Reprogramming of the immune system during zinc deficiency

Annual Review of Nutrition

Volumn 24, Issue , 2004, Pages 277-298

  Fraker, Pamela J ^a   King, Louis E ^a  

^a Michigan State University   (United States)

Author keywords

Apoptosis; Glucocorticoids; Hematopoiesis; Lymphopoiesis; Myelopoiesis

Indexed keywords

CARRIER PROTEIN; CYTOKINE; GLUCOCORTICOID; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADAPTATION; APOPTOSIS; B LYMPHOCYTE; CELL DEATH; CELLULAR IMMUNITY; CELLULAR IMMUNODEFICIENCY; CLINICAL FEATURE; DIET SUPPLEMENTATION; GENE EXPRESSION; HUMAN; HUMORAL IMMUNE DEFICIENCY; HUMORAL IMMUNITY; IMMUNITY; IMMUNOTHERAPY; INFECTION SENSITIVITY; LYMPHOCYTOPENIA; LYMPHOPOIESIS; MYELOPOIESIS; NONHUMAN; NUTRITION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STRESS; T LYMPHOCYTE; THYMUS ATROPHY; ZINC DEFICIENCY;

ANTIBODY FORMATION; APOPTOSIS; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; IMMUNE SYSTEM; IMMUNITY, CELLULAR; MYELOPOIESIS; ZINC;

ANIMALIA;

EID: 3142705632     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nutr.24.012003.132454     Document Type: Review

References (67)

1. Allen JI, Perri RT, McClain CJ, Kay NE. 1983. Alterations in human natural killer cell activity and monocyte cytotoxicity induced by zinc deficiency. J. Lab. Clin. Med. 102:577-89
2. Ames B. 2001. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat. Res. 475:7-20
3. Bao B, Prasad AS, Beck FW, Godmere M. 2003. Zinc modulates mRNA levels of IL-2 and IFN-{gamma} positively in HUT-78 and D1.1 cells and negatively mRNA levels of TNF-{alpha}, IL-1 {beta}, and IL-8 in HL-60 cells. Am. J. Physiol. Endocrinol. Metab. 10:1152-59
4. Baum M, Campa A, Lai S, Lai H, Page J. 2003. Zinc status in human immunodeficiency virus type 1 infection and illicit drug use. Clin. Infect. Dis. 37:117-23
5. Baum M, Shor-Posner G, Compa A. 2000. Zinc status in human immunodeficiency virus infection. J. Nutr. 130:1421-23S
6. Beck MA. 1997. Increased virulence of coxsackie virus B3 in mice due to vitamin E or selenium deficiency. J. Nutr. 127:966-70S
7. Beck MA, Levander OA, Handy J. 2003. Selenium deficiency and viral infection. J. Nutr. 133:1463-67S
8. Bilbo S, Dhabhar F, Viswanathan K, Saul A, Yellon S, Nelson R. 2002. Short day lengths augment stress-induced leukocyte trafficking and stress induced enhancement of skin immune function. Proc. Natl. Acad. Sci. USA 99:4067-72
9. Black R. 2000. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries. Am. J. Clin. Nutr. 72:1516-22
10. Caldwell G, Kojima H, Lukasher D, Armstrong J, Farber M, et al. 2001. Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions. J. Immunol. 167:6140-49
11. Caulfield L, Zavaleta N, Figucio A. 1999. Adding zinc to prenatal iron and folate supplements improves maternal and neonatal zinc status in a Peruvian population. Am. J. Clin. Nutr. 69:1257-63
12. Cohen J, Duke R. 1992. Apoptosis and programmed cell death in immunity. Annu. Rev. Immunol. 10:267-304
13. Cook-Mills J, Fraker PJ. 1993. Functional capacity of residual lymphocytes from zinc deficient adult mice. Br. J. Nutr. 69:835-48
14. Cousins RJ, Blanchard RK, Moore JB, Cui L, Green CL, et al. 2003. Regulation of zinc metabolism and genomic outcomes. J. Nutr. 133:1521-26S
15. DePasquale-Jardieu P, Fraker PJ. 1979. The role of corticosterone in the loss in immune function in the zinc-deficient A/J mouse. J. Nutr. 109:1847-55
16. DePasquale-Jardieu P, Fraker PJ. 1980. Further characterization of the role of corticosterone in the loss of humoral immunity in zinc-deficient A/J mice as determined by adrenalectomy. J. Immunol. 124:2650-55
17. Dutta S, Procaccino F, Aamodt R. 1999. Zinc metabolism in patients with exocrine pancreatic insufficiency. J. Am. Coll. Nutr. 17:556-63
18. Endre L, Katona Z, Gyurkovits K. 1975. Zinc deficiency and cellular immune deficiencies in Acrodermatitis enteropathica. Lancet 1:1196-2001
19. Fernandes G, Nair N, Onoe K, Tanaka T, Floyd R, Good R. 1979. Impairment of cell mediated immunity function in dietary zinc deficiency in mice. Proc. Natl. Acad. Sci. USA 76:457-61
20. Finamore A, Roselli M, Meredino N, Nobili F, Vignolini F, Mengheri E. 2003. Zinc deficiency suppresses the development of oral tolerance in rats. J. Nutr. 133:191-98
21. Fong L, Li J, Farker J, Magee P. 1996. Cell proliferation and esophageal carcinogenesis in the zinc deficient rat. Carcinogenesis 17:1841-48
22. Fraker PJ, Caruso R, Kierszenbaum F. 1982. Alteration of the immune and nutritional status of mice by synergy between zinc deficiency and infection with Trypanosoma cruzi. J. Nutr. 112:1224-29
23. Fraker PJ, DePasquale-Jardieu P, Zwickl CM, Lueke R. 1978. Regeneration of T-cell helper function in zinc-deficient adult mice. Proc. Nat. Acad. Sci. 75:5660-66
24. Fraker PJ, King L, Laakko T, Vollmer T. 2000. The dynamic link between the integrity of the immune system and zinc status. J. Nutr. 130:13995-4065
25. Fraker PJ, Osati-Ashtiani F, Wagner M, King LL. 1995. Possible roles for glucocorticoids and apoptosis in the suppression of lymphopoiesis during zinc deficiency. J. Am. Coll. Nutr. 14:11-17
26. Garvy B, King L, Telford W, Morford L, Fraker PJ. 1993. Chronic levels of corticosterone reduces the number of cycling cells of the B-lineage in murine bone marrow and induces apoptosis. Immunology 80:587-92
27. Garvy B, Telford W, King L, Fraker PJ. 1993. Glucocorticoids and irradiation induced apoptosis in normal murine bone marrow B-lineage lymphocytes as determined by flow cytometry. Immunology 79:270-77
28. Golden M, Golden B, Harland P, Jackson A. 1978. Zinc and immunocompetence in protein energy malnutrition. Lancet i:1226-28
29. Gross R, Hansel H, Schultiuk S, Shrimpton R, Matulessi P, et al. 1998. Moderate zinc and vitamin A deficiency in breast milk of mothers from East-Jaharta. Eur. J. Clin. Nutr. 52:884-90
30. Hambidge M. 2000. Human zinc deficiency. J. Nutr. 130:1344-49S
31. Hardy R, Hayakawa K. 2001. B-cell developmental pathways. Annu. Rev. Immunol. 19:495-521
32. Hengartner M. 2000. The biochemistry of apoptosis. Nature 407:770-76
33. Ho E, Ames B. 2002. Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proc. Natl. Acad. Sci. USA 17:1841-48
34. Ho E, Courtemanche C, Ames B. 2003. Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. J. Nutr. 133:2543-48
35. Keen C. 1993. Maternal dietary zinc influences DNA strand break and 8-hydroxy-2-deoxyguanosine levels in infant rhesus monkey liver. Proc. Soc. Exp. Biol. Med. 203:416-66
36. Keen C, Gershwin M. 1990. Zinc deficiency and immune function. Annu. Rev. Nutr. 10:415-31
37. King J. 2000. Specific nutrient requirements. In Nutrition and Immunology, ed. M Gershwin, J German, C Keen, T Otowa, pp. 65-74. Totowa, NJ: Humana
38. King LE, Fraker PJ. 2002. Zinc deficiency in mice alters myelopoiesis and hematopoiesis. J. Nutr. 132:3301-7
39. King LE, Fraker PJ. 2000. Variations in cell cycle status of lymphopoietic and myelopoietic cells created by zinc deficiency. J. Infect. Dis. 182:16-22
40. King LE, Fraker PJ. 1991. Flow cytometric analysis of the phenotypic distribution of splenic lymphocytes in zinc deficient adult mouse. J. Nutr. 121:1433-38
41. King LE, Osati-Ashtiani F, Fraker PJ. 2002. A distinct role for apoptosis in the loss of precursor lymphocytes during zinc deficiency. J. Nutr. 132:974-79
42. King LE, Osati-Ashtiani F, Fraker PJ. 1995. Depletion of cells of the B-lineage in the bone marrow of zinc deficient mouse. Immunology 85:69-73
43. Krebs N, Sontag M, Accuiso F, Hambidge M. 1998. Low plasma zinc concentration in young infants with cystic fibrosis. J. Pediatr. 133:761-64
44. Kuvibidila S, Yu L, Ode D, Warrier RP. 1993. The immune response in protein-energy malnutrition and single nutrient deficiencies. In Human Nutrition: A Comprehensive Treatise, ed. DM Klurfeld, 8:121-57. New York: Plenum
45. Laakko T, Fraker PJ. 2002. Interleukin 7 mediated protection of pro and pre B-cells from the adverse effects of corticosterone. Cell Immunol. 220:39-50
46. Laakko T, Fraker PJ. 2002. Rapid changes in lymphopoietic and granulopoietic compartments of the marrow caused by stress levels of corticosterone. Immunology 105:1-15
47. Lepage L, Giesbrecht J, Taylor C. 1999. Expression of T lymphocyte p56(lck), a zinc-finger signal transduction protein, is elevated by dietary zinc deficiency and diet restriction in mice. J. Nutr. 129:620-27
48. Luecke RW, Simonel CE, Fraker PJ. 1978. The effect of restricted dietary intake on the antibody-mediated response of the zinc-deficient A/J mouse. J. Nutr. 108:881-87
49. McCabe M, Jiang J, Orrenius S. 1993. Chelation of intracellular zinc triggers apoptosis in mature thymocytes. Lab. Invest. 69:101-10
50. Merino R, Ding L, Veis D, Korsmeyer S, Nunez G. 1994. Development regulation of the Bcl-2 protein and susceptibility to cell death in B-lymphocytes. EMBO J. 13:683-91
51. Moore JB, Blanchard RK, McCormack WT, Cousins RJ. 2001. cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes. J. Nutr. 131(12):3189-96
52. Murton SA, Tan ST, Prickett TC, Frampton C, Donald RA. 1998. Hormone responses to stress in patients with major burns. Br. J. Plast. Surg. 51(5):388-92
53. Offner PJ, Moore EE, Ciesla D. 2002. The adrenal response after severe trauma. Am. J. Surg. 184(6):649-53
54. Oleski J, Westphal M, Starr S, Shore S, Gordon D, et al. 1979. Corrections with zinc therapy of depressed cellular immunity in acrodermatitis enteropathica. Am. J. Dis. Child. 133:915-21
55. Ortiz R, Cortes L, Gonzalez-Marquez H, Gomez JL, Gonzalez C, Cortes E. 2001. Flow cytometric analysis of spontaneous and dexamethasone-induced apoptosis in thymocytes from severely malnourished rats. Br. J. Nutr. 86:545-48
56. Osati F, King L, Fraker PJ. 1998. Variance in the resistance of murine early B-cells to a deficiency in zinc. Immunology 94:94-100
57. Osendarp S, van Raaij J, Darmstadt G, Baqui A, Fuchs G. 2001. Zinc supplementation during pregnancy and effects on growth and morbidity in low birth weight infants. Lancet 357:1080-85
58. Prasad AS. 1985. Clinical and biochemical manifestation of zinc deficiency in human subjects. J. Pharmacol. 16:344-52
59. Prasad AS, Miale A, Faud Z, Schubert A, Sandstead A. 1963. Zinc metabolism in patients with the syndrome of iron deficiencies, anemia, hypogonadisin and dwarfism. J. Clin. Med. 61:537-45
60. Rogers J, Taubeneck M, Daston G, Sulik K, Zucher R, et al. 1995. Zinc deficiency causes apoptosis but not cell cycle alterations in organogenesis-stage rat embryos: effect of varying duration of deficiency. Teratology 52:149-59
61. Rolink A, Melchers F. 2001. Hematopoietic stem cells: lymphopoiesis and the problem of commitment versus plasticity. In Stem Cell Biology, ed. D Marshak, R Gardner, D Gottlich, pp. 307-27. Cold Spring Harbor, NY: Cold Spring Harbor Lab. Press
62. Shi H, Scott M, Stevenson M, Koski K. 1998. Energy restriction and zinc deficiency impair the functions of murine T cells and antigen presenting cells during gastrointestinal nematode infection. J. Nutr. 28:20-27
63. Smith H, Latham M, Azaburke J, Butler W, Phillips L, et al. 1981. Blood plasma levels of cortisol, insulin, growth hormone and somatomedin in children with marasmus, kwashiorkor, and intermediate forms of protein-energy malnutrition. Proc. Soc. Exp. Biol. Med. 167:607-11
64. Tapazoglou E, Prasad AS, Hill G, Brewer G, Kaplan J. 1985. Decreased natural killer cell activity in patients with zinc deficiency with sickle cell disease. J. Lab. Clin. Med. 105:19-22
65. Wessely O, Deiner E, Beug H, Von Linden M. 1987. The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors. EMBO J. 16:267-80
66. Wing EG, Magee DM, Barczynski LK. 1988. Acute starvation in mice reduces number of T cells and suppresses the development of T cell mediated immunity. Immunology 63:677-82
67. Zemel-Babett S, Kawchali D, Fung E, Obene K, Stallings V. 2002. Effect of zinc supplementation on growth and body composition in children with sickle cell disease. Am. J. Clin. Nutr. 75:300-7