Synthesis and anticancer and lipophilic properties of 10-dialkylaminobutynyl derivatives of 1,8- and 2,7-diazaphenothiazines

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 31, Issue 6, 2016, Pages 1132-1138

  Morak Młodawska, Beata ^a   Pluta, Krystian ^a   Latocha, Małgorzata ^a   Jeleń, Małgorzata ^a   Kuśmierz, Dariusz ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Antiproliferative activity; BACL 2 BAX ratio; dialkylaminoalkynyl substituents; dipyridothiazines; phenothiazines

Indexed keywords

1,8 DIAZAPHENOTHIAZINE DERIVATIVE; 10 (4 MORPHOLIN 4 YL BUT 2 YNYL) 1,8 DIAZAPHENOTHIAZINE; 10 (4 MORPHOLIN 4 YL BUT 2 YNYL) 2,7 DIAZAPHENOTHIAZINE; 10 (4 PIPERIDIN 1 YL BUT 2 YNYL) 1,8 DIAZAPHENOTHIAZINE; 10 (4 PIPERIDIN 1 YL BUT 2 YNYL) 2,7 DIAZAPHENOTHIAZINE; 10 (4 PYRROLIDIN 1 YL BUT 2 YNYL) 1,8 DIAZAPHENOTHIAZINE; 10 (4 PYRROLIDIN 1 YL BUT 2 YNYL) 2,7 DIAZAPHENOTHIAZINE; 10 DIALKYLAMINOBUTYNYL DERIVATIVE; 10 PROPARGYL 1,8 DIAZAPHENOTHIAZINE DERIVATIVE; 10 PROPARGYL 2,7 DIAZAPHENOTHIAZINE DERIVATIVE; 10 [4 (4 METHYLPIPERAZIN 1 YL)BUT 2 YNYL] 1,8 DIAZAPHENOTHIAZINE; 10 [4 (4 METHYLPIPERAZIN 1 YL)BUT 2 YNYL] 2,7 DIAZAPHENOTHIAZINE; 10 [4 (4 PHENYLPIPERAZIN 1 YL)BUT 2 YNYL] 1,8 DIAZAPHENOTHIAZINE; 10 [4 (4 PHENYLPIPERAZIN 1 YL)BUT 2 YNYL] 2,7 DIAZAPHENOTHIAZINE; 10 [4 (N ETHYL N METHYL)AMINO BUT 2 YNYL] 1,8 DIAZAPHENOTHIAZINE; 10 [4 (N ETHYL N METHYL)AMINO BUT 2 YNYL] 2,7 DIAZAPHENOTHIAZINE; 10 [4 (N,N DIETHYL)AMINO BUT 2 YNYL] 1,8 DIAZAPHENOTHIAZINE; 10 [4 (N,N DIETHYL)AMINO BUT 2 YNYL] 2,7 DIAZAPHENOTHIAZINE; 2,7 DIAZAPHENOTHIAZINE DERIVATIVE; ACETYLENE; AMINE; ANTINEOPLASTIC AGENT; CISPLATIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; FUNCTIONAL GROUP; PHENOTHIAZINE DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; PROTHIPENDYL; UNCLASSIFIED DRUG; PHENOTHIAZINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST TUMOR; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IC50; ISOMER; LIPOPHILICITY; MANNICH REACTION; MITOCHONDRION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TUMOR CELL LINE; WST-1 ASSAY; CHEMISTRY; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; PHENOTHIAZINES; PROTON MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT;

EID: 84989316822     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2015.1101092     Document Type: Article

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