Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-β

Cardiovascular Research

Volumn 84, Issue 1, 2009, Pages 145-154

  Fuhrman, Bianca ^a   Gantman, Anna ^a   Khateeb, Jasmin ^a   Volkova, Nina ^a   Horke, Sven ^b   Kiyan, Julia ^c   Dumler, Inna ^c   Aviram, Michael ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Macrophages; NADPH oxidase; Paraoxonase 2; PDGF receptor ; SREBP2; Urokinase

Indexed keywords

4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; ARYLDIALKYLPHOSPHATASE 2; CHOLESTEROL; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UROKINASE; ARYLDIALKYLPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; PON2 PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE; SREBF2 PROTEIN, HUMAN; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; BIOSYNTHESIS; CATABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MACROPHAGE; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; UPREGULATION; CELL CULTURE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ARYLDIALKYLPHOSPHATASE; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HUMANS; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NADPH OXIDASE; REACTIVE OXYGEN SPECIES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TISSUE PLASMINOGEN ACTIVATOR; TRANSCRIPTION, GENETIC; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 70449730482     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp184     Document Type: Article

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