Harnessing the lysosome-dependent antitumor activity of phenothiazines in human small cell lung cancer

Cell Death and Disease

Volumn 5, Issue 3, 2014, Pages

  Zong, D ^a,b   Zielinska Chomej, K ^a   Juntti, T ^a   Mork B ^a   Lewensohn, R ^a   Haag P ^a   Viktorsson, K ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Lysosomal dysfunctions; Phenothiazines; Small cell lung cancer

Indexed keywords

CASPASE; CISPLATIN; ETOPOSIDE; FLUPHENAZINE; GEMCITABINE; PHENOTHIAZINE DERIVATIVE; PROMAZINE; PROTEIN P53; TRIFLUOPERAZINE; TRIFLUPROMAZINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DISRUPTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SENSITIVITY; HOMEOSTASIS; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; LYSOSOME; MUTATION; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; HUMANS; LUNG NEOPLASMS; LYSOSOMES; MUTATION; PHENOTHIAZINES; SMALL CELL LUNG CARCINOMA; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84897441779     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.56     Document Type: Article

References (34)

1. Shen WW. A history of antipsychotic drug development. Compr Psychiatry 1999; 40: 407-414.
2. Roth BL, Sheffler DJ, Kroeze WK. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nat Rev Drug Discov 2004; 3: 353-359.
3. Sudeshna G, Parimal K. Multiple non-psychiatric effects of phenothiazines: a review. Eur J Pharmacol 2010; 648: 6-14.
4. Motohashi N, Kawase M, Satoh K, Sakagami H. Cytotoxic potential of phenothiazines. Curr Drug Targets 2006; 7: 1055-1066.
5. Hait WN, Lee GL. Characteristics of the cytotoxic effects of the phenothiazine class of calmodulin antagonists. Biochem Pharmacol 1985; 34: 3973-3978.
6. Drori S, Eytan GD, Assaraf YG. Potentiation of anticancer-drug cytotoxicity by multidrugresistance chemosensitizers involves alterations in membrane fluidity leading to increased membrane permeability. Eur J Biochem 1995; 228: 1020-1029.
7. Lee MS, Johansen L, Zhang Y, Wilson A, Keegan M, Avery W et al. The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action. Cancer Res 2007; 67: 11359-11367.
8. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
9. Nordenberg J, Fenig E, Landau M, Weizman R, Weizman A. Effects of psychotropic drugs on cell proliferation and differentiation. Biochem Pharmacol 1999; 58: 1229-1236.
10. Sridhar KS, Krishan A, Samy TS, Sauerteig A, Wellham LL, McPhee G et al. Prochlorperazine as a doxorubicin-efflux blocker: phase I clinical and pharmacokinetics studies. Cancer Chemother Pharmacol 1993; 31: 423-430.
11. Rossi A, Martelli O, Di Maio M. Treatment of patients with small-cell lung cancer: from meta-analyses to clinical practice. Cancer Treat Rev 2012; 39: 498-506.
12. Daniel WA. Mechanisms of cellular distribution of psychotropic drugs. Significance for drug action and interactions. Prog Neuropsychopharmacol Biol Psychiatry 2003; 27: 65-73.
13. Kaufmann AM, Krise JP. Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications. J Pharm Sci 2007; 96: 729-746.
14. Hann CL, Rudin CM. Management of small-cell lung cancer: incremental changes but hope for the future. Oncology (Williston Park) 2008; 22: 1486-1492.
15. Hait WN, Morris S, Lazo JS, Figlin RJ, Durivage HJ, White K et al. Phase I trial of combined therapy with bleomycin and the calmodulin antagonist, trifluoperazine. Cancer Chemother Pharmacol 1989; 23: 358-362.
16. Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W et al. Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci USA 2007; 104: 19023-19028.
17. Poole B, Ohkuma S. Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages. J Cell Biol 1981; 90: 665-669.
18. Shacka JJ, Klocke BJ, Shibata M, Uchiyama Y, Datta G, Schmidt RE et al. Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons. Mol Pharmacol 2006; 69: 1125-1136.
19. Broker LE, Kruyt FA, Giaccone G. Cell death independent of caspases: a review. Clin Cancer Res 2005; 11: 3155-3162.
20. Erdal H, Berndtsson M, Castro J, Brunk U, Shoshan MC, Linder S. Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. Proc Natl Acad Sci USA 2005; 102: 192-197.
21. Galluzzi L, Vitale I, Vacchelli E, Kroemer G. Cell death signaling and anticancer therapy. Front Oncol 2011; 1: 5.
22. Joseph B, Lewensohn R, Zhivotovsky B. Role of apoptosis in the response of lung carcinomas to anti-cancer treatment. Ann N Y Acad Sci 2000; 926: 204-216.
23. Rodriguez-Nieto S, Zhivotovsky B. Role of alterations in the apoptotic machinery in sensitivity of cancer cells to treatment. Curr Pharm Des 2006; 12: 4411-4425.
24. Kaminskyy VO, Piskunova T, Zborovskaya IB, Tchevkina EM, Zhivotovsky B. Suppression of basal autophagy reduces lung cancer cell proliferation and enhances caspase-dependent and -independent apoptosis by stimulating ROS formation. Autophagy 2012; 8: 1032-1044.
25. Karpathiou G, Sivridis E, Koukourakis MI, Mikroulis D, Bouros D, Froudarakis ME et al. Light-chain 3A autophagic activity and prognostic significance in non-small cell lung carcinomas. Chest 2011; 140: 127-134.
26. Csatary LK. Chlorpromazines and cancer. Lancet 1972; 2: 338-339.
27. Hercbergs A. Thioridazine: a radiation enhancer in advanced cervical cancer? Lancet 1988; 2: 737.
28. Jones GR. Successful cancer therapy with promethazine: the rationale. Med Hypotheses 1996; 46: 25-29.
29. Castino R, Demoz M, Isidoro C. Destination 'lysosome': a target organelle for tumour cell killing? J Mol Recognit 2003; 16: 337-348.
30. Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S et al. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 2007; 21: 1621-1635.
31. Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 2007; 21: 1367-1381.
32. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25: 585-621.
33. Abate G, Mshana RN, Miorner H. Evaluation of a colorimetric assay based on 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) for rapid detection of rifampicin resistance in Mycobacterium tuberculosis. Int J Tuberc Lung Dis 1998; 2: 1011-1016.
34. Zong D, Haag P, Yakymovych I, Lewensohn R, Viktorsson K. Chemosensitization by phenothiazines in human lung cancer cells: impaired resolution of gammaH2AX and increased oxidative stress elicit apoptosis associated with lysosomal expansion and intense vacuolation. Cell Death Dis 2011; 2: e181.