2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes

European Journal of Medicinal Chemistry

Volumn 75, Issue , 2014, Pages 169-183

  Piras, Sandra ^a   Carta, Antonio ^a   Briguglio, Irene ^a   Corona, Paola ^a   Paglietti, Giuseppe ^a   Luciani, Rosaria ^b   Costi, Maria Paola ^b   Ferrari, Stefania ^b  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Anticancer agents; Dihydrofolate reductase; Enzyme inhibition; Thymidylate synthase; Trifluoromehylquinoxaline

Indexed keywords

ANTICANCER AGENTS; DIHYDROFOLATE REDUCTASE; ENZYME INHIBITION; THYMIDYLATE SYNTHASE; TRIFLUOROMEHYLQUINOXALINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FOLIC ACID; FOLIC ACID ANTAGONISTS; HALOGENATION; HUMANS; METHYLATION; MOLECULAR DOCKING SIMULATION; NEOPLASMS; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

EID: 84894139178     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.01.048     Document Type: Article

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