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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 9, 2011, Pages 2746-2751

Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero) arylethynyl thiophene derivatives

(10) Romagnoli, Romeo a Baraldi, Pier Giovanni a Cruz Lopez, Olga a Tolomeo, Manlio b Cristina, Antonietta Di b Pipitone, Rosaria Maria b Grimaudo, Stefania b Balzarini, Jan c Brancale, Andrea d Hamel, Ernest e

a UNIVERSITY OF FERRARA (Italy)

b UNIVERSITY OF PALERMO (Italy)

c REGA INSTITUTE FOR MEDICAL RESEARCH (Belgium)

d CARDIFF UNIVERSITY (United Kingdom)

e NATIONAL CANCER INSTITUTE (United States)

Author keywords

Antiproliferative agents; Inhibition of tubulin polymerization; Inhibition of tumor cell growth; Thiophene

Indexed keywords

2 AMINO 3 (3',4',5' TRIMETHOXYBENZOYL) 5 (THIOPHEN 3' YL ETHYNYL)THIOPHENE; 2 AMINO 3 (3',4',5' TRIMETHOXYBENZOYL)THIOPHENE DERIVATIVE; 2 THIOPHENYL ACETYLENE DERIVATIVE; 3 THIOPHENYL ACETYLENE DERIVATIVE; ACETYLENE DERIVATIVE; ANTIMITOTIC AGENT; MELPHALAN; THIOPHENE; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONFERENCE PAPER; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN POLYMERIZATION; SONOGASHIRA REACTION;

ANIMALS; ANTIMITOTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; LEUKEMIA; MICE; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; UTERINE CERVICAL NEOPLASMS;

EID: 79955473280 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.11.083 Document Type: Conference Paper

Times cited : (29)

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