Acrolein increases macrophage atherogenicity in association with gut microbiota remodeling in atherosclerotic mice: protective role for the polyphenol-rich pomegranate juice

Archives of Toxicology

Volumn 91, Issue 4, 2017, Pages 1709-1725

  Rom, Oren ^a   Korach Rechtman, Hila ^a   Hayek, Tony ^a,b   Danin Poleg, Yael ^a   Bar, Haim ^c   Kashi, Yechezkel ^a   Aviram, Michael ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b Rambam Health Care Campus ^*  (Israel)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Acrolein; Gut microbiota; Lipid metabolism; Macrophage foam cells; Oxidative stress

Indexed keywords

ACROLEIN; APOLIPOPROTEIN E; CHOLESTEROL; DIACYLGLYCEROL ACYLTRANSFERASE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPID PEROXIDE; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL; POLYPHENOL;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BIOSYNTHESIS; BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; COMPARATIVE STUDY; CONTROLLED STUDY; HYPERLIPIDEMIA; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLORA; LIPID METABOLISM; LIPID PEROXIDATION; LIPID STORAGE; LIPOGENESIS; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERITONEUM MACROPHAGE; POMEGRANATE JUICE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RUMINOCOCCACEAE; THIN LAYER CHROMATOGRAPHY; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; KNOCKOUT MOUSE; LYTHRACEAE; MALE; PATHOLOGY;

ACROLEIN; ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CELL LINE; DISEASE MODELS, ANIMAL; GASTROINTESTINAL MICROBIOME; LIPID METABOLISM; MACROPHAGES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; POLYPHENOLS; PUNICACEAE;

EID: 84989183338     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-016-1859-8     Document Type: Article

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