Synthesis and anti-HIV-1 activity of new MKC-442 analogues with an alkynyl-substituted 6-benzyl group

Archiv der Pharmazie

Volumn 340, Issue 5, 2007, Pages 225-235

  Aly, Youssef L ^a,b   Pedersen, Erik B ^a   La Colla, Paolo ^c   Loddo, Roberta ^c  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b TANTA UNIVERSITY   (Egypt)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Human immunodeficiency virus (HIV 1); MKC 442; Non nucleoside reverse transcriptase inhibitors (NNRTI); Sonogashira coupling; Stacking

Indexed keywords

1 ALLYLOXYMETHYL 5 ETHYL 6 (3 ETHYNYLBENZYL) 1H PYRIMIDIN 2,4 DIONE; 1 ALLYLOXYMETHYL 5 ETHYL 6 [3 TRIMETHYLSILYLETHYNYL)BENZYL] 1 H PYRIMIDIN 2,4 DIONE; 1 ALLYLOXYMETHYL 5 METHYL 6 [3 (TRIMETHYLSILYLETHYNYL) BENZYL] 1H PYRIMIDIN 2,4 DIONE; 1 ALLYLOXYMETHYL 6 (3 BROMOBENZYL) 5 ETHYL 1H PYRIMIDIN 2,4 DIONE; 1 ALLYLOXYMETHYL 6 (3 BROMOBENZYL) 5 METHYL 1H PYRIMIDIN 2,4 DIONE; 1 ALLYLOXYMETHYL 6 (3 ETHYNYLBENZYL) 5 METHYL 1H PYRIMIDIN 2,4 DIONE; 1 ETHOXYMETHYL 5 ETHYL 6 (3 ETHYNYLBENZYL) 1H PYRIMIDIN 2,4 DIONE; 1 ETHOXYMETHYL 5 ETHYL 6 [3 (TRIMETHYLSILYLETHYNYL) BENZYL] 1H PYRIMIDIN 2,4 DIONE; 1 ETHOXYMETHYL 5 METHYL 6 [3 (TRIMETHYLSILYLETHYNYL) BENZYL] 1H PYRIMIDIN 2,4 DIONE; 1 ETHOXYMETHYL 6 (3 ETHYNYLBENZYL) 5 METHYL 1H PYRIMIDIN 2,4 DIONE; 5 ALKYL 6 (3 BROMOBENZYL) 1 ALLYLOXYMETHYL DERIVATIVE; 5 ALKYL 6 (3 BROMOBENZYL) 1 ETHOXYMETHYL DERIVATIVE; 6 (3 BROMOBENZYL) 1 ETHOXYMETHYL 5 ETHYL 1H PYRIMIDIN 2,4 DIONE; 6 (3 BROMOBENZYL) 1 ETHOXYMETHYL 5 METHYL 1H PYRIMIDIN 2,4 DIONE; 6 BENZYL 1 (ETHOXYMETHYL) 5 ISOPROPYLURACIL; ALKYNYL GROUP; BENZYL DERIVATIVE; BROMINE DERIVATIVE; EMIVIRINE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL REACTION; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; SONOGASHIRA REACTION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTI-HIV AGENTS; CELL LINE; CELL SURVIVAL; HIV-1; HUMANS; MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL; VIRUS REPLICATION;

EID: 34250790689     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200600163     Document Type: Article

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