Antioxidant activity of newly synthesized 2,7-diazaphenothiazines

Archiv der Pharmazie

Volumn 343, Issue 5, 2010, Pages 268-273

  Morak Młodawska, Beata ^a   Pluta, Krystian ^a   Matralis, Alexios N ^b   Kourounakis, Angeliki P ^b  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Lipid peroxidation; Lipophilicity; Microsomal membranes; Phenothiazine derivatives

Indexed keywords

10 (2' PIPERYDINYLETHYL) 2,7 DIAZAPHENOTHIAZINE; 10 (2' PYRIMIDINYL) 2,7 DIAZAPHENOTHIAZINE; 10 (2' PYRROLIDINYLETHYL) 2,7 DIAZAPHENOTHIAZINE; 10 (2',4'DINITROPHENYL) 2,7 DIAZAPHENOTHIAZINE; 10 (2'MORPHOLINYLETHYL) 2,7 DIAZAPHENOTHIAZINE; 10H 2,7 DIAZAPHENOTHIAZINE DERIVATIVE; ASCORBIC ACID; FERROUS ION; PHENOTHIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; LIPID PEROXIDATION; LIPOPHILICITY; LIVER MICROSOME; MICROSOME MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FERRIC COMPOUNDS; LIPID PEROXIDATION; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PHENOTHIAZINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77951582471     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200900253     Document Type: Article

References (28)

1. R. R. Gupta, M. Kumar in Phenothiazines and 1,4-Benzothiazines - Chemical and Biological Aspects, (Ed.: R. R. Gupta) Elsevier, Amsterdam, 1988, pp. 1-161.
2. L. Amaral, M. Vivieros, J. E. Kristiansen, Trop. Med. Int. Health 2001, 6, 1016-1022.
3. L. Amaral, J. E. Kristiansen, Int. J. Antimicrob. Agents 2001, 18, 411-417.
4. D. Ordway, M. Viveiros, C. Leandro, R. Bettencourt, et al., Antimicrob. Agents Chemother. 2003, 47, 917-922.
5. M. Viveiros, M. Martins, I. Couto, J. E. Kristiansen, et al., In Vivo 2005, 19, 733-736.
6. L. Amaral, M. Martins, M. Viveiros, J. Antimicrob. Chemother. 2007, 59, 1237-1246.
7. N. Motohashi, M. Kawase, T. Kurihara, A. Hever, et al., Anticancer Res. 1996, 16, 2525-2532.
8. N. Motohashi, T. Kurihara, H. Sakagami, D. Szabo, et al., Anticancer Res. 1999, 19, 1859-1864.
9. N. Motohashi, M. Kawase, S. Saito, H. Sakagami, Curr. Drug Targets 2000, 1, 237-245.
10. N. Motohashi, M. Kawase, K. Satoh, H. Sakagami, Curr. Drug Targets 2006, 7, 1055-1166
11. B. Morak-Młodawska, K. Pluta, Heterocycles 2007, 71, 1347-1361.
12. B. Morak-Młodawska, K. Pluta, Heterocycles 2009, 78, 1289-1298.
13. K. Pluta, M. Jelen, B. Morak-Młodawska, M. Zimecki, et al., Pharmacol. Rep. 2010, in press.
14. M. Zimecki, J. Artym, M. Kocieba, K. Pluta, et al., Cell. Mol. Biol. Lett. 2009, 14, 622-635.
15. K. Fukuzumi, N. Ikeda, M. Egawa, J. Am. Oil Chem. Soc. 1976, 53, 623.
16. A. Dalla Libera, G. Scutari, R. Boscolo, M. P. Rigobello, A. Bindoli, Free Radic. Res. 1998, 151-157.
17. C. M. Murphy, H. Ravner, N. L. Smith, Ind. Eng. Chem. 1950, 42, 2479-2489.
18. T. F. Slate, Biochem. J. 1968, 106, 155.
19. C. Breugnot, C. Mazibre, S. Salmon, S. M. Auclair, et al., Biochem. Pharmacol. 1990, 40, 1975-1980.
20. M. J. Yu, J. R. McCowan, K. J. Thrasher, P. T. Keith, et al., J. Med. Chem. 1992, 35, 716-724.
21. A. Bindoli, M. P. Rigobello, A. Favel, L. Galzigna, J. Neurochem. 1988, 50, 138-141.
22. C. Hansch, A. Leo, Substituent Constants for Correlation Analysis in Chemistry and Biology, J. Wiley & Sons, New York, 1991.
23. B. Morak, M. Nowak, K. Pluta, J. Liq. Chromatogr. Relat. Technol. 2007, 30, 1845.
24. B. Morak-Młodawska, K. Pluta, J. Liq. Chromatogr. Relat. Technol. 2008, 31, 611.
25. E. Stahl, Thin-layer chromatography, Springer-Verlag, Berlin, 1969, p. 508.
26. A. P. Kourounakis, C. Charitos, E. A. Rekka, P. N. Kourounakis, J. Med. Chem. 2008, 51, 5861-5865.
27. I. Jeding, P. J. Evans, D. Akamnu, D. Dexter, et al., Biochem. Pharmacol. 1995, 49, 359-365.
28. E. Rekka, J. Kolstee, H. Timmerman, A. Bast, Eur. J. Med. Chem. 1989, 24, 43-54.