메뉴 건너뛰기




Volumn 467, Issue C, 2009, Pages 79-109

Modeling and Simulation of the Immune System as a Self-Regulating Network

Author keywords

[No Author keywords available]

Indexed keywords

AUTOREGULATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL POPULATION; COMPUTER SIMULATION; IMMUNE SYSTEM; IMMUNOREGULATION; NEGATIVE FEEDBACK; PRIORITY JOURNAL; REVIEW; STOCHASTIC MODEL;

EID: 71549163142     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(09)67004-X     Document Type: Review
Times cited : (39)

References (60)
  • 1
    • 0037459917 scopus 로고    scopus 로고
    • Models of CD8+ responses: 1. What is the antigen-independent proliferation program
    • Antia R., Bergstrom C.T., Pilyugin S.S., Kaech S.M., and Ahmed R. Models of CD8+ responses: 1. What is the antigen-independent proliferation program. J. Theor. Biol. 221 4 (2003) 585-598
    • (2003) J. Theor. Biol. , vol.221 , Issue.4 , pp. 585-598
    • Antia, R.1    Bergstrom, C.T.2    Pilyugin, S.S.3    Kaech, S.M.4    Ahmed, R.5
  • 3
    • 67049167214 scopus 로고    scopus 로고
    • Quantifying the development of the peripheral naive CD4+ T-cell pool in humans
    • Bains I., Antia R., Callard R., and Yates A.J. Quantifying the development of the peripheral naive CD4+ T-cell pool in humans. Blood 113 22 (2009) 5480-5487
    • (2009) Blood , vol.113 , Issue.22 , pp. 5480-5487
    • Bains, I.1    Antia, R.2    Callard, R.3    Yates, A.J.4
  • 6
    • 33744534672 scopus 로고    scopus 로고
    • Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses
    • Burroughs N.J., de Oliveira B.M.P.M., and Pinto A.A. Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses. J. Theor. Biol. 241 (2006) 134-141
    • (2006) J. Theor. Biol. , vol.241 , pp. 134-141
    • Burroughs, N.J.1    de Oliveira, B.M.P.M.2    Pinto, A.A.3
  • 8
    • 1842671656 scopus 로고    scopus 로고
    • The damage-response framework of microbial pathogenesis
    • Casadevall A., and Pirofski L.A. The damage-response framework of microbial pathogenesis. Nat. Rev. Microbiol. 1 (2003) 17-24
    • (2003) Nat. Rev. Microbiol. , vol.1 , pp. 17-24
    • Casadevall, A.1    Pirofski, L.A.2
  • 9
    • 33747821468 scopus 로고    scopus 로고
    • A reappraisal of humoral immunity based on mechanisms of antibody-mediated protection against intracellular pathogens
    • Casadevall A., and Pirofski L.A. A reappraisal of humoral immunity based on mechanisms of antibody-mediated protection against intracellular pathogens. Adv. Immunol. 91 (2006) 1-44
    • (2006) Adv. Immunol. , vol.91 , pp. 1-44
    • Casadevall, A.1    Pirofski, L.A.2
  • 10
    • 23744434889 scopus 로고    scopus 로고
    • Agent-based modeling of the context dependency in T cell recognition
    • Casal A., Sumen C., Reddy T.E., Alber M.S., and Lee P.P. Agent-based modeling of the context dependency in T cell recognition. J. Theor. Biol. 236 4 (2005) 376-391
    • (2005) J. Theor. Biol. , vol.236 , Issue.4 , pp. 376-391
    • Casal, A.1    Sumen, C.2    Reddy, T.E.3    Alber, M.S.4    Lee, P.P.5
  • 11
    • 4444329364 scopus 로고    scopus 로고
    • Visualizing the first 50 hr of the primary immune response to a soluble antigen
    • Catron D.M., Itano A.A., Pape K.A., Mueller D.L., and Jenkins M.K. Visualizing the first 50 hr of the primary immune response to a soluble antigen. Immunity 21 3 (2004) 341-347
    • (2004) Immunity , vol.21 , Issue.3 , pp. 341-347
    • Catron, D.M.1    Itano, A.A.2    Pape, K.A.3    Mueller, D.L.4    Jenkins, M.K.5
  • 12
    • 0026556477 scopus 로고
    • A computer model of cellular interactions in the immune system
    • Celada F., and Seiden P.E. A computer model of cellular interactions in the immune system. Immunol. Today 13 2 (1992) 56-62
    • (1992) Immunol. Today , vol.13 , Issue.2 , pp. 56-62
    • Celada, F.1    Seiden, P.E.2
  • 13
    • 26044442893 scopus 로고    scopus 로고
    • A mathematical model of hematopoiesis-II. Cyclical neutropenia
    • Colijn C., and Mackey M.C. A mathematical model of hematopoiesis-II. Cyclical neutropenia. J. Theor. Biol. 237 2 (2005) 133-146
    • (2005) J. Theor. Biol. , vol.237 , Issue.2 , pp. 133-146
    • Colijn, C.1    Mackey, M.C.2
  • 14
    • 0025849021 scopus 로고
    • Size and connectivity as emergent properties of a developing immune network
    • De Boer R.J., and Perelson A.S. Size and connectivity as emergent properties of a developing immune network. J. Theor. Biol. 149 3 (1990) 381-424
    • (1990) J. Theor. Biol. , vol.149 , Issue.3 , pp. 381-424
    • De Boer, R.J.1    Perelson, A.S.2
  • 16
    • 24744472075 scopus 로고    scopus 로고
    • A validated mathematical model of cell-mediated immune response to tumor growth
    • de Pillis L.G., Radunskaya A.E., and Wiseman C.L. A validated mathematical model of cell-mediated immune response to tumor growth. Cancer Res. 65 17 (2005) 7950-7958
    • (2005) Cancer Res. , vol.65 , Issue.17 , pp. 7950-7958
    • de Pillis, L.G.1    Radunskaya, A.E.2    Wiseman, C.L.3
  • 18
    • 66549109067 scopus 로고    scopus 로고
    • Optimization of immunoglobulin substitution therapy by a stochastic immune response model
    • Figge M.T. Optimization of immunoglobulin substitution therapy by a stochastic immune response model. PLoS ONE 4 5 (2009) e5685
    • (2009) PLoS ONE , vol.4 , Issue.5
    • Figge, M.T.1
  • 20
    • 38049136890 scopus 로고    scopus 로고
    • The Basic Immune Simulator: An agent-based model to study the interactions between innate and adaptive immunity
    • Folcik V.A., An G.C., and Orosz C.G. The Basic Immune Simulator: An agent-based model to study the interactions between innate and adaptive immunity. Theor. Biol. Med. Model. 4 (2007) 39
    • (2007) Theor. Biol. Med. Model. , vol.4 , pp. 39
    • Folcik, V.A.1    An, G.C.2    Orosz, C.G.3
  • 22
    • 48449104143 scopus 로고    scopus 로고
    • A population dynamics analysis of the interaction between adaptive regulatory T cells and antigen presenting cells
    • Fouchet D., and Regoes R. A population dynamics analysis of the interaction between adaptive regulatory T cells and antigen presenting cells. PLoS ONE 3 5 (2008) e2306
    • (2008) PLoS ONE , vol.3 , Issue.5
    • Fouchet, D.1    Regoes, R.2
  • 24
    • 33846466719 scopus 로고    scopus 로고
    • Immunology research: Challenges and opportunities in a time of budgetary constraint
    • Hackett C.J., Rotrosen D., Auchincloss H., and Fauci A.S. Immunology research: Challenges and opportunities in a time of budgetary constraint. Nat. Immunol. 8 2 (2007) 114-117
    • (2007) Nat. Immunol. , vol.8 , Issue.2 , pp. 114-117
    • Hackett, C.J.1    Rotrosen, D.2    Auchincloss, H.3    Fauci, A.S.4
  • 25
    • 0034046181 scopus 로고    scopus 로고
    • Regulation of antibody responses via antibodies, complement, and Fc receptors
    • Heyman B. Regulation of antibody responses via antibodies, complement, and Fc receptors. Annu. Rev. Immunol. 18 (2000) 709-737
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 709-737
    • Heyman, B.1
  • 26
    • 0038782572 scopus 로고    scopus 로고
    • Feedback regulation by IgG antibodies
    • Heyman B. Feedback regulation by IgG antibodies. Immunol. Lett. 88 2 (2003) 157-161
    • (2003) Immunol. Lett. , vol.88 , Issue.2 , pp. 157-161
    • Heyman, B.1
  • 27
    • 0035348175 scopus 로고    scopus 로고
    • Memory CD8+ T cell differentiation: Initial antigen encounter triggers a developmental program in naïve cells
    • Kaech S.M., and Ahmed R. Memory CD8+ T cell differentiation: Initial antigen encounter triggers a developmental program in naïve cells. Nat. Immunol. 2 5 (2001) 415-422
    • (2001) Nat. Immunol. , vol.2 , Issue.5 , pp. 415-422
    • Kaech, S.M.1    Ahmed, R.2
  • 28
    • 0031439719 scopus 로고    scopus 로고
    • Human tumor antigens recognized by T-cells
    • Kawakami Y., and Rosenberg S.A. Human tumor antigens recognized by T-cells. Immunol. Res. 16 4 (1997) 313-339
    • (1997) Immunol. Res. , vol.16 , Issue.4 , pp. 313-339
    • Kawakami, Y.1    Rosenberg, S.A.2
  • 30
    • 34047271419 scopus 로고    scopus 로고
    • Modeling regulation mechanisms of the immune system
    • Kim P.S., Lee P.P., and Levy D. Modeling regulation mechanisms of the immune system. J. Theor. Biol. 246 (2007) 33-69
    • (2007) J. Theor. Biol. , vol.246 , pp. 33-69
    • Kim, P.S.1    Lee, P.P.2    Levy, D.3
  • 31
    • 41049113495 scopus 로고    scopus 로고
    • Modeling imatinib-treated chronic myelogenous leukemia: Reducing the complexity of agent-based models
    • Kim P.S., Lee P.P., and Levy D. Modeling imatinib-treated chronic myelogenous leukemia: Reducing the complexity of agent-based models. Bull. Math. Biol. 70 3 (2008) 728-744
    • (2008) Bull. Math. Biol. , vol.70 , Issue.3 , pp. 728-744
    • Kim, P.S.1    Lee, P.P.2    Levy, D.3
  • 33
    • 0347572864 scopus 로고    scopus 로고
    • Tolerance and immunity in a mathematical model of T-cell mediated suppression
    • León K., Lage A., and Carneiro J. Tolerance and immunity in a mathematical model of T-cell mediated suppression. J. Theor. Biol. 225 (2003) 107-126
    • (2003) J. Theor. Biol. , vol.225 , pp. 107-126
    • León, K.1    Lage, A.2    Carneiro, J.3
  • 34
    • 17044454394 scopus 로고    scopus 로고
    • Inverse correlation between the incidences of autoimmune disease and infection predicted by a model of T cell mediated tolerance
    • León K., Faro J., Lage A., and Carneiro J. Inverse correlation between the incidences of autoimmune disease and infection predicted by a model of T cell mediated tolerance. J. Autoimmun. 22 (2004) 31-42
    • (2004) J. Autoimmun. , vol.22 , pp. 31-42
    • León, K.1    Faro, J.2    Lage, A.3    Carneiro, J.4
  • 35
    • 34249024527 scopus 로고    scopus 로고
    • How regulatory CD25+CD4+ T cells impinge on tumor immunobiology? On the existence of two alternative dynamical classes of tumors
    • León K., Lage A., and Carneiro J. How regulatory CD25+CD4+ T cells impinge on tumor immunobiology? On the existence of two alternative dynamical classes of tumors. J. Theor. Biol. 247 (2007) 122-137
    • (2007) J. Theor. Biol. , vol.247 , pp. 122-137
    • León, K.1    Lage, A.2    Carneiro, J.3
  • 36
    • 38349154060 scopus 로고    scopus 로고
    • How regulatory CD25+CD4+ T cells impinge on tumor immunobiology: The differential response of tumors to therapies
    • León K., Lage A., and Carneiro J. How regulatory CD25+CD4+ T cells impinge on tumor immunobiology: The differential response of tumors to therapies. J. Immunol. 179 9 (2007) 5659-5668
    • (2007) J. Immunol. , vol.179 , Issue.9 , pp. 5659-5668
    • León, K.1    Lage, A.2    Carneiro, J.3
  • 37
    • 0032171644 scopus 로고    scopus 로고
    • A very high level of crossreactivity is an essential feature of the T-cell receptor
    • Mason D. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today 19 9 (1998) 395-404
    • (1998) Immunol. Today , vol.19 , Issue.9 , pp. 395-404
    • Mason, D.1
  • 38
    • 33947191941 scopus 로고    scopus 로고
    • Cellular automata-based modeling program: Synthetic immune system
    • Mata J., and Cohn M. Cellular automata-based modeling program: Synthetic immune system. Immunol. Rev. 216 (2007) 198-212
    • (2007) Immunol. Rev. , vol.216 , pp. 198-212
    • Mata, J.1    Cohn, M.2
  • 39
    • 56349161598 scopus 로고    scopus 로고
    • B-cell tolerance checkpoints in health and autoimmunity
    • Meffre E., and Wardemann H. B-cell tolerance checkpoints in health and autoimmunity. Curr. Opin. Immunol. 20 6 (2008) 632-638
    • (2008) Curr. Opin. Immunol. , vol.20 , Issue.6 , pp. 632-638
    • Meffre, E.1    Wardemann, H.2
  • 40
    • 0034671979 scopus 로고    scopus 로고
    • Early programming of T cell populations responding to bacterial infection
    • Mercado R., Vijh S., Allen S.E., Kerksiek K., Pilip I.M., and Pamer E.G. Early programming of T cell populations responding to bacterial infection. J. Immunol. 165 12 (2000) 6833-6839
    • (2000) J. Immunol. , vol.165 , Issue.12 , pp. 6833-6839
    • Mercado, R.1    Vijh, S.2    Allen, S.E.3    Kerksiek, K.4    Pilip, I.M.5    Pamer, E.G.6
  • 41
    • 0019797316 scopus 로고
    • A model of the role of natural killer cells in immune surveillance-I
    • Merrill S.J. A model of the role of natural killer cells in immune surveillance-I. J. Math. Biol. 12 (1981) 363-373
    • (1981) J. Math. Biol. , vol.12 , pp. 363-373
    • Merrill, S.J.1
  • 42
    • 0033152972 scopus 로고    scopus 로고
    • A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia
    • Molldrem J.J., Lee P.P., Wang C., Champlin R.E., and Davis M.M. A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia. Cancer Res. 59 11 (1999) 2675-2681
    • (1999) Cancer Res. , vol.59 , Issue.11 , pp. 2675-2681
    • Molldrem, J.J.1    Lee, P.P.2    Wang, C.3    Champlin, R.E.4    Davis, M.M.5
  • 43
    • 1642344491 scopus 로고    scopus 로고
    • A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction
    • Moore H., and Li N.K. A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction. J. Theor. Biol. 225 4 (2004) 513-523
    • (2004) J. Theor. Biol. , vol.225 , Issue.4 , pp. 513-523
    • Moore, H.1    Li, N.K.2
  • 45
    • 41149148789 scopus 로고    scopus 로고
    • The impact of T-cell immunity on ovarian cancer outcomes
    • Nelson B.H. The impact of T-cell immunity on ovarian cancer outcomes. Immunol. Rev. 222 (2008) 101-116
    • (2008) Immunol. Rev. , vol.222 , pp. 101-116
    • Nelson, B.H.1
  • 47
    • 34047218649 scopus 로고    scopus 로고
    • A mathematical model for neutrophil gradient sensing and polarization
    • Onsum M., and Rao C.V. A mathematical model for neutrophil gradient sensing and polarization. PLoS Comput. Biol. 3 3 (2007) e36
    • (2007) PLoS Comput. Biol. , vol.3 , Issue.3
    • Onsum, M.1    Rao, C.V.2
  • 48
    • 0033545982 scopus 로고    scopus 로고
    • Inducing autoimmune disease to treat cancer
    • Pardoll D.M. Inducing autoimmune disease to treat cancer. Proc. Natl. Acad. Sci. USA 96 10 (1999) 5340-5342
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , Issue.10 , pp. 5340-5342
    • Pardoll, D.M.1
  • 49
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky K. Clonal selection and learning in the antibody system. Nature 381 6585 (1996) 751-758
    • (1996) Nature , vol.381 , Issue.6585 , pp. 751-758
    • Rajewsky, K.1
  • 50
    • 0035902080 scopus 로고    scopus 로고
    • Progress in human tumour immunology and immunotherapy
    • Rosenberg S.A. Progress in human tumour immunology and immunotherapy. Nature 411 6835 (2001) 380-384
    • (2001) Nature , vol.411 , Issue.6835 , pp. 380-384
    • Rosenberg, S.A.1
  • 51
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155 3 (1995) 1151-1164
    • (1995) J. Immunol. , vol.155 , Issue.3 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 52
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S., Yamaguchi T., Nomura T., and Ono M. Regulatory T cells and immune tolerance. Cell 133 5 (2008) 775-787
    • (2008) Cell , vol.133 , Issue.5 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 53
    • 33748062992 scopus 로고    scopus 로고
    • High epitope expression levels increase competition between T cells
    • Scherer A., Salathé M., and Bonhoeffer S. High epitope expression levels increase competition between T cells. PLoS Comput. Biol. 2 8 (2006) e109
    • (2006) PLoS Comput. Biol. , vol.2 , Issue.8
    • Scherer, A.1    Salathé, M.2    Bonhoeffer, S.3
  • 54
    • 0026459891 scopus 로고
    • A model for simulating cognate recognition and response in the immune system
    • Seiden P.E., and Celada F. A model for simulating cognate recognition and response in the immune system. J. Theor. Biol. 158 3 (1992) 329-357
    • (1992) J. Theor. Biol. , vol.158 , Issue.3 , pp. 329-357
    • Seiden, P.E.1    Celada, F.2
  • 55
    • 30344455329 scopus 로고    scopus 로고
    • B cell development in aging mice: Lessons from mathematical modeling
    • Shahaf G., Johnson K., and Mehr R. B cell development in aging mice: Lessons from mathematical modeling. Int. Immunol. 18 (2005) 31-39
    • (2005) Int. Immunol. , vol.18 , pp. 31-39
    • Shahaf, G.1    Johnson, K.2    Mehr, R.3
  • 58
    • 0025296465 scopus 로고
    • Dynamics of a class of immune networks: Global stability of idiotype interactions
    • Varela F.J., and Stewart J. Dynamics of a class of immune networks: Global stability of idiotype interactions. J. Theor. Biol. 144 (1990) 93-101
    • (1990) J. Theor. Biol. , vol.144 , pp. 93-101
    • Varela, F.J.1    Stewart, J.2
  • 59
    • 0025077418 scopus 로고
    • Localized memories in idiotypic networks
    • Weisbuch G., DeBoer R.J., and Perelson A.S. Localized memories in idiotypic networks. J. Theor. Biol. 146 4 (1990) 483-499
    • (1990) J. Theor. Biol. , vol.146 , Issue.4 , pp. 483-499
    • Weisbuch, G.1    DeBoer, R.J.2    Perelson, A.S.3
  • 60
    • 24144457002 scopus 로고    scopus 로고
    • Effect of the CTL proliferation program on virus dynamics
    • Wodarz D., and Thomsen A.R. Effect of the CTL proliferation program on virus dynamics. Int. Immunol. 17 9 (2005) 1269-1276
    • (2005) Int. Immunol. , vol.17 , Issue.9 , pp. 1269-1276
    • Wodarz, D.1    Thomsen, A.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.