal adaptation, mucosal repair, and barrier function. Annu Rev Nutr 2003;23:229-61. (Pubitemid 37059723)
42. Gray T, Koo JS, Nettesheim P. Regulation of mucous differentiation and mucin gene expression in the tracheobronchial epithelium. Toxicology 2001;60:35-46. (Pubitemid 32200462)
43. Gangopadhyay NN, Moldoveanu Z, Stephensen CB. Vitamin A deficiency has different effects on immunoglobulin A production and transport during influenza A infection in BALB/c mice. J Nutr 1996;126:2960-7. (Pubitemid 27023868)
44. Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song SY. Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004;21:527-38. (Pubitemid 39370508)
45. Iwata M. Retinoic acid production by intestinal dendritic cells and its role in T-cell trafficking. Semin Immunol 2009;21:8-13.
46. Menning A, Loddenkemper C, Westendorf AM, Szilagyi B, Buer J, Siewert C, Hamann A, Huehn J. Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation. Eur J Immunol 2010;40(9):2539-48.
47. Menning A, Loddenkemper C, Westendorf AM, Szilagyi B, Buer J, Siewert C, Hamann A, Huehn J. Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation. Eur J Immunol 2010;40:2539-48.
48. Kang SG, Wang C, Matsumoto S, Kim CH. High and low vitamin A therapies induce distinct FoxP3+ T-cell subsets and effectively control intestinal inflammation. Gastroenterology 2009;137:1391-402.
49. Coombes JL, Siddiqui KRR, Arancibia-Carcamo CV, Hall J, Sun CM, Belkaid Y, Powrie F. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β- and retinoic acid-dependent mechanism. J Exp Med 2007;204:1757-64. (Pubitemid 47236314)
50. Blomhoff R, Blomhoff HK. Overview of retinoid metabolism and function. J Neurobiol 2006;66:606-30. (Pubitemid 43941649)
51. Eksteen B, Mora JR, Haughton EL, Henderson NC, Lee-Turner L, Villablanca EJ, Curbishley SM, Aspinall AI, von Andrian UH, Adams DH. Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells. Gastroenterology 2009;137:320-9.
52. Chang S-Y, Cha H-R, Chang J-H, Ko H-J, Yang H, Malissen B, Iwata M, Kweon M-N. Lack of retinoic acid leads to increased langerinexpressing dendritic cells in gut-associated lymphoid tissue. Gastroenterology 2010;138:1468-78.
53. DePaolo RW, Abadie V, Tang F, Fehlner-Peach H, Hall JA, Wang W, Marietta EV, Kasarda DD, Waldmann TA, Murray JA, et al. Coadjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature 2011;471:220-4.
54. Ertesva°g A, Naderi S, Blomhoff HK. Regulation of B cell proliferation and differentiation by retinoic acid. Semin Immunol 2009;21:36-41.
55. Naderi S, Blomhoff HK. Retinoic acid prevents phosphorylation of pRB in normal human B lymphocytes: regulation of cyclin E, cyclin A, and p21(Cip1). Blood 1999;94:1348-58. (Pubitemid 29380416)
56. Chen Q, Ross AC. Vitamin A and immune function: retinoic acid modulates population dynamics in antigen receptor and CD38-stimulated splenic B cells. Proc Natl Acad Sci USA 2005;102:14142-9. (Pubitemid 41429666)
57. Chen Q, Ross AC. Retinoic acid promotes mouse splenic B cell surface IgG expression and maturation stimulated by CD40 and IL-4. Cell Immunol 2007;249:37-45.
58. Pasatiempo AM, Kinoshita M, Taylor CE, Ross AC. Antibody production in vitamin A-depleted rats is impaired after immunization with bacterial polysaccharide or protein antigens. FASEB J 1990;4:2518-27.
59. Sankaranarayanan S, Ma Y, Bryson MS, Li N-Q, Ross AC. Neonatalage treatment with vitamin A delays postweaning vitamin A deficiency and increases the antibody response to T-cell dependent antigens in young adult rats fed a vitamin A-deficient diet. J Nutr 2007;137:1229-35. (Pubitemid 46701916)
60. Stephensen CB, Moldoveanu Z, Gangopadhyay NN. Vitamin A deficiency diminishes the salivary immunoglobulin A response and enhances the serum immunoglobulin G response to influenza A virus infection in BALB/c mice. J Nutr 1996;126:94-102. (Pubitemid 26030638)
61. Twining SS, Schulte DP, Wilson PM, Fish BL, Moulder JE. Vitamin A deficiency alters rat neutrophil function. J Nutr 1997;127:558-65. (Pubitemid 27163620)
62. Zhao Z, Ross AC. Retinoic acid repletion restores the number of leukocytes and their subsets and stimulates natural cytotoxicity in vitamin A-deficient rats. J Nutr 1995;125:2064-73.
63. Kuwata T, Wang I-M, Tamura T, Ponnamperuma RM, Levine R, Holmes KL, Morse HC III, DeLuca LM, Ozato K. Vitamin A deficiency in mice causes a systemic expansion of myeloid cells. Blood 2000;95:3349-56. (Pubitemid 30428463)
64. Cattoretti G, Buttner M, Shaknovich R, Kremmer E, Alobeid B, Niedobitek G. Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells. Blood 2006;107:3967-75. (Pubitemid 43726803)
65. Ma Y, Ross AC. Toll-like receptor 3 ligand and retinoic acid enhance germinal center formation and increase the tetanus toxoid vaccine response. Clin Vaccine Immunol 2009;16:1476-84.
66. Ma Y, Ross AC. The anti-tetanus immune response of neonatal mice is augmented by retinoic acid combined with polyriboinosinic:polyribocytidylic acid. Proc Natl Acad Sci USA 2005;102:13556-61. (Pubitemid 41420887)
67. Takahashi H, Kanno T, Nakayamada S, Kirahar K, Sciumé G, Muljo SA, Kuchen S, Casellas R, Wei L, Kanno Y, et al. TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nat Immunol 2012;13:587-95.
68. Takeuchi H, Yokoto A, Ohoka Y, Iwata M. Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor b. PLoS ONE 2011;6:e16089.
69. Expanded Programme on Immunization. EPI Global Advisory Group Meeting E-G. Programmes for the control of vitamin A deficiency: the role of the EPI in new initiatives for the 1990's. World Health Organization 1988;October:1-23.
70. Molenaar R, Knippenberg M, Goverse G, Olivier BJ, deVos AF, O'Toole T, Mebius RE. Expression of retinaldehyde dehydrogenase enzymes in mucosal dendritic cells and gut-draining lymph node stromal cells is controlled by dietary vitamin A. J Immunol 2011;186:1934-42.
71. Wang XD, Russell RM, Marini RP, Tang G, Dolnikowski GG, Fox JG, Krinsky NI. Intestinal perfusion of beta-carotene in the ferret raises retinoic acid level in portal blood. Biochim Biophys Acta 1993;1167:159-64. (Pubitemid 23104910)
72. Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, Wiita P, Bok D, Sun H. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science 2007;315:820-5.
73. Skrede B, Olafsdottir AE, Blomhoff R, Norum KR. Retinol and retinyl esters in rabbit bone marrow and blood leukocytes. Scand J Clin Lab Invest 1993;53:515-9. (Pubitemid 23244227)