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Volumn 77, Issue , 2014, Pages 47-55
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A convergent synthesis of alkyne-azide cycloaddition derivatives of 4-α,β-2-propyne podophyllotoxin depicting potent cytotoxic activity
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Author keywords
Apoptosis; Migration; Motility; Podophyllotoxin; Triazole
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Indexed keywords
4' DEMETHYL 4',4BETA (O DIPROPARGYL) EPIPODOPHYLLOTOXIN;
4' DEMETHYL 4',4BETA [O DIMETHYL (DIPHENYL DI 1,2,3 TRIAZOL 4YL)] EPIPODOPHYLLOTOXIN;
4ALPHA [4 O METHYL (PHENYL 1,2,3 TRIAZOL 4YL)] PODOPHYLLOTOXIN;
4ALPHA [O METHYL (META BROMO PHENYL 1,2,3 TRIAZOL 4YL)] PODOPHYLLOTOXIN;
4ALPHA [O METHYL (META CHLORO PARA FLUORO PHENYL 1,2,3 TRIAZOL 4YL)] PODOPHYLLOTOXIN;
4ALPHA [O METHYL (ORTHO FLUORO PHENYL 1,2,3 TRIAZOL 4YL)] PODOPHYLLOTOXIN;
4ALPHA [O METHYL (ORTHOCYANO PHENYL 1,2,3 TRIAZOL 4YL)] PODOPHYLLOTOXIN;
4ALPHA [O METHYL (ORTHOHYDROXY PHENYL 1,2,3 TRIAZOL 4YL)] PODOPHYLLOTOXIN;
4ALPHA [O METHYL (ORTHOIODO PHENYL 1,2,3 TRIAZOL 4YL)] PODOPHYLLOTOXIN;
4ALPHA [O METHYL (PARA BROMO PHENYL 1,2,3 TRIAZOL 4YL)] PODOPYLLOTOXIN;
4ALPHA [O METHYL (PARA CHLORO PHENYL 1,2,3 TRIAZOL 4YL)] PODOPHYLLOTOXIN;
4ALPHA [O METHYL (PARA TRIFLUOROMETHYL PHENYL 1,2,3 TRIAZOL 4YL)] PODOPHYLLOTOXIN;
4ALPHA [O METHYL (PARAMETHOXY PHENYL 1,2,3 TRIAZOL 4YL)] PODOPHYLLOTOXIN;
4BETA [4 O METHYL (PHENYL 1,2,3 TRIAZOL 4YL)] EPIPODOPHYLLOTOXIN;
4BETA [O METHYL (META BROMO PHENYL 1,2,3 TRIAZOL 4YL)] EPIPODOPHYLLOTOXIN;
4BETA [O METHYL (META CHLORO PARA FLUORO PHENYL 1,2,3 TRIAZOL 4YL)]PODOPHYLLOTOXIN;
4BETA [O METHYL (ORTHO FLUORO PHENYL 1,2,3 TRIAZOL 4YL)] EPIPODOPHYLLOTOXIN;
4BETA [O METHYL (ORTHOCYANO PHENYL 1,2,3 TRIAZOL 4YL)] EPIPODOPHYLLOTOXIN;
4BETA [O METHYL (ORTHOHYDROXY PHENYL 1,2,3 TRIAZOL 4YL)] EPIPODOPHYLLOTOXIN;
4BETA [O METHYL (ORTHOIODO PHENYL 1,2,3 TRIAZOL 4YL)] EPIPODOPHYLLOTOXIN;
4BETA [O METHYL (PARA BROMO PHENYL 1,2,3 TRIAZOL 4YL)] EPIPODOPHYLLOTOXIN;
4BETA [O METHYL (PARA CHLORO PHENYL 1,2,3 TRIAZOL 4YL)] EPIPODOPHYLLOTOXIN;
4BETA [O METHYL (PARA TRIFLUOROMETHYL PHENYL 1,2,3 TRIAZOL 4YL)] EPIPODOPHYLLOTOXIN;
4BETA [O METHYL (PARAMETHOXY PHENYL 1,2,3 TRIAZOL 4YL)] EPIPODOPHYLLOTOXIN;
ALKYNE DERIVATIVE;
ANTINEOPLASTIC AGENT;
AZIDE;
EPIPODOPHYLLOTOXIN;
PODOPHYLLOTOXIN;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
4-(O-METHYL(ORTHOCYANOPHENYL-1,2,3-TRIAZOL-4YL))PODOPHYLLOTOXIN;
ALKYNE;
TRIAZOLE DERIVATIVE;
ANTINEOPLASTIC ACTIVITY;
APOPTOSIS;
ARTICLE;
CANCER CELL CULTURE;
CARBON NUCLEAR MAGNETIC RESONANCE;
CONTROLLED STUDY;
CYCLOADDITION;
CYTOTOXICITY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
IC 50;
MTT ASSAY;
PROSTATE CANCER;
PROTON NUCLEAR MAGNETIC RESONANCE;
ANALOGS AND DERIVATIVES;
CELL PROLIFERATION;
CELL SURVIVAL;
CHEMICAL STRUCTURE;
CHEMISTRY;
CYCLIZATION;
DOSE RESPONSE;
DRUG EFFECTS;
DRUG SCREENING;
STRUCTURE ACTIVITY RELATION;
SYNTHESIS;
TOXICITY;
TUMOR CELL CULTURE;
ALKYNES;
ANTINEOPLASTIC AGENTS;
APOPTOSIS;
AZIDES;
CELL PROLIFERATION;
CELL SURVIVAL;
CYCLIZATION;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DRUG SCREENING ASSAYS, ANTITUMOR;
HUMANS;
MOLECULAR STRUCTURE;
PODOPHYLLOTOXIN;
STRUCTURE-ACTIVITY RELATIONSHIP;
TRIAZOLES;
TUMOR CELLS, CULTURED;
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EID: 84895835370
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2014.02.030 Document Type: Article |
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Times cited : (36)
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References (34)
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