Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives

Chinese Chemical Letters

Volumn 20, Issue 5, 2009, Pages 566-568

  Xiao, Feng ^a   Xue, Yadong ^a   Luo, Yu ^a   Zhang, Bo ^b   Lu, Wei ^a   Yang, Bo ^b  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Anticancer; Camptothecin; Synthesis

Indexed keywords

EID: 62849118422     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2008.12.019     Document Type: Article

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13. 3 (4.6 mmol) was added to toluene (15 mL) and refluxed for 10 h under nitrogen atmosphere. The mixture was cooled and evaporated to dryness and the residue was purified by column chromatography on silica gel to give 7-alkylcamptothecins.