Analysis of gut microbiota in coronary artery disease patients: A possible link between gut microbiota and coronary artery disease

Journal of Atherosclerosis and Thrombosis

Volumn 23, Issue 8, 2016, Pages 908-921

  Emoto, Takuo ^a   Yamashita, Tomoya ^a   Sasaki, Naoto ^a   Hirota, Yushi ^a   Hayashi, Tomohiro ^a   So, Anna ^a   Kasahara, Kazuyuki ^a   Yodoi, Keiko ^a   Matsumoto, Takuya ^a   Mizoguchi, Taiji ^a   Ogawa, Wataru ^a   Hirata, Ken Ichi ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bacteroidetes; Coronary artery disease; Gut microbiota; Lactobacillales

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; HEMOGLOBIN A1C; HISTAMINE H2 RECEPTOR ANTAGONIST; PROTON PUMP INHIBITOR; BACTERIAL DNA;

ADULT; AGED; ARTICLE; BACTEROIDETES; BODY MASS; CASE CONTROL STUDY; CLINICAL ARTICLE; CLOSTRIDIUM; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY RISK; DISEASE SEVERITY; FECES ANALYSIS; FEMALE; HUMAN; HYPERTENSION; INCIDENCE; INTESTINE FLORA; LACTOBACILLALES; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PREVOTELLA; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; COMPARATIVE STUDY; COMPLICATION; FECES; GENETICS; MICROBIOLOGY; PATHOGENICITY; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK FACTOR;

AGED; BACTEROIDETES; CASE-CONTROL STUDIES; CORONARY ARTERY DISEASE; DIABETES MELLITUS, TYPE 2; DNA, BACTERIAL; FECES; FEMALE; GASTROINTESTINAL MICROBIOME; HUMANS; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RISK FACTORS;

EID: 84980006417     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.32672     Document Type: Article

References (23)

1. Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, Bewtra M, Knights D, Walters WA, Knight R, Sinha R, Gilroy E, Gupta K, Baldassano R, Nessel L, Li H, Bushman FD and Lewis JD: Linkinglong-term dietary patterns with gut microbial enterotypes. Science, 2011; 334: 105-108
2. De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, Collini S, Pieraccini G and Lionetti P: Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences of the United States of America, 2010; 107: 14691-14696
3. Faith JJ, Guruge JL, Charbonneau M, Subramanian S, Seedorf H, Goodman AL, Clemente JC, Knight R, Heath AC, Leibel RL, Rosenbaum M and Gordon JI: The longterm stability of the human gut microbiota. Science, 2013; 341: 1237439
4. Ivanov, II and Honda K: Intestinal commensal microbes as immune modulators. Cell host & microbe, 2012; 12: 496-508
5. Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, Kim S, Fritz JV, Wilmes P, Ueha S, Matsushima K, Ohno H, Olle B, Sakaguchi S, Taniguchi T, Morita H, Hattori M and Honda K: Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature, 2013; 500: 232-236
6. Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov, II, Umesaki Y, Itoh K and Honda K: Induction of colonic regulatory T cells by indigenous Clostridium species. Science, 2011; 331: 337-341
7. Takeda M, Yamashita T, Sasaki N, Nakajima K, Kita T, Shinohara M, Ishida T and Hirata K: Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions. Arteriosclerosis, thrombosis, and vascular biology, 2010; 30: 2495-2503
8. Sasaki N, Yamashita T, Takeda M, Shinohara M, Nakajima K, Tawa H, Usui T and Hirata K: Oral anti-CD3 antibody treatment induces regulatory T cells and inhibits the development of atherosclerosis in mice. Circulation, 2009; 120: 1996-2005
9. Emoto T, Sasaki N, Yamashita T, Kasahara K, Yodoi K, Sasaki Y, Matsumoto T, Mizoguchi T and Hirata K: Regulatory/ effector T-cell ratio is reduced in coronary artery disease. Circulation journal: official journal of the Japanese Circulation Society, 2014; 78: 2935-2941
10. Yamashita T, Kasahara K, Emoto T, Matsumoto T, Mizoguchi T, Kitano N, Sasaki N and Hirata K: Intestinal Immunity and Gut Microbiota as Therapeutic Targets for Preventing Atherosclerotic Cardiovascular Diseases. Circulation journal: official journal of the Japanese Circulation Society, 2015; 79: 1882-1890
11. Ley RE, Turnbaugh PJ, Klein S and Gordon JI: Microbial ecology: human gut microbes associated with obesity. Nature, 2006; 444: 1022-1023
12. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER and Gordon JI: An obesity-associated gut microbiome with increased capacity for energy harvest. Nature, 2006; 444: 1027-1031
13. Vinje S, Stroes E, Nieuwdorp M and Hazen SL: The gut microbiome as novel cardio-metabolic target: the time has come! European heart journal, 2013;
14. Org E, Mehrabian M and Lusis AJ: Unraveling the environmental and genetic interactions in atherosclerosis: Central role of the gut microbiota. Atherosclerosis, 2015; 241: 387-399
15. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ and Hazen SL: Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature, 2011; 472: 57-63
16. Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ and Hazen SL: Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature medicine, 2013; 19: 576-585
17. Karlsson FH, Fak F, Nookaew I, Tremaroli V, Fagerberg B, Petranovic D, Backhed F and Nielsen J: Symptomatic atherosclerosis is associated with an altered gut metagenome. Nature communications, 2012; 3: 1245
18. Osborn AM, Moore ER and Timmis KN: An evaluation of terminal-restriction fragment length polymorphism (T-RFLP) analysis for the study of microbial community structure and dynamics. Environmental microbiology, 2000; 2: 39-50
19. Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M and Yokote K: Coronary artery disease. Executive summary of the Japan Atherosclerosis Society (JAS) guidelines for the diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan--2012 version. Journal of atherosclerosis and thrombosis, 2014; 21: 86-92
20. Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen HB, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal EG, Wang J, Guarner F, Pedersen O, de Vos WM, Brunak S, Dore J, Meta H.I.T.C, Antolin M, Artiguenave F, Blottiere HM, Almeida M, Brechot C, Cara C, Chervaux C, Cultrone A, Delorme C, Denariaz G, Dervyn R, Foerstner KU, Friss C, van de Guchte M, Guedon E, Haimet F, Huber W, van Hylckama-Vlieg J, Jamet A, Juste C, Kaci G, Knol J, Lakhdari O, Layec S, Le Roux K, Maguin E, Merieux A, Melo Minardi R, M'Rini C, Muller J, Oozeer R, Parkhill J, Renault P, Rescigno M, Sanchez N, Sunagawa S, Torrejon A, Turner K, Vandemeulebrouck G, Varela E, Winogradsky Y, Zeller G, Weissenbach J, Ehrlich SD and Bork P: Enterotypes of the human gut microbiome. Nature, 2011; 473: 174-180
21. Ding T and Schloss PD: Dynamics and associations of microbial community types across the human body. Nature, 2014; 509: 357-360
22. Karlsson FH, Tremaroli V, Nookaew I, Bergstrom G, Behre CJ, Fagerberg B, Nielsen J and Backhed F: Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature, 2013; 498: 99-103
23. Mazmanian SK, Round JL and Kasper DL: A microbial symbiosis factor prevents intestinal inflammatory disease. Nature, 2008; 453: 620-625